Pirates vs Brewers Prediction 9/6/25 MLB Picks Today

In this article we will formulate a Pirates vs Brewers prediction for this MLB game on Saturday, September 6th at PNC Park in Pittsburgh, Pennsylvania. Let’s take a look at the prediction for this MLB matchup. 

Pittsburgh Pirates Betting Preview

The Pittsburgh Pirates are 64-78 this year after they lost game one by a score of 5-2 on Friday night. Pittsburgh led 2-1 in the third inning, but they failed to score over the last six innings in the defeat. The Pirates recorded six hits and they committed three errors in the game, while they were led by Pham and Cruz, who both had one RBI in the loss. Pittsburgh started Oviedo, who allowed one hit and zero earned runs over 5.0 innings, while Mlodzinski allowed two earned runs and picked up the loss. 

Prior to this series, the Pirates won all three against the Dodgers and two out of three against the Red Sox. Pittsburgh has won five of their last seven games and they are currently last in the NL Central standings. The Pittsburgh pitching staff has a 3.87 ERA with a 1.22 WHIP and a .237 opponent batting average, while their offense has scored 519 runs with a .234 batting average and a .307 on base percentage this season. Oneil Cruz has led Pittsburgh with 19 home runs and 55 RBIs, while Bryan Reynolds has added 15 home runs and 70 RBIs this year. The projected starting pitcher for Pittsburgh is Mitch Keller, who is 6-13 with a 4.21 ERA and a 1.28 WHIP over 156.0 innings pitched this year. 

Milwaukee Brewers Betting Preview

The Milwaukee Brewers are 87-55 this season after they won game one by a score of 5-2 on Friday. Milwaukee had trouble at the plate to start the game, but they scored four runs in the last four innings to seal the victory. The Brewers recorded 10 hits in the game and they were led by Bauers, who went 2-5 with two RBIs in the win. Milwaukee started Priester, who allowed six hits and two earned runs over 7.0 innings for the win, while Uribe picked up the save. 

Prior to this series, the Brewers lost two out of three against the Phillies, but did win two out of three against the Blue Jays before that. Milwaukee has lost three of their last five games, but they continue to lead the NL Central. The Milwaukee pitching staff has a 3.62 ERA with a 1.24 WHIP and a .232 opponent batting average, while the offense has scored 722 runs with a .259 batting average and a .332 on base percentage this season. Christian Yelich has led Milwaukee with 27 home runs and 92 RBIs, while William Contreras has added 17 home runs and 69 RBIs this year. The projected starting pitcher for Milwaukee is Brandon Woodruff, who is 5-2 with a 3.69 ERA and a 1.02 WHIP over 53.2 innings pitched this season. 

Why the Pirates will beat the Brewers

• The underdogs have won eight of the Brewers’ last nine games.
• The Brewers have lost seven of their last eight games as favorites against the Pirates following a road win.
• The Pirates have covered the run line in each of their last seven games following a loss.
• The Brewers have failed to cover the run line in each of their last seven games as favorites following a win.
• The Pirates have led after 3 innings in each of their last six home night games.
• The Pirates have led after 5 innings in seven of their last eight home games.

Total Runs Facts

• Five of the Pirates’ last six home games after playing the previous day have gone UNDER the total runs line.
• Nine of the Brewers’ last 12 games as favorites against NL Central opponents have gone OVER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Brewers’ last six Saturday night games.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in five of the Pirates’ last six games as home underdogs.

Pittsburgh Pirates Player Prop Facts

• Oneil Cruz has hit at least one home run in two of his last three home appearances against the Brewers after playing the previous day.
• Mitch Keller has recorded five or more strikeouts in each of his last eight appearances against the Brewers.
• Bryan Reynolds has recorded at least one hit in 10 of his last 11 appearances against the Brewers.
• Jack Suwinski has recorded a Double in three of his last four appearances with the Pirates as home underdogs against the Brewers.

Milwaukee Brewers Player Prop Facts

• Christian Yelich has hit a home run in three of his last four appearances in night games against NL Central teams that held a losing record.
• Brandon Woodruff has recorded eight or more strikeouts in each of his last five Saturday appearances against NL teams that held a losing record.
• Christian Yelich has recorded at least one hit in each of his last 18 appearances against NL Central opponents that held a losing record.
• Brandon Woodruff has recorded a win in each of his last five road appearances against opponents that held a losing record.
• Danny Jansen has recorded a Double in four of his last five appearances with his team as a road favorite against NL Central opponents.

Pirates vs Brewers Prediction 

Milwaukee was able to get the win on Friday to start this series, but Pittsburgh gave them plenty of help with some bad fielding. The Pirates are 42-31 at home this season, while the Brewers are 41-29 on the road. Pittsburgh is playing very well right now and they are starting Keller, who has allowed at least three earned runs in three of his last four starts. Milwaukee is going with Woodruff, who has allowed 10 earned runs and 15 hits in his last 10.0 innings. I don’t love how Woodruff has looked in his last two starts and with Pittsburgh playing well, I like the Pirates at home.