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Royals vs Astros Prediction 4/25/25 MLB Picks Today

Houston Astros (13-11) vs. Kansas City Royals (11-14)
April 25, 2025 7:40 pm EDT
The Line: Kansas City Royals 102 / Houston Astros -122; Over/Under: 7.5
(Get latest betting odds)

In this article, we will formulate a Royals vs Astros  Prediction for this MLB game on Friday, April 25th, at Kaufmann Stadium. Let’s take a look at a Kansas City Royals vs Houston Astros pick. 

Royals Figuring It Out?

The Royals got out to a slow start to the season but they are suddenly figuring it out and they have won four games In a row. On Thursday they played a doubleheader and they secured two wins. In the second game, the pitching gave up only two runs, and that was enough for the four-run victory. Michael Lorenzen went six innings and gave up only five hits and one run.


The Royals are averaging 2.96 runs while their pitching is giving up 3.61 runs per game. The offense is ranked 30th while the pitching is ranked 8th. Salvador Perez has hit two home runs and driven in 10 RBIs. Getting the start for the Royals will be Seth Lugo, who sits with a 1-3 record and an ERA of 3.90. Against the Detroit Tigers he went 6.2 innings giving up five hits and three runs. 

Why the Royals Will Beat the Astros

  • The Astros have lost seven of their last eight games as road favorites following a home win.
  • The Royals have won each of their last 13 Friday home games against American League opponents.
  • The Royals have covered the run line in each of their last eight Friday night home games against American League opponents.
  • The Astros have failed to cover the run line in eight of their last nine games as road favorites following a home win.
  • The Astros have trailed after 5 innings in three of their last four night games against opponents that held a losing record.

Astros Figuring It Out?

The Astros appear like they might be figuring it out, and they are coming off a series sweep against the Toronto Blue Jays. On Wednesday, the Astros scored three runs and that was enough to secure the 3-1 victory. Ryan Gusto was on the mound and he went 5.2 innings giving up three hits and one run. Over the last three games the Astros have given up only one run total. 

The Astros are averaging 3.83 runs while their pitching is giving up 3.338 runs per game. The offense is ranked 22nd in the league but the last two games it’s actually been the pitching that they have really leaned on. Getting the start for the Astros will be Hayden Wesneski who sits with a 1-1 record and an ERA of 3.91. Against the San Diego Padres in his last start he went five innings giving up six hits and two runs. 

Why the Astros Will Beat the Royals

  • The Royals have lost each of their last eight night games against American League opponents.
  • The favorites have won each of the Royals’ last eight games at Kauffman Stadium.
  • The Astros have covered the run line in eight of their last nine night games against American League opponents.
  • The Royals have failed to cover the run line in seven of their last eight games as underdogs following a home win.
  • The Royals have trailed after 5 innings in five of their last six games as underdogs against AL West opponents.
  • The Royals have trailed after 3 innings in six of their last eight games as home underdogs against American League opponents.

Royals vs Astros Prediction

This game is going to be a good old-fashioned pitchers’ duel. The Astros pitching has been dominant heading into this game and the success is going to continue here. Wesneski gave up only two runs and he sits with an ERA of 3.91. Seth Lugo sits with a poor record but he has an ERA of 3.90 and the Astros offense isn’t going to be exactly elite here. Both starting pitchers are going to be strong here, and this game is going to stay under the total. This is one of my favorite plays on the board. 

Shane Mickle's Free Pick: Under

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Shane Mickle

Sports is about all Shane knows in this life! He has a passion for sports and writing, which makes working for Sportschatplace a perfect job for him! If you find him cheering for a team it's usually a Minnesota team, or the Kansas Jayhawks!

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