Red Sox vs Cardinals Prediction 4/6/25 MLB Picks Today

In this article we will formulate a Red Sox vs Cardinals prediction for this MLB game on Sunday, April 6th at Fenway Park in Boston, Massachusetts. Let’s take a look at the prediction for this MLB doubleheader. 

St. Louis Cardinals Betting Preview

The St. Louis Cardinals are 4-3 this year after they lost game one in this series by a score of 13-9 on Friday. St. Louis allowed five runs in the first inning, but did cut the lead to 6-5 and 8-6, before allowing Boston to pull away in the loss. The Cardinals recorded 13 hits in the game and they were led by Donovan and Herrera, who both had three RBIs in the loss. St. Louis started Fedde, who allowed five hits and six earned runs over 3.0 innings, while Matz, Fernandez, and King combined to allow seven earned runs out of the bullpen. 

Prior to this series, the Cardinals lost two out of three against the Angels and swept the Twins in three games. The St. Louis pitching staff has a 4.85 ERA with a 1.12 WHIP and a .220 opponent batting average, while their offense has scored 51 runs with a .302 batting average and a .377 on base percentage this season. Ivan Herrera has led St. Louis with four home runs and 11 RBIs, while Lars Nootbaar has added two home runs and six RBIs this year. The projected starting pitcher for St. Louis in game one is Andre Pallante, who 1-0 with a 3.60 ERA and a 1.20 WHIP over 5.0 innings pitched this season. The projected starter for game two is Miles Mikolas, who is 0-0 with a 3.38 ERA and a 0.75 WHIP over 5.1 innings pitched this year. 

Boston Red Sox Betting Preview

The Boston Red Sox are 4-4 this season after they exploded for 13 runs in the game one win on Friday. Boston scored five runs in the first inning and added five more in the seventh/eighth to pull away in the win. The Red Sox recorded 16 hits and committed three errors in the game, while they were led by Story, who went 2-5 with one home run and three RBIs in the win. Boston started Buehler, who allowed seven hits and five earned runs over 5.0 innings, while Chapman came in to get the final two outs for the save. 

Prior to this series, the Red Sox won two out of three against the Orioles and lost three out of four against the Rangers. The Boston pitching staff has a 4.24 ERA with a 1.25 WHIP and a .268 opponent batting average, while their offense has scored 40 runs with a .256 batting average and a .335 on base percentage this season. Wilyer Abreu has led Boston with three home runs and eight RBIs, while Kristian Campbell has added two home runs and five RBIs this year. The projected starting pitcher for game one is Sean Newcomb, who is 0-1 with a 9.00 ERA and a 2.50 WHIP over 4.0 innings pitched this year. The projected starting pitcher for Boston in game two is Richard Fitts, who is 0-1 with a 4.50 ERA and a 1.00 WHIP over 6.0 innings pitched this season. 

Why the Red Sox will beat the Cardinals

• The Red Sox have won each of their last 10 Sunday day games against NL Central opponents.
• The Cardinals have lost each of their last four road games against American League opponents.
• The Red Sox have covered the run line each of their last five games against teams that held a winning record.
• The Cardinals have failed to cover the run line in three of their last four games.
• The Cardinals have lost the first inning in each of their last three day games against American League opponents.
• The Red Sox have led after 3 innings in four of their last five home day games.
• The Red Sox have led after 5 innings in seven of their last eight home games against opponents that held a winning record.

Why the Cardinals will beat the Red Sox

• The Red Sox have lost nine of their last 10 games against National League opponents that held a winning record.
• The Cardinals have won five of their last six day games against American League opponents.
• The Red Sox have failed to cover the run line in each of their last six home games against NL Central opponents following a home win.
• The Cardinals have covered the run line in each of their last eight Sunday day road games.
• The Red Sox have trailed after 3 innings in three of their last four games against National League opponents that held a winning record.
• The Red Sox have trailed after 5 innings in six of their last eight games against National League opponents that held a winning record.

Total Runs Facts

• Nine of the last 10 games between the Cardinals and Red Sox have gone OVER the total runs line.
• Each of the Cardinals’ last five games have gone OVER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in seven of the Cardinals’ last eight day games.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the last four games between the Cardinals and Red Sox at Fenway Park.

Boston Red Sox Player Prop Facts

• Rafael Devers has recorded at least one RBI in each of the Red Sox’s last seven games against the Cardinals.
• Alex Bregman has recorded at least one hit in each of his 11 previous appearances in day games against NL Central teams that held a winning record.
• Alex Bregman has scored at least one run in each of his last nine appearances at Fenway Park against opponents that held a winning record.
• Trevor Story has hit a home run in three of his last four appearances in day games against NL Central teams that held a winning record.
• Alex Bregman has recorded at least one Single in each of his last six appearances against opponents that held a winning record.
• Alex Bregman has recorded a Double in four of his last five appearances at Fenway Park against opponents that held a winning record.

St. Louis Cardinals Player Prop Facts

• Lars Nootbaar has recorded at least one RBI in each of his last four appearances after not playing the previous day.
• Nolan Arenado has recorded at least one hit in each of his last 13 appearances.
• Masyn Winn has scored at least one run in each of his last six road appearances.
• Nolan Arenado has hit a home run in three of the Cardinals’ last four road games against the Red Sox.
• Brendan Donovan has recorded at least one Single in eight of the Cardinals’ last nine day games.
• Nolan Arenado has recorded a Double in three of his last four appearances after not playing the previous day.

Red Sox vs Cardinals Prediction 

Boston was able to offset a rough pitching day with a 13-run outburst to get the win on Friday, and they have scored 21 runs in their last two games. The Red Sox have won three games in a row and have really relied on their high scoring offense in those wins. St. Louis has lost three of their last four games and they have allowed 27 runs in those three losses. I think the Cardinals have the advantage in game one, as I don’t love Newcomb on the mound, while I will look at the over in game two, as neither pitcher impresses me against these solid lineups.