Reds vs Padres Prediction 9/2/26 MLB Picks Today
San Diego Padres (73-66) vs. Cincinnati Reds (66-73)
September 2, 2026 12:40 pm EDT
The Line: Cincinnati Reds 123 / San Diego Padres -149; Over/Under: 9.5
(Get latest betting odds)
The San Diego Padres and Cincinnati Reds meet Wednesday in MLB action at Great American Ball Park. Here’s a Reds vs Padres Prediction. This article will include a Reds vs Padres Pick.
San Diego Padres Betting Preview
The San Diego Padres are 73-66 on the year and play the Nationals and Yankees next. The San Diego Padres are batting .238 on the season, have a .315 OBP, and have a .387 slugging percentage. The San Diego Padres’ pitching staff has a 3.91 ERA and a 1.29 WHIP. Fernando Tatis Jr. leads the San Diego Padres with 152 hits and 69 RBI, while Jackson Merrill and Manny Machado have combined for 239 hits and 145 RBI.
Casey Mize gets the ball for the San Diego Padres, and he is 5-8 with a 3.45 ERA and 96 strikeouts this season. This will be Mize’s second career game against the Cincinnati Reds.
Cincinnati Reds Betting Preview
The Cincinnati Reds are 66-73 on the year and play the Brewers and Dodgers next. The Cincinnati Reds are batting .228 on the season, have a .307 OBP, and have a .394 slugging percentage. The Cincinnati Reds’ pitching staff has a 4.66 ERA and a 1.42 WHIP. Sal Stewart leads the Cincinnati Reds with 143 hits and 105 RBI, while Elly De La Cruz and Tyler Stephenson have combined for 215 hits and 109 RBI.
Brandon Williamson gets the ball for the Cincinnati Reds, and he is 2-3 with a 6.11 ERA and 19 strikeouts this season. This will be Williamson’s second career game against the San Diego Padres.
Why the Cincinnati Reds will win
- The Reds have won four of their last six games as underdogs.
- The Padres have lost four of their last six games as favorites against NL opponents.
- The underdogs have covered the run line in four of the Padres’ last five games at Great American Ball Park.
- The Padres have failed to cover the run line in three of their last four road games against NL Central opponents.
Why the San Diego Padres will win
- The Reds have lost each of their last seven games against NL West opponents following a win.
- The Padres have won eight of their last nine days’ games against NL Central opponents that held a losing record.
- The Padres have covered the run line in each of their last 12 games following a road loss.
- The Reds have failed to cover the run line in each of their last nine Wednesday home games.
- The Padres have won the first inning in eight of their last 10 day games against NL Central opponents that held a losing record.
- The Padres have led after 3 innings in eight of their last 10 day games against NL Central opponents that held a losing record.
- The Reds have trailed after 5 innings in each of their last seven Wednesday home games.
Total Runs Facts
- Each of the Padres’ last nine games against NL opponents have gone UNDER the total runs line.
- Each of the Reds’ last five home games against NL West opponents have gone UNDER the total runs line.
- There has been no run scored during the first inning in each of the Padres’ last nine day games against NL opponents.
- There has been at least one run scored in the first inning in six of the Reds’ last seven day games at Great American Ball Park.
Cincinnati Reds Player Prop Facts
- Sal Stewart has hit a home run in each of the Reds’ last two day games.
- Brandon Williamson has recorded four or more strikeouts in four of his last five appearances against NL West opponents.
- Sal Stewart has recorded at least one hit in each of the Reds’ last 13 games against opponents that held a winning record.
- Sal Stewart ranks T9th in the league in Home Runs (31) this season.
San Diego Padres Player Prop Facts
- Fernando Tatis Jr. has hit at least one home run in two of the Padres’ last three games against the Reds.
- Casey Mize has recorded five or more strikeouts in four of his last five appearances with his team as a favorite against NL opponents.
- Samad Taylor has recorded at least one hit in each of his last 12 appearances against opponents that held a losing record.
- Fernando Tatis Jr. ranks 6th in the league in Hits (152) this season.
Matchup/League Facts
- The Reds rank 30th in the league for batting average this season (.228).
- The Reds rank 29th in the league for hits this season (1054).
- The Padres rank 3rd in the league for steals this season (138).
- The Padres rank T25th in the league for hits this season (1089).
Reds vs Padres Prediction
We’re getting a low price to back a Padres team that needs to keep winning to sneak into the playoffs. Mize has been solid through 109.2 innings with a 3.45 ERA and 1.10 WHIP. Williamson has just 28 innings, and he has a 6.11 ERA and 1.64 WHIP. Quick turnarounds usually favor the home team, but these are must-win spots for the Padres if they’re serious about postseason baseball. Give me the Padres.