MLB Picks

Reds vs Cubs Prediction 5/23/25 MLB Picks Today

Chicago Cubs (30-20) vs. Cincinnati Reds (25-26)
May 23, 2025 6:40 pm EDT
The Line: Cincinnati Reds -105 / Chicago Cubs -115; Over/Under: 8.5
(Get latest betting odds)

The Chicago Cubs and Cincinnati Reds meet Friday in MLB action at Great American Ball Park. Here’s a Great American Ball Park. This article will include a Reds vs Cubs Pick.

Chicago Cubs Betting Preview

The Chicago Cubs are 30-20 on the year and play the Rockies, Reds, and Nationals next. The Chicago Cubs are batting .261 on the season, have a .335 OBP, and a .447 slugging percentage. The Chicago Cubs pitching staff has a 3.90 ERA and a 1.28 WHIP. Pete Crow-Armstrong leads the Chicago Cubs with 55 hits and 39 RBI, while Kyle Tucker and Nico Hoerner have combined for 106 hits and 57 RBI.


Matthew Boyd gets the ball for the Chicago Cubs, and he is 4-2 with a 2.98 ERA and 53 strikeouts this season. Boyd is 1-3 with a 6.00 ERA and 20 strikeouts in his career against the Cincinnati Reds.

Cincinnati Reds Betting Preview

The Cincinnati Reds are 25-26 on the year and play the Royals, Cubs, and Brewers next. The Cincinnati Reds are batting .241 on the season, have a .317 OBP, and a .391 slugging percentage. The Cincinnati Reds pitching staff has a 3.48 ERA and a 1.17 WHIP. TJ Friedl leads the Cincinnati Reds with 49 hits and 18 RBI, while Elly De La Cruz and Gavin Lux have combined for 93 hits and 53 RBI.

Hunter Greene gets the ball for the Cincinnati Reds, and he is 4-2 with a 2.36 ERA and 61 strikeouts this season. Greene is 4-1 with a 4.06 ERA and 46 strikeouts in his career against the Chicago Cubs.

Why the Cincinnati Reds will win

  • The Cubs have lost seven of their last eight games as road favorites against the Reds following a road win.
  • The Reds have won each of their last five games as home underdogs following a road loss.
  • The Reds have covered the run line in each of their last eight games as home underdogs against NL Central opponents.
  • The Cubs have failed to cover the run line in each of their last eight games as favorites against the Reds following a road win.
  • The Reds have led after 3 innings in seven of their last eight games as home underdogs against NL Central opponents.
  • The Reds have led after 5 innings in five of their last six games against opponents that held a winning record.

Why the Chicago Cubs will win

  • The Reds have lost each of their last six Friday games against National League opponents that held a winning record.
  • The Cubs have won five of their last six games.
  • The Reds have failed to cover the run line in five of their last six games as home underdogs against National League opponents.
  • The Cubs have covered the run line in eight of their last 10 road games against NL Central opponents.
  • The Reds have lost the first inning in three of their last four home games against NL Central opponents.
  • The Cubs have led after 5 innings in nine of their last 10 night games against NL Central opponents.
  • The Reds have trailed after 3 innings in three of their last four home games against National League opponents that held a winning record.

Cincinnati Reds Player Prop Facts

  • Tyler Stephenson has recorded at least one Single in seven of his last eight home appearances against opponents that held a winning record.
  • Hunter Greene has recorded seven or more strikeouts in eight of his last nine home appearances.
  • Spencer Steer has recorded at least one hit in each of the Reds’ last 11 home games.
  • Will Benson has hit at least one home run in each of the Reds’ last four home games.
  • Will Benson has scored at least one run in each of the Reds’ last four home games.
  • Gavin Lux has recorded at least one Double in each of his last three appearances in night games.
  • Hunter Greene has recorded a win in each of his last five appearances in night games against teams that held a winning record.
  • Will Benson has recorded at least one RBI in each of the Reds’ last four games against opponents that held a winning record.
  • Elly De La Cruz ranks T3rd in the league in Steals (16) this season.

Chicago Cubs Player Prop Facts

  • Dansby Swanson has hit a home run in six of the Cubs’ last eight night games against NL Central opponents that held a losing record.
  • Dansby Swanson has recorded at least one Double in four of the Cubs’ last five games at Great American Ball Park against opponents that held a losing record.
  • Matthew Boyd has recorded a win in three of his last four appearances with the Cubs as favorites.
  • Kyle Tucker has recorded at least one RBI in seven of his eight previous road appearances against NL Central opponents that held a losing record.
  • Matthew Boyd has recorded seven or more strikeouts in each of his last three appearances.
  • Ian Happ has scored at least one run in eight of his last nine appearances in night games against teams that held a losing record.
  • Carson Kelly has recorded at least one Single in each of his last seven appearances with his team as a road favorite against NL opponents.
  • Dansby Swanson has recorded at least one hit in each of the Cubs’ last 16 road games against NL opponents that held a losing record.
  • Pete Crow-Armstrong ranks T6th in the league in Steals (14) this season.

Reds vs Cubs Prediction

The Cubs are having a strong week, and Boyd has been good this season with a 2.98 ERA and 1.23 WHIP. However, the Reds are due for a breakout performance offensively after being held to one run in their last two games. Greene has also turned into a star pitcher, and that includes allowing four hits and one run in his last nine innings.

Greene has missed the last couple of weeks due to the IL, but he’s been dealing all year with his 2.36 ERA and 0.81 WHIP through 45.2 innings. The Reds have won five of the last six games Greene has pitched. Give me the Reds at home with the cheap price and their ace on the mound.

Randy Chambers's Free Pick: Cincinnati Reds -105

Need More? Get Premium Picks

Randy Chambers

Randy has covered sports betting since 2014 and writes about everything from NFL to WNBA. Follow Randy Chambers on Twitter.

Related Articles

Back to top button