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Red Sox vs Orioles Prediction 7/22/26 MLB Picks Today

Baltimore Orioles (49-52) vs. Boston Red Sox (51-48)
July 22, 2026 1:35 pm EDT
The Line: Boston Red Sox -143 / Baltimore Orioles 119; Over/Under: 9
(Get latest betting odds)

In this article we will formulate a Red Sox vs Orioles prediction for this MLB game on Wednesday, July 22nd at Fenway Park in Boston, Massachusetts. Let’s take a look at the prediction for this MLB matchup. 

Boston Red Sox Betting Preview

The Boston Red Sox are 51-48 this year after they won game one by a score of 6-5 on Monday night. Boston trailed 5-4 in the seventh inning, but they scored once in the seventh and once in the eighth for the win. The Red Sox recorded 10 hits in the game and they were led by Contreras, who went 3-4 with two RBIs. Tolle allowed eight hits and four earned runs over 5.2 innings, while Whitlock picked up the win and Chapman got the save. Prior to this series, Boston swept the Rays in four games and swept the Mets in three games. 

This season, Boston has a 3.55 ERA with a 1.22 WHIP and a .237 opponent batting average, while they have scored 419 runs with a .245 batting average and a .315 on base percentage. Willson Contreras has led the Red Sox with 22 home runs and 66 RBIs, while Jarren Duran has added 13 home runs and 49 RBIs. The projected starter for game one Jake Bennett, who is 5-3 with a 2.35 ERA and a 0.88 WHIP over 53.2 innings pitched. The projected starting pitcher for Boston in game two is Ranger Suarez, who is 4-3 with a 3.15 ERA and a 1.16 WHIP over 91.1 innings pitched this year. 

Baltimore Orioles Betting Preview

The Baltimore Orioles are 49-52 this season after they lost game one by a score of 5-6 on Monday. Baltimore led 1-0 in the first inning, 4-3 in the sixth, and 5-4 in the seventh, but couldn’t hold on for the loss. The Orioles recorded 11 hits and they committed four errors in the game, while they were led by O’Neill, who went 2-5 with two RBIs. Baz allowed seven hits and two earned runs over 6.0 innings, while Wells picked up the loss in relief. Prior to this series, Baltimore swept the Astros in four games and swept the Royals in three games. 

This season, Baltimore has a 4.21 ERA with a 1.35 WHIP and a .252 opponent batting average, while they have scored 464 runs with a .238 batting average and a .321 on base percentage. Pete Alonso has led the Orioles with 21 home runs and 66 RBIs, while Gunnar Henderson has added 17 home runs and 44 RBIs. The projected starting pitcher for Baltimore in game one is Dean Kremer, who is 1-2 with a 4.15 ERA and a 1.12 WHIP over 26.0 innings pitched this season. The projected starter for game two is Kyle Bradish, who is 6-9 with a 3.61 ERA and a 1.35 WHIP over 107.1 innings pitched. 

Why the Boston Red Sox will win

  • The Red Sox have won each of their last 15 games against American League opponents.
  • The Orioles have lost each of their last 14 road games against AL East opponents that held a winning record.
  • The Orioles have failed to cover the run line in seven of their last eight road games against AL East opponents that held a winning record.
  • The Red Sox have covered the run line in each of their last six Wednesday day games as favorites against AL East opponents.
  • The Red Sox have led after 5 innings in 14 of their last 15 games against American League opponents.
  • The Red Sox have led after 3 innings in each of their last nine games as favorites against American League opponents.

Why the Baltimore Orioles will win

  • The Red Sox have lost four of their last five games as home favorites against the Orioles following a win.
  • The Orioles have won each of their last three games as road underdogs against the Red Sox following a loss.
  • The Orioles have covered the run line in each of their last eight games as road underdogs.
  • The Red Sox have failed to cover the run line in 10 of their last 11 home games against AL East opponents that held a losing record.
  • The Orioles have led after 5 innings in each of their last five day games against the Red Sox at Fenway Park.
  • The Red Sox have lost the first inning in four of their last five day games against American League opponents that held a losing record.
  • The Red Sox have trailed after 3 innings in four of their last five home games against opponents that held a losing record.

Total Runs Facts

  • Each of the Orioles’ last four games against AL East opponents have gone OVER the total runs line.
  • Seven of the Red Sox’s last nine games as favorites against the Orioles have gone UNDER the total runs line.
  • There has been no run scored during the first inning in seven of the Orioles’ last eight day games against AL East opponents.
  • There has been at least one run scored in the first inning in each of the last four games between the Orioles and Red Sox.

Boston Red Sox Player Prop Facts

  • Willson Contreras has hit a home run in three of the Red Sox’s last four day games against AL East opponents that held a losing record.
  • Ceddanne Rafaela has recorded at least one hit in each of the Red Sox’s last 11 games as favorites.

Baltimore Orioles Player Prop Facts

  • Christian Encarnacion-Strand has hit a home run in each of his last two appearances against the Red Sox.
  • Pete Alonso has recorded at least one hit in each of his nine previous appearances with his team as an underdog against the Red Sox.

Matchup/League Facts

  • The Red Sox rank T1st in the league for runs allowed this season (373).
  • The Red Sox rank T1st in the league for runs allowed this season (373).
  • The Orioles rank 28th in the league for strikeouts against this season (933).
  • The Orioles rank 28th in the league for strikeouts against this season (933).

Red Sox vs Orioles Prediction 

Boston comes into this doubleheader looking to extend their lengthy winning streak and they have scored 6+ runs in four of their last five games. The Red Sox are 22-27 at home this year, while the Orioles are 21-27 on the road. Baltimore had their winning streak snapped in game one, but they have allowed two runs or fewer in four straight games. In game one, Bennett has been elite for the Red Sox, so I like them to win. In game two, Bradish has been pretty reliable, so I like the Orioles to win. 

David Racey's Free Pick: Game 1: Red Sox ML Game 2: Orioles ML

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David Racey

David started writing about sports in 2015, but sports has been his passion for as long as he can remember. David spends most of his free time watching pretty much anything sports related from Baseball to Tennis and everything in between. David likes to analyze statistics and recent results to form an unbiased opinion on whatever game he is breaking down. Follow David on Twitter at @itsyerboi41

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