Red Sox vs Astros Prediction 5/1/26 MLB Picks Today
Houston Astros (12-20) vs. Boston Red Sox (12-19)
May 1, 2026 7:10 pm EDT
The Line: Boston Red Sox -115 / Houston Astros -105; Over/Under: 9.5
(Get latest betting odds)
The Houston Astros and Boston Red Sox meet Friday in MLB action at Fenway Park. Here’s a Red Sox vs. Astros Prediction. This article will include a Red Sox vs. Astros Pick.
Houston Astros Betting Preview
The Houston Astros are 12-20 on the year and play the Dodgers and Reds next. The Houston Astros are batting. 265 on the season, have a .346 OBP, and have a .438 slugging percentage. The Houston Astros pitching staff has a 6.08 ERA and a 1.64 WHIP. Yordan Alvarez leads the Houston Astros with 42 hits and 27 RBI while Carlos Correa and Christian Walker have combined for 63 hits and 38 RBI.
Mike Burrows gets the ball for the Houston Astros, and he is 1-3 with a 6.25 ERA and 33 strikeouts this season. Burrows is 1-0 with a 3.86 ERA and 8 strikeouts in his career against the Boston Red Sox.
Boston Red Sox Betting Preview
The Boston Red Sox are 12-19 on the year and play the Tigers and Rays next. The Boston Red Sox are batting .231 on the season, have a .309 OBP, and have a .351 slugging percentage. The Boston Red Sox pitching staff has a 4.35 ERA and a 1.31 WHIP. Wilyer Abreu leads the Boston Red Sox with 35 hits and 13 RBI, while Ceddanne Rafaela and Willson Contreras have combined for 53 hits and 30 RBI.
The Boston Red Sox didn’t announce a starting pitcher at the time this article was published.
Why the Boston Red Sox will win
- The Astros have lost each of their last 10 road games against teams that held a losing record.
- The home team has won eight of the last nine games between the Astros and Red Sox.
- The Astros have failed to cover the run line in nine of their last 10 road games against teams that held a losing record.
- The home team has covered the run line in each of the last four games between the Astros and Red Sox.
- The Red Sox have led after 3 innings in each of their last five night games against AL West opponents that held a losing record.
- The Astros have trailed after 5 innings in nine of their last 10 road games against opponents that held a losing record.
- The Astros have lost the first inning in six of their last seven road games against opponents that held a losing record.
Why the Houston Astros will win
- The Astros have won seven of their last eight games as underdogs against the Red Sox following a road win.
- The Red Sox have lost each of their last seven night games against American League opponents following a loss.
- The Red Sox have failed to cover the run line in each of their last eight night games against American League opponents following a loss.
- The Astros have covered the run line in each of their last seven games against the Red Sox following a road win.
- The Astros have led after 3 innings in six of their last seven night games against the Red Sox.
- The Red Sox have trailed after 5 innings in seven of their last eight night games at Fenway Park against AL West opponents.
- The Astros have won the first inning in each of their last four games against the Red Sox.
Total Runs Facts
- Each of the Astros’ last six games as underdogs against the Red Sox have gone OVER the total runs line.
- Seven of the Red Sox’s last eight games as favorites against the Astros have gone OVER the total runs line.
- The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Astros’ last 12 night games.
- The ‘Inning 1 OVER 0.5 runs’ market has hit in nine of the Red Sox’s last 10 games against AL West opponents.
Boston Red Sox Player Prop Facts
- Jarren Duran has recorded at least one hit in each of the Red Sox’s last eight night games against AL West opponents that held a losing record.
- Triston Casas has hit a home run in four of his last five home appearances against AL West opponents.
Houston Astros Player Prop Facts
- Yordan Alvarez has recorded at least one hit in each of the Astros’ last 12 night games.
- Yordan Alvarez has hit at least one home run in four of his last five appearances with the Astros as road underdogs against the Red Sox.
Matchup/League Facts
- The Red Sox rank 29th in the league for home runs this season (21).
- The Red Sox rank 29th in the league for slugging percentage this season (.351).
- The Astros rank 1st in the league for doubles this season (66).
- The Astros rank 30th in the league for ERA this season (6.08).
Red Sox vs Astros Prediction
I don’t care who the Red Sox are throwing out on the mound. I’m going to continue fading the Astros and this deplorable pitching staff. Burrows is not exempt from this mess with his 6.25 ERA and 1.67 WHIP through 31.2 innings. It’s every night with this group. The Astros pitching staff is enough for me to keep betting against them. Cheap price. Give me the Red Sox regardless of who takes the bump.