Padres vs Angels Prediction 5/14/25 MLB Picks Today

In this article, we will formulate a Padres vs Angels prediction for this MLB game on Wednesday, May 14, at PETCO Park in San Diego, California. Let’s take a look at the prediction for this MLB matchup.

Los Angeles Angels Betting Preview

The Los Angeles Angels (17-24, 8-14 Away) were on a negative run of seven series losses before defeating the Toronto Blue Jays. Still, the Angels returned to losing ways against the Baltimore Orioles but opened the current series in San Diego with a surprising 9-5 win. The hosts did respond with a 6-4 win in Game 2, though. Mathew Lugo led the Angels with two RBI, while Jose Soriano pitched for 7.0 innings in a no-decision, allowing two runs on four hits with five strikeouts and three walks. Kenley Jansen took the loss.

This season, the Angels average 3.83 runs per game (24th in the MLB) on a .216/.276/.389 triple-slash. When it comes to pitching, the Angels’ staff has a 5.13 ERA (26th) and 1.49 WHIP (28th). Taylor Ward leads the Angels with a .185 batting average, nine home runs, and 21 RBI this season.

Kyle Hendricks will take the mound for the Angels on Wednesday. The 35-year-old right-hander has a 1-4 record in seven starts this year with a 5.30 ERA and 1.26 WHIP in 35.2 innings.

San Diego Padres Betting Preview

The San Diego Padres (26-15, 15-5 Home) won three of the last four series and spent the previous three series on teh road. Following a win over the Colorado Rockies, the Padres opened the current series against the Angels with a 9-5 defeat, but responded with a 6-4 victory on Tuesday. San Diego was 4-2 down until the 8th inning. Fernando Tatis Jr. led the offense with two RBI, while Dylan Cease pitched for 6.2 innings in a no-decision, allowing two runs on five hits with ten strikeouts and one walk. Jason Adam was credited with the win.

This year, the Padres average 4.66 runs per game (12th in the MLB) on a .265/.333/.401 triple-slash. When it comes to pitching, the Padres’ staff has a 3.38 ERA (6th) and 1.18 WHIP (6th). Fernando Tatis Jr. leads the Rockies with a .316 batting average, 11 home runs, and 26 RBI this season.

The projected starting pitcher for the Padres is Randy Vasquez, who is 2-3 in eight starts this season, with a 3.76 ERA and 1.59 WHIP in 38.1 innings.

Why the Padres will beat the Angels

• The Padres have won each of their last 10 games as favorites following a home win.
• The Angels have lost each of their last eight Wednesday road games.
• The Padres have covered the run line in each of their last 11 games at Petco Park following a win.
• The Angels have failed to cover the run line in 10 of their last 11 road games.
• The Padres have led after 3 innings in three of their last four games at Petco Park.
• The Padres have led after 5 innings in each of their last five night games.

Total Runs Facts

• Each of the Padres’ last five games have gone OVER the total runs line.
• Each of the Angels’ last four road games have gone OVER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in seven of the Padres’ last eight night games against American League opponents.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in five of the Angels’ last six games as underdogs.

Matchup/League Facts

• The Padres rank 3rd in the league for opponent batting average this season (.219).
• The Padres rank 3rd in the league for hits allowed this season (292).
• The Angels rank 29th in the league for batting average this season (.216).
• The Angels rank T29th in the league for strikeouts against this season (404).

Padres vs Angels Prediction

The teams have traded wins in the past couple of years, each recording five in the previous ten H2H encounters. The Angels win four of the last five, but I am going with the Padres in this one as I am giving a slight advantage to Vasquez over Hendricks. Vasquez allowed three runs in his last two starts and surrendered more than two runs only twice this year. Hendricks, on the other hand, allowed 3+ runs in four of his previous four starts. The Padres should do enough to score 3+ off him early on and later add some more runs against one of the worst bullpens in the MLB.