Pirates vs Cardinals Prediction 9/22/26 MLB Picks Today

The St. Louis Cardinals and Pittsburgh Pirates meet Tuesday in MLB action at PNC Park. Here’s a Pirates vs. Cardinals Prediction. This article will include a Pirates vs. Cardinals Pick.

St. Louis Cardinals Betting Preview

The St. Louis Cardinals are 76-80 on the year and play the Brewers next. The St. Louis Cardinals are batting .242 on the season, with a .315 OBP and a .382 slugging percentage. The St. Louis Cardinals’ pitching staff has a 4.29 ERA and a 1.36 WHIP. Alec Burleson leads the St. Louis Cardinals with 165 hits and 111 RBI, while Jordan Walker and Ivan Herrera have combined for 305 hits and 168 RBI.

Andre Pallante gets the ball for the St. Louis Cardinals, and he is 12-7 with a 3.70 ERA and 104 strikeouts this season. Pallante is 2-2 with a 3.12 ERA and 34 strikeouts in his career against the Pittsburgh Pirates.

Pittsburgh Pirates Betting Preview

The Pittsburgh Pirates are 79-77 this year and play the Tigers next. The Pittsburgh Pirates are batting .254 on the season, with a .332 OBP and a .406 slugging percentage. The Pittsburgh Pirates’ pitching staff has a 4.19 ERA and a 1.30 WHIP. Nick Gonzales leads the Pittsburgh Pirates with 162 hits and 60 RBI, while Bryan Reynolds and Brandon Lowe have combined for 300 hits and 164 RBI.

Jared Jones gets the ball for the Pittsburgh Pirates, and he is 4-6 with a 4.17 ERA and 109 strikeouts this season. Jones is 0-1 with a 3.72 ERA and 11 strikeouts in his career against the St. Louis Cardinals.

Why the Pittsburgh Pirates will win

• The Pirates have won each of their last four games.
• The Cardinals have lost six of their last seven road games following a win.
• The Cardinals have failed to cover the run line in seven of their last eight games against NL opponents.
• The Pirates have covered the run line in four of their last five games against NL Central opponents.
• The Cardinals have lost the first inning in each of their last four road games.
• The Cardinals have trailed after 3 innings in five of their last six night games against NL opponents.
• The Cardinals have trailed after 5 innings in six of their last seven night games against NL opponents.

Why the St. Louis Cardinals will win

• The underdogs have won each of the Cardinals’ last five games at PNC Park.
• The Pirates have lost each of their last three games as favorites against NL opponents following a home win.
• The underdogs have covered the run line in 15 of the Cardinals’ last 16 games at PNC Park.
• The Pirates have failed to cover the run line in 12 of their last 13 night games at PNC Park following a home win.
• The Cardinals have led after 3 innings in four of their last five night games against the Pirates.
• The Cardinals have led after 5 innings in each of their last seven road games against NL Central opponents.

Total Runs Facts

• Nine of the Cardinals’ last 10 games as road underdogs have gone OVER the total runs line.
• Six of the Pirates’ last seven night games against NL Central opponents have gone UNDER the total runs line.
• There has been no run scored during the first inning in each of the Pirates’ last eight home games against NL Central opponents.
• There has been at least one run scored in the first inning in seven of the Cardinals’ last eight road games.

Pittsburgh Pirates Player Prop Facts

• Brandon Lowe has hit a home run in each of the Pirates’ last four night games.
• Jared Jones has recorded six or more strikeouts in each of his last five appearances in night games.
• Brandon Lowe has recorded at least one hit in each of the Pirates’ last eight games.
• Nick Gonzales ranks 6th amongst qualified players for Batting Average (.302) this season.

St. Louis Cardinals Player Prop Facts

• Nathan Church has recorded at least one hit in each of the Cardinals’ last nine road games.
• Andre Pallante has recorded four or more strikeouts in three of his last four road appearances.
• Andre Pallante has recorded a win in seven of his last eight appearances with the Cardinals as road underdogs.
• Nolan Gorman has hit a home run in three of his last four appearances against the Pirates after not playing the previous day.
• Alec Burleson ranks T8th in the league in Hits (165) this season.

Matchup/League Facts

• The Pirates rank T1st in the league for home runs allowed this season (150).
• The Pirates rank 2nd in the league for hits this season (1363).
• The Cardinals rank 27th in the league for slugging percentage this season (.382).
• The Cardinals rank 4th in the league for home runs allowed this season (155).

Pirates vs Cardinals Prediction

Jones has been good this month, but he has a 4.17 ERA on the season, and at home he has a 4.68 ERA. You can get to Jones. Pallante has been sharper with a 3.70 ERA on the season, and on the road he has a 2.76 ERA and a .214 allowed batting average through 65.1 innings. Two teams with nothing to play for, I’ll grab the plus money with the pitcher in better form. Give me the Cards.