Padres vs Guardians Prediction 3/31/25 MLB Picks Today

In this article, we will formulate a Padres vs Guardians prediction for this MLB game on Monday, March 31st, at Petco Park in San Diego, California. Let’s take a look at the prediction for this MLB matchup. 

San Diego Padres Betting Preview

The San Diego Padres are 4-0 this year after they swept the Braves in four games to start the season. San Diego won all four games by scores of 5-0, 1-0, 4-3, and 7-4. In game four, San Diego scored one run in the first, one in the third, one in the seventh, and two in the eighth for the shutout win. The Padres recorded nine hits in the game and held Atlanta to just one, while Tatis Jr. went 2-3 with one RBI and two walks in the win. San Diego started Pivetta, who went 7.0 innings and allowed one hit and zero earned runs, while Adam and Estrada combined for two shutout innings out of the bullpen. 

The San Diego pitching staff has a 1.75 ERA with a 0.94 WHIP and a .148 opponent batting average, while the offense has scored 17 runs with a .270 batting average and a .336 on-base percentage this year. Jackson Merrill has led San Diego with a .462 batting average and five RBIs, while Tatis Jr. and Cronenworth have added one home run each. The projected starting pitcher for San Diego is Kyle Hart, who went 0-1 with a 15.55 ERA and a 3.09 WHIP over 11.0 innings pitched for Boston back in 2020. 

Cleveland Guardians Betting Preview

The Cleveland Guardians are 2-1 this season after they won two out of three against the Royals over the weekend. Cleveland won games one and three by scores of 7-4 and 6-2, but it did lose game two by a score of 4-3. In game three, the Guardians scored the first six runs in the game and were able to coast to the win in the final few innings. Cleveland recorded 11 hits and committed one error in the game, while Kwan went 3-5 with one RBI, and Manzardo went 2-5 with one home run and two RBIs. The Guardians started Bibee, who went 5.2 innings and allowed just two hits in the win. 

The Cleveland pitching staff has a 2.67 ERA with a 1.07 WHIP and a .218 opponent batting average, while their offense has scored 16 runs with a .263 batting average and a .336 on-base percentage this year. Kyle Manzardo has led Cleveland with two home runs and six RBIs, while Steven Kwan has added one home run and three RBIs so far this year. The projected starting pitcher for Cleveland is Luis Ortiz, who went 7-6 with a 3.32 ERA and a 1.11 WHIP over 135.2 innings pitched last season for the Pirates. 

Why the Padres will beat the Guardians

• The Guardians have lost each of their last eight night games against NL West opponents following a win.
• The Padres have won 11 of their last 12 games at Petco Park.
• The Guardians have failed to cover the run line in each of their last nine night games against NL West opponents following a win.
• The Padres have covered the run line in four of their last five games against American League opponents after playing the previous day.
• The Guardians have trailed after 5 innings in four of their last five games against NL West opponents that held a winning record.
• The Padres have won the first inning in three of their last four games against opponents that held a winning record at Petco Park.
• The Padres have led after 3 innings in five of their last six home night games.

Total Runs Facts

• Six of the Guardians’ last seven games as underdogs against National League opponents have gone UNDER the total runs line.
• Six of the Padres’ last seven home games against American League opponents have gone UNDER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Padres’ last six games as favorites.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in 14 of the Guardians’ last 16 road games against NL West opponents.

San Diego Padres Player Prop Facts

• Jackson Merrill has recorded a Double in each of the Padres’ last four night games against AL Central opponents that held a winning record.
• Jake Cronenworth has scored at least one run in each of the Padres’ last four night games against AL Central opponents that held a winning record.
• Manny Machado has recorded at least one RBI in each of the Padres’ last five home games against AL opponents that held a winning record.
• Xander Bogaerts has recorded at least one hit in each of his last 22 home appearances against the Guardians.
• Martin Maldonado has hit a home run in each of his last three appearances against AL opponents that held a winning record.
• Jose Iglesias has recorded at least one Single in 17 of his last 19 appearances against opponents that held a winning record.
• Fernando Tatis Jr. ranks T1st in the league in Hits (7) this season.

Cleveland Guardians Player Prop Facts

• Lane Thomas has hit a home run in each of the Guardians’ last two night games against NL opponents that held a winning record.
• Jose Ramirez has recorded a Double in three of the Guardians’ last four games against NL opponents.
• Steven Kwan has recorded an RBI in each of the Guardians’ last four games.
• Steven Kwan has scored at least one run in each of his last five road appearances after playing the previous day.
• Steven Kwan has recorded at least one Single in each of his last eight appearances after playing the previous day.
• Steven Kwan has recorded at least one hit in each of his last 10 road appearances.
• Kyle Manzardo ranks 3rd amongst qualified players for Slugging Percentage (1.273) this season.

Padres vs Guardians Prediction 

San Diego comes into this matchup looking to stay undefeated in the season, and they haven’t allowed a single run over their last two games. The Padres will turn to Kyle Hart, who hasn’t pitched in the MLB since 2020, when he was pretty bad in limited action. Cleveland took two out of three against Kansas City to start the season, and they scored 13 runs in those two wins. The Guardians will give the ball to Luis Ortiz, who was a very solid option for Pittsburgh last year. I do think Cleveland has a great chance in this game with this pitching matchup, but I am going to ride the red-hot Padres, who did not have to travel on Sunday.