San Diego Padres vs Colorado Rockies Prediction 9/13/25 MLB Picks Today

The Colorado Rockies and the San Diego Padres meet Saturday in MLB action from Petco Park. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Colorado Rockies vs. San Diego Padres prediction.

Starting Pitching Matchup

The Colorado Rockies will start Bradley Blalock here and Blalock is 1-4 with an 8.62 ERA and 22 strikeouts this season. In his career, Blalock is 0-1 with a 12.54 ERA and 3 strikeouts against San Diego. Dylan Cease will get the nod for the Padres here and is 7-11 with a 4.71 ERA and 195 strikeouts this season. In his last five starts against the Rockies, Cease is 3-1 with a 3.86 ERA and 32 strikeouts.

Colorado Rockies Recap

The Colorado Rockies come into this game looking to add on to their 4-2 win over San Diego from Friday’s matchup to sit at 41-107 this season. After this series, the Rockies will make the trip back to Coors Field for a set against the Miami Marlins.

Rockies Snap Six-Game Losing Streak

Hunter Goodman leads the Rockies with 133 hits including 25 doubles, 4 triples, 29 home runs and 86 RBIs while Michael Toglia has 58 hits with 15 doubles, 11 home runs and 32 RBIs but also has 126 strikeouts. Kyle Farmer has 14 doubles while Jordan Beck has 15 home runs, 25 doubles, 50 RBIs, 5 triples and 16 stolen bases. Brenton Doyle has 110 hits with 20 doubles, 14 home runs, 55 RBIs and 16 stolen bases. Mickey Moniak has 100 hits with 17 doubles, 8 triples and 19 home runs with 57 RBIs. 

Why the Colorado Rockies will win

• The Padres have lost four of their last five games as home favorites following a loss.
• The underdogs have won six of the Padres’ last eight games at Petco Park.
• The Rockies have covered the run line in each of their last nine road games against National League opponents following a road win.
• The Padres have failed to cover the run line in eight of their last nine home games.

Colorado Rockies Player Prop Facts

• Brenton Doyle has hit a home run in six of the Rockies’ last 23 games against NL West opponents.
• Thairo Estrada has recorded at least one hit in each of his last nine appearances at Petco Park.
• Kyle Farmer has recorded at least one Double in three of his last four appearances against the Padres after playing the previous day.
• Hunter Goodman ranks 10th amongst qualified players for Slugging Percentage (.532) this season.

San Diego Padres Recap

The San Diego Padres come into this game looking to bounce back from their loss at the hands of the Rockies on Friday to drop to 81-67 this season. After this set, the Padres will travel to the Big Apple for a series against the New York Mets.

Padres Drop 3 Of Their Last 4

Manny Machado has 155 hits including a team-high 33 doubles, 23 home runs, 84 RBIs and 13 stolen bases while Fernando Tatis Jr. has 143 hits with 21 home runs and 63 RBIs along with 29 stolen bases of his own this season. Luis Arraez has added 159 hits with 29 doubles, 4 triples, 7 home runs and 54 RBIs while Jackson Merrill’s added 98 hits with 10 home runs and 55 RBIs as well. Xander Bogaerts also has 29 doubles and 20 stolen bases as well this season. Gavin Sheets also has 26 doubles, 19 home runs and 64 RBIs as well this season.

Why the San Diego Padres will win

• The Rockies have lost 12 of their last 13 night games after playing the previous day.
• The Padres have won each of their last six home games against NL West opponents following a home loss.
• The Rockies have failed to cover the run line in nine of their last 10 games after playing the previous day.
• The favorites have covered the run line in six of the Rockies’ last seven games.

San Diego Padres Player Prop Facts

• Jackson Merrill has hit a home run in two of the Padres’ last three games against the Rockies.
• Dylan Cease has recorded eight or more strikeouts in four of his last five home appearances against NL opponents.
• Xander Bogaerts has recorded a Double in three of his last four appearances in night games against teams that held a losing record.
• Dylan Cease has recorded a win in four of his last five appearances with the Padres as favorites.
• Fernando Tatis Jr. has recorded at least one hit in each of his last 11 Saturday appearances against NL West teams that held a losing record.
• Luis Arraez ranks 4th in the league in Hits (163) this season.

Total Runs Facts

• Each of the Padres’ last six games have gone UNDER the total runs line.
• Eight of the Rockies’ last 10 road games have gone UNDER the total runs line.

Colorado Rockies vs. San Diego Padres Prediction

I’m leaning towards the Padres here. I get the case to be made for the Rockies in some spots as the Rockies aren’t going to lose every game down the stretch. However, Cease has been far better at Petco Park this season and just stymied the Rockies in his last start, while Blalock has been crushed by the Padres in his career and has been getting crushed in his recent appearances as well. I’ll back the Padres in this one.