Orioles vs Yankees Prediction 9/21/25 MLB Picks Today

The New York Yankees and Baltimore Orioles meet Sunday in MLB action at Oriole Park at Camden Yards. Here’s a Orioles vs Yankees Prediction. This article will include a Orioles vs Yankees Pick.

New York Yankees Betting Preview

The New York Yankees are 87-68 on the year and play the White Sox and Orioles next. The New York Yankees are batting .250 on the season, have a .330 OBP, and a .454 slugging percentage. The New York Yankees pitching staff has a 4.00 ERA and a 1.26 WHIP. Aaron Judge leads the New York Yankees with 170 hits and 49 RBI, while Cody Bellinger and Paul Goldschmidt have combined for 285 hits and 141 RBI.

Cam Schlittler gets the ball for the New York Yankees, and he is 3-3 with a 3.41 ERA and 69 strikeouts this season. This will be Schlittler’s first career game against the Baltimore Orioles.

Baltimore Orioles Betting Preview

The Baltimore Orioles are 73-82 on the year and play the Rays and Yankees next. The Baltimore Orioles are batting .238 on the season, have a .306 OBP, and a .396 slugging percentage. The Baltimore Orioles pitching staff has a 4.60 ERA and a 1.37 WHIP. Gunnar Henderson leads the Baltimore Orioles with 152 hits and 65 RBI while Jackson Holliday and Ryan Mountcastle have combined for 221 hits and 88 RBI.

Kyle Bradish gets the ball for the Baltimore Orioles, and he is 1-1 with a 2.45 ERA and 30 strikeouts this season. Bradish is 1-1 with a 3.24 ERA and 24 strikeouts in his career against the New York Yankees.

New York Yankees @ Baltimore Orioles Betting Trends: September 21, 2025

• Probable Starting Pitcher: Kyle Bradish      Record this season: 1-1      ERA: 2.45
• Home Record: 0-1
• Last 5 against Yankees: 1-1

Why the Baltimore Orioles will win

• The Yankees have lost eight of their last 10 games as favorites against the Orioles following a win.
• The Orioles have won four of their last five games as underdogs against the Yankees following a loss.
• The Orioles have covered the run line in six of their last seven games as home underdogs against AL East opponents following a loss.
• The Yankees have failed to cover the run line in 15 of their last 18 games as favorites against the Orioles following a road win.
• The Orioles have led after 5 innings in three of their last four day games at Oriole Park at Camden Yards against AL East opponents.

• Probable Starting Pitcher: Cam Schlittler      Record this season: 3-3      ERA: 3.41
• Road Record: 0-1
• Last 5 against Orioles: –

Why the New York Yankees will win

• The Orioles have lost nine of their last 10 games against AL East opponents.
• The Yankees have won seven of their last eight games against AL East opponents that held a losing record.
• The Yankees have covered the run line in seven of their last eight games against AL East opponents that held a losing record.
• The Orioles have failed to cover the run line in three of their last four home games.
• The Yankees have led after 3 innings in each of their last five day games.
• The Yankees have led after 5 innings in each of their last five day games.
• The Yankees have won the first inning in five of their last six games as favorites against AL East opponents.

Total Runs Facts

• Each of the Orioles’ last 14 home games have gone UNDER the total runs line.
• Each of the Yankees’ last eight games as favorites against AL East opponents have gone UNDER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in seven of the last eight games between the Yankees and Orioles.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in seven of the Yankees’ last eight road games against AL East opponents.

Baltimore Orioles Player Prop Facts

• Kyle Bradish has recorded six or more strikeouts in each of his last five appearances against AL opponents.
• Gunnar Henderson has recorded at least one hit in each of the Orioles’ last nine home games against the Yankees.
• Tyler O’Neill has hit a home run in three of his last five home appearances after playing the previous day.
• Dylan Carlson has recorded a Double in each of his last three home appearances against AL East opponents.

New York Yankees Player Prop Facts

• Aaron Judge has hit at least one home run in four of his last five appearances in day games against teams that held a losing record.
• Aaron Judge has recorded at least one hit in each of the Yankees’ last 13 Sunday games against AL opponents that held a losing record.
• Amed Rosario has recorded a Double in four of his last five appearances against AL East opponents that held a losing record.
• Aaron Judge ranks 1st amongst qualified players for Batting Average (.329) this season.

Matchup/League Facts

• The Orioles rank 27th in the league for strikeouts against this season (1386).
• The Orioles rank 27th in the league for home runs allowed this season (205).
• The Yankees rank 1st in the league for runs scored this season (809).
• The Yankees rank 1st in the league for home runs this season (261).

Orioles vs Yankees Prediction

The Yankees need to take advantage of games like this if they’re trying to win the AL East. The Orioles aren’t good. Bradish has been solid this season, but he’s pitched just 22 innings so it’s not enough of a sample size to trust. In 27.1 road innings, Schlittler has a 2.96 ERA and .192 allowed batting average. I like taking teams that are still playing for something entering the final week. The Yankees have a favorable schedule to make a division push, and it starts here. Give me the Yanks.