Padres vs Guardians Prediction 4/2/25 MLB Picks Today

The Cleveland Guardians and San Diego Padres meet on Wednesday in MLB action at Petco Park. Here’s a Padres vs Guardians Prediction. This article will include a Padres vs Guardians Pick.

Cleveland Guardians Betting Preview

The Cleveland Guardians are 2-3 on the year and play the Angels, White Sox, and Royals next. The Cleveland Guardians are batting .224 on the season and have a .303 OBP and a .410 slugging percentage. The Cleveland Guardians’ pitching staff has a 4.19 ERA and a 1.47 WHIP. Steven Kwan leads the Cleveland Guardians with 7 hits and 3 RBI, while Gabriel Arias and Kyle Manzardo have combined for 10 hits and 8 RBI.

Ben Lively gets the ball for the Cleveland Guardians, and he is 0-0 with a 5.40 ERA and 3 strikeouts this season. This will be Lively’s second career game against the San Diego Padres.

San Diego Padres Betting Preview

The San Diego Padres are 6-0 on the year and play the Cubs, Athletics, and Rockies next. The San Diego Padres are batting .299 in the season, have a .376 OBP, and a .435 slugging percentage. The San Diego Padres’ pitching staff has a 1.50 ERA and a 0.89 WHIP. Fernando Tatis Jr. leads the San Diego Padres with 9 hits and 5 RBI, while Manny Machado and Jackson Merrill have combined for 16 hits and 8 RBI.

Dylan Cease gets the ball for the San Diego Padres, and he is 0-0 with a 6.23 ERA and 7 strikeouts this season. Cease is 6-5 with a 3.57 ERA and 67 strikeouts in his career against the Cleveland Guardians.

Why the San Diego Padres will win

• The Padres have won each of their last nine games against teams that held a losing record.
• The Guardians have lost each of their last seven day games against NL West opponents that held a winning record.
• The Guardians have failed to cover the run line in each of their last seven day games against NL West opponents.
• The Padres have covered the run line in each of their last five games against American League opponents after playing the previous day.
• The Guardians have trailed after 3 innings in four of their last five day games against NL West opponents.
• The Guardians have trailed after 5 innings in each of their last five day games against NL West opponents.

Why the Cleveland Guardians will win

• The Padres have lost each of their last four Wednesday day games as favorites against AL Central opponents.
• The Guardians have won four of their last five day games after playing the previous day.
• The Padres have failed to cover the run line in 12 of their last 13 day games against AL Central opponents that held a losing record.
• The Guardians have covered the run line in 15 of their last 18 games against National League opponents following a road loss.
• The Guardians have won the first inning in three of their last four games against National League opponents.
• The Guardians have led after 5 innings in three of their last four day games.

Padres vs Guardians Prediction

Lively has been a hit-or-miss pitcher his entire career, and he was shaky in his season debut against the Royals. You just never know what you’re going to get from Lively from start to start. Cease was awful in his season debut, but he’s a veteran who consistently misses bats at an above-average rate, and you expect him to kind of right the ship.

The bottom line is that the Padres are rolling at the plate and on the mound, setting the tone early as a potential top-five team in baseball. Until the tickets stop cashing, I’m not trying to step in front of the Padres. Give me the Padres, and I’ll lay the RL to shave down the juice.