Red Sox vs Giants Prediction 6/21/25 MLB Picks Today

The Boston Red Sox are visiting the San Francisco Giants on Saturday, June 21^st at the Oracle Park in the second game of this series, with the Red Sox having the 1-0 lead. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Red Sox vs Giants Prediction. We will examine:

The San Francisco Giants recent form and player performance

The Boston Red Sox recent form and player performance

Recent betting trends and streaks involving the San Francisco Giants

Recent betting trends and streaks involving the Boston Red Sox

Recent betting trends in games played between the Boston Red Sox vs San Francisco Giants

A summary that ties it all together and produces a favorable betting outcome for the Boston Red Sox vs San Francisco Giants game

San Francisco Giants Preview

The San Francisco Giants have a 42-34 record this season and are sitting on the second place of the NL West. They have a 23-14 home record and are 35-39 in over/under. They are coming off a 5-7 home defeat by the Red Sox, and are 1-5 in their last 6 games. Under is 3-1-1 in their last 5 games, and are playing the White Sox and the Marlins next.

The Giants have a .232 batting average this season, .313 OBP and .372 Slugging percentage. San Francisco’s pitching staff has a 3.27 ERA and 1.22 WHIP.  Heliot Ramos leads the Giants with 80 hits and is the team’s best hitter, with a .283 batting average. Wilmer Flores leads the team in RBI with 54, while Matt Chapman leads the team in home runs, with 12.

Landen Roupp (R) is the projected starting pitcher for the Giants, and he has a 4-5 record, 3.99 ERA and 1.46 WHIP. He has been better at home, with a 2.25 ERA across five home games but he is coming off his worst start of the season, having given up 6 runs in just 1.2 innings pitched against the Dodgers. This will be his first career start against the Red Sox.

Boston Red Sox Preview

The Boston Red Sox have a 40-37 record this season and are sitting on the 4^th place of the AL East. The Red Sox have a 18-20 road record and are 35-41 in over/under. They are coming off a 7-5 road victory over the Giants and are 8-1 in their last 9 games. They are 7-2 to the under in their last 9 games and are playing the Blue Jays and the Angels next.

The Red Sox have a .249 batting average this season, .323 OBP and .417 slugging percentage. Boston’s pitching staff has a 3.93 ERA and 1.32 WHIP.  Jarren Duran leads the Red Sox with 84 hits, adding a team-high 38 RBI, while being the team’s best hitter, with a .260 batting average.

Brayan Bello (R) is the projected starting pitcher for the Red Sox, and he has a 3-1 record, 3.49 ERA and 1.47 WHIP. He has been good on the road, with a 3.52 ERA across three road starts, and he is coming off a shutout start against the Yankees in 7 innings pitched. This will be his first career start against the Giants.

Why the San Francisco Giants will win

• The Red Sox have lost eight of their last nine day games against NL West opponents.
• The Giants have won seven of their last eight home games against American League opponents following a home loss.
• The Red Sox have failed to cover the run line in each of their last eight day games against NL West opponents following a win.
• The Giants have covered the run line in each of their last three games against the Red Sox following a home loss.
• The Red Sox have lost the first inning in each of their last three games as underdogs against National League opponents.
• The Red Sox have trailed after 3 innings in each of their last six road games against National League opponents that held a winning record.
• The Red Sox have trailed after 5 innings in four of their last five road games against National League opponents that held a winning record.

Why the Boston Red Sox will win

• The Giants have lost five of their last six games as favorites against American League opponents.
• The Red Sox have won four of their last five games as underdogs.
• The underdogs have covered the run line in each of the Giants’ last 16 games at Oracle Park.
• The Giants have failed to cover the run line in each of their last 13 games as home favorites.
• The Giants have trailed after 3 innings in four of their last five home games against American League opponents that held a winning record.
• The Giants have trailed after 5 innings in each of their last five day games against American League opponents.
• The Giants have lost the first inning in four of their last five day games against AL East opponents.

Total Runs Facts

• Each of the Giants’ last nine games against AL East opponents have gone OVER the total runs line.
• Six of the Red Sox’s last seven games after playing the previous day have gone UNDER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in eight of the Giants’ last nine games against AL East opponents.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Red Sox’s last four games against National League opponents.

Matchup/League Facts

• The Giants rank 2nd in the league for home runs allowed this season (59).
• The Giants rank 3rd in the league for walks this season (277).
• The Red Sox rank 1st in the league for doubles this season (144).
• The Red Sox rank 28th in the league for strikeouts against this season (714).

Red Sox vs Giants Prediction

The Red Sox are 3-1 in their last 4 overall meetings against the Giants, and both teams are tied 2-2 wins in their last 4 meetings in San Francisco. Under is 6-1 in their last 7 meetings.

In this Red Sox vs Giants Prediction, the Giants are coming as -135 home favorites. Both teams have almost identical overall record, but the Giants have been very strong at home, while the Red Sox are below average on the road. the Giants have the best bullpen in the league and the are better against righties, while the Red Sox are weaker against right-handed pitching. Roupp has been excellent at home for the Giants, so I expect them to bounce back at home in this one and even the series.