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Reds vs Giants Prediction 3/27/25 MLB Picks Today

San Francisco Giants (0-0) vs. Cincinnati Reds (0-0)
March 27, 2025 4:10 pm EDT
The Line: Cincinnati Reds / San Francisco Giants ; Over/Under:
(Get latest betting odds)

In this article, we will formulate a Reds vs Giants prediction for this MLB game on Thursday, March 27th, at Great American Ball Park in Cincinnati, Ohio. Let’s take a look at the prediction for this MLB matchup.

San Francisco Giants Betting Preview

The San Francisco Giants finished the last season with an 80-82 record and in 4th place in the NL West. They were exceptional during this spring training, after winning 21 and losing just six games; the Giants won eight of the final ten games (one tie).


Last year, the Giants averaged 4.28 runs per game (17th in the MLB) on a .239/.305/.396 slash line. The Giants’ pitching staff had a 4.10 ERA (19th) and 1.30 WHIP (22nd). Matt Chapman was the best offensive player for the Giants, with a .247 batting average, 27 home runs, and 78 RBI last season.

Logan Webb will take the mound for the Giants on Thursday. The 28-year-old righty had a 13-10 record in 2024 with a 3.47 ERA and 1.23 WHIP over 614.0 innings.

Cincinnati Reds Betting Preview

The Cincinnati Reds ended the last year with a 77-85 record and in fourth place in the NL Central, with a win ahead of the Pittsburgh Pirates. The Red destroyed the Cleveland Guardians 13-2 in the final game of the spring training, which they finished with a 12-17 record.

Last season, the Reds averaged 4.31 runs per game (16th in the MLB) on a .231/.305/.388 triple-slash. When it comes to pitching, Cincinnati’s staff had a 4.09 ERA (18th) and 1.25 WHIP (16th). On offense, Elly De La Cruz had an excellent season for the Reds with a .259 batting average, 25 home runs, and 76 RBI last season.

The projected starting pitcher for the Reds is Hunter Greene, who went 9-5 with a 2.75 ERA and a 1.02 WHIP over 451.0 innings pitched in 2024.

Why the Reds will beat the Giants

  • The Giants have lost five of their last six road openers.
  • The Reds have won 10 of their last 13 games against NL West opponents.
  • The Giants have failed to cover the run line in seven of their last eight season openers.
  • The Reds have covered the run line in six of their last eight day games against NL West opponents.
  • The Giants have trailed after 3 innings in five of their last six day games against NL Central opponents.

Total Runs Facts

  • Eight of the Reds’ last nine day games against National League opponents have gone UNDER the total runs line.
  • Four of the Giants’ last five games have gone OVER the total runs line.
  • The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Reds’ last seven games against NL West opponents.
  • The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Giants’ last five games at Great American Ball Park.

Reds vs Giants Prediction

The Giants won six of the previous ten H2H encounters, including four of the last five. It’s going to be a tight affair, and it could go either way, but I am giving a slight advantage to the Reds, who are playing at home and who have a slightly better starter. Greene has a favorable matchup against the Giants’ batters; in 45 at-bats in his career, he allowed just a 1.33 BA, two homers, and four RBI against the Giants. Mainly because of Greene, I am backing the Reds in this one.

Oliver Zivic's Free Pick: Reds ML

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Oliver Zivic

Professional journalist and expert bettor with 20+ years of experience. I cover Football (soccer), NFL, NBA, NHL, MLB, CFB, and CBB.

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