Reds vs Cardinals Prediction 4/28/25 MLB Picks Today

The St. Louis Cardinals and Cincinnati Reds meet Monday in MLB action at Great American Ball Park. Here’s a Reds vs Cardinals Prediction. This article will include a Reds vs Cardinals Pick.

St. Louis Cardinals Betting Preview

The St. Louis Cardinals are 12-16 on the year and play the Mets, Pirates, and Nationals next. The St. Louis Cardinals are batting .265 on the season, have a .336 OBP, and a .401 slugging percentage. The St. Louis Cardinals pitching staff has a 4.36 ERA and a 1.25 WHIP. Brendan Donovan leads the St. Louis Cardinals with 37 hits and 16 RBI, while Lars Nootbaar and Nolan Arenado have combined for 53 hits and 29 RBI.

Andre Pallante gets the ball for the St. Louis Cardinals, and he is 2-1 with a 4.05 ERA and 16 strikeouts this season. Pallante is 5-1 with a 1.83 ERA and 32 strikeouts in his career against the Cincinnati Reds.

Cincinnati Reds Betting Preview

The Cincinnati Reds are 15-13 on the year and play the Nationals, Braves, and Astros next. The Cincinnati Reds are batting .254 on the season, have a .333 OBP, and a .404 slugging percentage. The Cincinnati Reds pitching staff has a 3.46 ERA and a 1.10 WHIP. TJ Friedl leads the Cincinnati Reds with 32 hits and 12 RBI while Elly De La Cruz and Gavin Lux have combined for 59 hits and 37 RBI.

Nick Martinez gets the ball for the Cincinnati Reds, and he is 0-3 with a 5.40 ERA and 23 strikeouts this season. Martinez is 0-2 with a 3.72 ERA and 6 strikeouts in his career against the St. Louis Cardinals.

Why the Cincinnati Reds will win

• The Reds have won each of their last nine Monday home games against NL Central opponents.
• The Cardinals have lost seven of their last eight road games.
• The Reds have covered the run line in each of their last nine night games against NL Central opponents.
• The Cardinals have failed to cover the run line in each of their last six night games against the Reds following a loss.
• The Reds have led after 3 innings in seven of their last eight home games against National League opponents that held a losing record.
• The Reds have led after 5 innings in 14 of their last 15 Monday home games.

Why the St. Louis Cardinals will win

• The Cardinals have won eight of their last nine games as underdogs against NL Central opponents following a loss.
• The Reds have lost five of their last six games as favorites against NL Central opponents following a road win.
• The Cardinals have covered the run line in 13 of their last 14 games as underdogs following a home loss.
• The Reds have failed to cover the run line in five of their last six games as home favorites following a road win.
• The Cardinals have led after 5 innings in three of their last four games.

Cincinnati Reds Player Prop Facts

• Elly De La Cruz has recorded at least one Single in each of the Reds’ last eight games as favorites.
• Tyler Stephenson has hit a home run in each of his last two appearances in night games against teams that held a losing record.
• Tyler Stephenson has recorded at least one hit in each of his last 14 appearances in night games against teams that held a losing record.
• Tyler Stephenson has scored at least one run in each of his last eight appearances in night games against NL teams that held a losing record.
• Jose Trevino has recorded a Double in four of his last five appearances in night games.
• Tyler Stephenson has recorded at least one RBI in seven of his last eight appearances in night games against teams that held a losing record.
• Elly De La Cruz ranks 3rd in the league in Steals (11) this season.

St. Louis Cardinals Player Prop Facts

• Willson Contreras has hit a home run in each of his last two appearances at Great American Ball Park against NL Central opponents that held a winning record.
• Brendan Donovan has recorded a Double in four of the Cardinals’ last five games as underdogs against NL Central opponents.
• Brendan Donovan has recorded at least one RBI in seven of the Cardinals’ last eight games against NL Central opponents.
• Masyn Winn has scored at least one run in each of his last six appearances in night games against NL teams that held a winning record.
• Masyn Winn has recorded at least one Single in each of his last eight appearances with the Cardinals as road underdogs.
• Brendan Donovan has recorded at least one hit in each of the Cardinals’ last 16 games against NL Central opponents.
• Brendan Donovan ranks T3rd in the league in Hits (37) this season.

Reds vs Cardinals Prediction

The Reds are going to get some love here, as they’ve won four straight games. Let’s pump the breaks however, as those wins came against the Marlins and Rockies. I’m not ready to say the Reds have figured things out. Martinez has been hittable all year, as he’s allowed 28 hits and 16 earned runs in 26.2 innings. Pallante has had his issues as well, but they’re not nearly as shaky as Martinez. Also, Pallante has owned the Reds over his career, which includes holding current batters to a .188 batting average and 13 strikeouts in 64 at bats. I need to see more from the Reds. I’ll take the plus money with the Cardinals on Monday night.