Padres vs Nationals Prediction 6/25/25 MLB Picks Today

The Washington Nationals and the San Diego Padres meet Wednesday in MLB action from Petco Park. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Padres vs Nationals Prediction.

Starting Pitching Matchup

The Washington Nationals will send out Mackenzie Gore for the start here, and Gore is 3-7 with a 3.19 ERA and 123 strikeouts this season. In his career, Gore is 1-1 with a 5.52 ERA and 15 strikeouts. Nick Pivetta will get the start for the Padres here and is 7-2 with a 3.64 ERA and 91 strikeouts this season. In his last five starts against the Nationals, Pivetta is 0-4 with an 8.74 ERA and 18 strikeouts.

Washington Nationals Recap

The Washington Nationals come into this game looking to rebound from a 4-3 loss at the hands of the Padres to slip to 33-47 on the year. After this series, the Nationals will head on the road for a series against the Los Angeles Angels.

Nationals Alternate Wins & Losses In 7 Straight

Keibert Ruiz has 61 hits with 12 doubles and a pair of home runs with 24 RBIs, while James Wood has 85 hits with 19 doubles and a team-high 22 home runs, along with 63 RBIs and 9 stolen bases while also putting up 95 strikeouts. Nathaniel Lowe has 69 hits with 12 doubles and 52 RBIs, along with 13 home runs and 89 strikeouts. CJ Abrams has 11 home runs and 26 RBIs, along with 17 doubles and 16 stolen bases, while Luis Garcia Jr. has 19 doubles and 7 stolen bases of his own this season. Dylan Crews has also logged 11 stolen bases this season.

Why the Washington Nationals will win

• The Nationals have won each of their last four games as underdogs against NL West opponents following a loss.
• The Padres have lost each of their last four games as favorites against National League opponents following a win.
• The road team has covered the run line in 12 of the Nationals’ last 13 games.
• The Padres have failed to cover the run line in each of their last six games as favorites following a win.

Washington Nationals Player Prop Facts

• Josh Bell has hit a home run in five of his last nine road appearances after playing the previous day.
• MacKenzie Gore has recorded six or more strikeouts in nine of his last 10 appearances against NL opponents that held a winning record.
• Amed Rosario has recorded a Double in three of his last four appearances in day games against teams that held a winning record.
• Amed Rosario has recorded at least one hit in each of his last 13 appearances with the Nationals as underdogs against NL opponents.
• MacKenzie Gore ranks 3rd in the league for total Strikeouts (123) this season.

San Diego Padres Recap

The San Diego Padres come into this game looking to build on their win over the Nationals from Tuesday to sit at 43-36 on the year. After this series, the Padres will head on the road for a series against the Cincinnati Reds.

Padres Win 4 Of Their Last 6

Manny Machado has 91 hits, including a team-high 20 doubles, 13 home runs, 47 RBIs, and 8 stolen bases, while Fernando Tatis Jr. has 78 hits with a team-high 15 home runs and 37 RBIs, along with 15 stolen bases of his own this season. Luis Arraez has added 84 hits with 16 doubles, 4 triples, 3 home runs, and 29 RBIs, while Jackson Merrill’s added 56 hits with 5 home runs and 26 RBIs as well. Xander Bogaerts also has 15 doubles and 13 stolen bases this season. Gavin Sheets also has 12 doubles, 12 home runs, and 46 RBIs this season.

Why the San Diego Padres will win

• The Nationals have lost eight of their last nine day games after playing the previous day.
• The Padres have won seven of their last eight games against the Nationals.
• The Nationals have failed to cover the run line in each of their last four day games against National League opponents.
• The Padres have covered the run line in five of their last six day games against National League opponents.

San Diego Padres Player Prop Facts

• Gavin Sheets has hit a home run in each of the Padres’ last two day games against NL East opponents that held a losing record.
• Jackson Merrill has recorded at least one Double in four of the Padres’ last five day games against opponents that held a losing record.
• Nick Pivetta has recorded a win in five of his last six home appearances against NL opponents.
• Gavin Sheets has recorded at least one hit in each of the Padres’ last 12 games against NL opponents.
• Nick Pivetta has recorded six or more strikeouts in 10 of his last 12 home appearances against opponents that held a losing record.
• Manny Machado is one of only three players to hit over .300 and have 45+ RBIs this season.

Total Runs Facts

• Eleven of the Nationals’ last 12 day games against National League opponents have gone UNDER the total runs line.
• Five of the last six games between the Nationals and Padres at Petco Park have gone OVER the total runs line.

Padres vs Nationals Prediction

I’m on the Nationals here. I get the case to be made for the Padres here, but the Padres have been shaky offensively against left-handed pitching and are not a team I’m trying to back in a spot like this. Gore has been solid as of late, and I think he can hold down the Padres while the Nats’ offense can get to Nick Pivetta for enough to get the win here. Give me the Nationals and the plus money.