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Reds vs Cardinals Prediction 5/1/25 MLB Picks Today

St. Louis Cardinals (14-17) vs. Cincinnati Reds (16-15)
May 1, 2025 12:40 pm EDT
The Line: Cincinnati Reds -122 / St. Louis Cardinals 102; Over/Under: 9
(Get latest betting odds)

In this article, we will formulate a Reds vs Cardinals Prediction for this MLB game on Thursday, May 1st, at Citi Field. Let’s take a look at a Cincinnati Reds vs St. Louis Cardinals pick. 

What a Win for the Cardinals

It hasn’t been the best season for the Cardinals, but they are coming off a victory on Wednesday. The Cardinals scored nine runs, and that was enough for the eight-run victory. Wilson Contreras hit a home run and drove in three RBIs. Steven Matz got the start, and he went four innings, giving up five hits and zero runs. The Cardinals only used two pitchers, which could help them here. 


The Cardinals are averaging 4.52 runs while their pitching is giving up 4.65 runs per game. The offense is ranked 12th while the pitching is ranked 22nd. Lars Nootbaar has had a strong season, hitting four home runs and driving in 17 RBIs. Matthew Liberatore currently sits with a 2-2 record and an ERA of 3.19. Against the Milwaukee Brewers, he went six innings, giving up five hits and one earned run. 

Bad Loss for the Reds

It was a bad loss for the Reds on Wednesday. The Reds were only outhit by one, but they also only had one run cross the plate, and that led to the defeat. Santiago Espinal was the only real bright spot for the offense, finishing with three hits and one RBI. Chase Petty got the start, and he went 2.1 innings, giving up seven hits and nine earned runs. He had three strikeouts and two walks. 

The Reds are averaging 5.28 runs while their pitching is giving up 3.79 runs per game. The offense is ranked 3rd while the pitching is ranked 9th. Elly De La Cruz has hit five home runs and driven in 24 RBIs. Getting the start for the Reds will be Andrew Abbott, who sits with a 2-0 record and an ERA of 3.60. Against the Colorado Rockies in his last start, he went four innings, giving up five hits and four runs. 

Reds vs Cardinals Prediction

The Cardinals have some value here, even if they haven’t been that good this season. Andrew Abbott, in his last start, struggled, giving up five hits and four runs, and I believe the Cardinals’ offense is going to find success here. Matthew Liberatore has been good this season, and he’s going to step up again in a major way here. The Reds are going to score only a run or two off Liberatore, and the Cardinals are going to get the job done. Back the Cardinals on the money line. 

Shane Mickle's Free Pick: Cardinals ML +102

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Shane Mickle

Sports is about all Shane knows in this life! He has a passion for sports and writing, which makes working for Sportschatplace a perfect job for him! If you find him cheering for a team it's usually a Minnesota team, or the Kansas Jayhawks!

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