Chicago White Sox vs Cleveland Guardians Prediction 6/24/26 MLB Picks Today

The Cleveland Guardians and the Chicago White Sox meet Wednesday in MLB action from Rate Field. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Cleveland Guardians vs. Chicago White Sox prediction.

Starting Pitching Matchup

The Cleveland Guardians will send out Tanner Bibee for the start and Bibee is 2-8 with a 4.03 ERA and 78 strikeouts this season. Erick Fedde will start for the White Sox and is 2-6 with a 4.46 ERA and 48 strikeouts this season.

Cleveland Guardians Recap

The Cleveland Guardians come into this game looking to rebound from a 2-1 loss at the hands of the White Sox last time out to sit at 41-39 this season. After this series, the Guardians will head home for a series against the Seattle Mariners.

Guardians Lose 6 Of Last 8

Entering Tuesday, Chase DeLauter has 63 hits with 12 doubles, 7 home runs and 34 RBIs while Steven Kwan has 50 hits with 8 doubles, a home run and 13 RBIs and Jose Ramirez has 64 hits with 18 doubles, 10 home runs and 33 RBIs this season. Brayan Rocchio has also added 69 hits with 12 doubles, 5 home runs and 33 RBIs this season while Angel Martinez has 54 hits with 11 doubles, 11 homers and 33 RBIs and Rhys Hoskins has added 32 hits with 12 doubles, 7 home runs and 27 RBIs. Daniel Schneemann has 43 hits with 9 doubles, 6 home runs and 26 RBIs this season.

Chicago White Sox Recap

The Chicago White Sox come into this game looking to add on to their win over Cleveland from Tuesday to improve to 41-37 on the year. After this series, the White Sox will take on the Kansas City Royals in a series at home.

White Sox Pick Up Back-To-Back Wins

Going into Tuesday’s game, Munetaka Murakami has 48 hits with 20 home runs and 41 RBIs while Miguel Vargas has 65 hits with 12 doubles, a triple, 16 home runs and 44 RBIs and Colson Montgomery has 59 hits with 13 doubles, 20 home runs and 45 RBIs. Luisangel Acuna has 28 hits and Tristan Peters has 56 hits with 17 doubles so far this season. Chase Meidroth also has 76 hits with 14 doubles, 6 home runs and 25 RBIs this year.

Cleveland Guardians @ the Chicago White Sox Betting Trends: June 24, 2026

• Probable Starting Pitcher: Erick Fedde      Record this season: 2-6      ERA: 4.46
• Home Record: 1-1
• Last 5 against Guardians: 2-0

Why the Chicago White Sox will win

• The Guardians have lost each of their last seven games as favorites after playing the previous day.
• The White Sox have won each of their last 10 day games against American League opponents following a home win.
• The Guardians have failed to cover the run line in each of their last 12 games as favorites.
• The White Sox have covered the run line in 17 of their last 18 games as home underdogs against American League opponents following a home win.
• The Guardians have trailed after 5 innings in four of their last five games against opponents that held a winning record.
• The Guardians have lost the first inning in three of their last four day games against American League opponents.
• The White Sox have led after 3 innings in each of their last four day games against American League opponents that held a winning record.

• Probable Starting Pitcher: Tanner Bibee       Record this season: 2-8      ERA: 4.03
• Road Record: 1-4
• Last 5 against White Sox: 4-0

Why the Cleveland Guardians will win

• The Guardians have won 13 of their last 14 day games against the White Sox following a road loss.
• The White Sox have lost 12 of their last 13 day games against the Guardians at Rate Field following a win.
• The White Sox have failed to cover the run line in 17 of their last 18 day games against the Guardians at Rate Field following a win.
• The Guardians have covered the run line in 11 of their last 12 day games at Rate Field following a loss.
• The White Sox have lost the first inning in four of their last five day games against opponents that held a winning record.
• The White Sox have trailed after 3 innings in four of their last five day games against opponents that held a winning record.
• The White Sox have trailed after 5 innings in four of their last five day games.

Total Runs Facts

• Six of the Guardians’ last seven games against AL Central opponents have gone UNDER the total runs line.
• Four of the last five games between the Guardians and White Sox have gone UNDER the total runs line.
• There has been at least one run scored in the first inning in each of the White Sox’s last eight day games at Rate Field.
• There has been no run scored during the first inning in each of the Guardians’ last six games as favorites against AL Central opponents.

Chicago White Sox Player Prop Facts

• Miguel Vargas has hit a home run in each of the White Sox’s last two day games against AL opponents that held a winning record.
• Erick Fedde has recorded four strikeouts in each of his last three appearances.
• Chase Meidroth has recorded at least one hit in each of his seven previous appearances in day games against AL Central teams that held a winning record.
• Colson Montgomery ranks T6th in the league in Home Runs (20) this season.

Cleveland Guardians Player Prop Facts

• Rhys Hoskins has hit a home run in two of his last three appearances in day games against AL Central teams that held a winning record.
• Tanner Bibee has recorded six or more strikeouts in four of his five previous appearances in day games against teams that held a winning record.
• Steven Kwan has recorded a hit in each of his last nine Wednesday appearances with the Guardians as favorites.
• Tanner Bibee has recorded a win in each of his three previous appearances against the White Sox.

Matchup/League Facts

• The White Sox rank T2nd in the league for home runs this season (108).
• The White Sox rank 26th in the league for hits this season (611).
• The Guardians rank 29th in the league for slugging percentage this season (.369).
• The Guardians rank 28th in the league for runs scored this season (316).

Cleveland Guardians vs. Chicago White Sox Prediction

I’m backing the White Sox here. The White Sox have been finding ways to get it done in this series and now send out Erick Fedde, who isn’t my favorite option in this White Sox rotation, but he’s been far better at home this season. I’ve given Tanner Bibee the benefit of the doubt, but the fact is that the Guardians have only won 25% of his starts this season and continue to burn money with him as a starter. I’ll back Chicago here.