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Giants vs Dodgers Prediction 4/23/26 MLB Picks Today

LA Dodgers (16-8) vs. San Francisco Giants (11-13)
April 23, 2026 3:45 pm EDT
The Line: San Francisco Giants +135 / LA Dodgers -163; Over/Under: 7
(Get latest betting odds)

The Los Angeles Dodgers and the San Francisco Giants meet Thursday in MLB action from Oracle Park. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Giants vs. Dodgers Prediction.

Starting Pitching Matchup

The Los Angeles Dodgers will send out Tyler Glasnow for the start here and Glasnow is 2-0 with a 3.24 ERA and 29 strikeouts this season. In his last five starts against the Giants, Glasnow is 3-1 with a 5.26 ERA and 23 strikeouts. Logan Webb will start for the Giants and is 2-2 with a 5.40 ERA and 27 strikeouts this season. In his last five starts against the Dodgers, Webb is 2-2 with a 6.04 ERA and 24 strikeouts.

Los Angeles Dodgers Recap

The Los Angeles Dodgers come into this game looking to bounce back from their 3-0 loss at the hands of the Giants in Wednesday’s matchup to slip to 16-8 on the year. After this series, the Dodgers will head home for a series against the Chicago Cubs.

Dodgers Lose 4 Of Last 5

Andy Pages has 30 hits with 4 doubles, 5 home runs and 21 RBIs, while Teoscar Hernandez has 20 hits with 4 doubles, 4 home runs and 13 RBIs. Shohei Ohtani has 23 hits with 4 doubles, 5 home runs and 11 RBIs, and Freddie Freeman has 26 hits with 7 doubles, a triple, 3 home runs and 14 RBIs this season. Will Smith and Mookie Betts each have a pair of home runs as well this season. Max Muncy has added 24 hits with 8 home runs and Kyle Tucker has 21 hits with 2 doubles, 3 home runs and 13 RBIs this season.

San Francisco Giants Recap

The San Francisco Giants come into this game looking to add on to their win over the Dodgers from Wednesday to sit at 11-13 this season. After this series, the Giants will take on the Miami Marlins in a series at home.

Giants Win 5 Of Last 6

Luis Arraez has 27 hits with a double, 2 triples and 6 RBIs, while Willy Adames has 23 hits with 10 doubles, 3 home runs and 6 RBIs. Matt Chapman has 28 hits with 4 doubles, a triple, a home run and 12 RBIs, and Harrison Bader has a home run and 3 RBIs, while Jung Hoo Lee has 22 hits with 6 doubles and 9 RBIs. Heliot Ramos has 23 hits with 4 doubles, 2 home runs and 13 RBIs this season. Rafael Devers also has 23 hits with 3 doubles, 2 home runs and 9 RBIs but also has a team-high 30 strikeouts this season.

Why the San Francisco Giants will win

  • The Giants have won each of their last four games as home underdogs.
  • The Dodgers have lost five of their last six games as road favorites after playing the previous day.
  • The Giants have covered the run line in each of their last six games as underdogs against National League opponents.
  • The Dodgers have failed to cover the run line in five of their last six games at Oracle Park against teams that held a losing record.
  • The Dodgers have lost the first inning in three of their last four games at Oracle Park against opponents that held a losing record.
  • The Giants have led after 5 innings in four of their last five home games against NL West opponents.
  • The Giants have led after 3 innings in four of their last five home games against NL West opponents.

Why the Los Angeles Dodgers will win

  • The Dodgers have won each of their last 19 Thursday games against teams that held a losing record.
  • The Giants have lost 10 of their last 11 games against the Dodgers following a win.
  • The Giants have failed to cover the run line in each of their last nine Thursday games against NL West opponents.
  • The Dodgers have covered the run line in 17 of their last 18 Thursday games against teams that held a losing record.
  • The Dodgers have led after 5 innings in five of their last six day games against the Giants.
  • The Dodgers have led after 3 innings in four of their last five day games against NL West opponents.

Total Runs Facts

  • Each of the Giants’ last six games as underdogs against National League opponents has gone UNDER the total runs line.
  • Each of the Dodgers’ last four day games against National League opponents has gone OVER the total runs line.
  • The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the last four day games between the Dodgers and Giants.
  • The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Dodgers’ last four day games against NL West opponents.

San Francisco Giants Player Prop Facts

  • Luis Arraez has recorded at least one hit in each of his last 11 home appearances against NL opponents that held a winning record.
  • Logan Webb has recorded seven or more strikeouts in four of his last five appearances in day games.
  • Logan Webb has recorded a win in three of his last four appearances against NL opponents.
  • Patrick Bailey has hit a home run in four of his last 10 home appearances against NL West opponents.

Los Angeles Dodgers Player Prop Facts

  • Tyler Glasnow has recorded eight or more strikeouts in six of his last eight road appearances against opponents that held a losing record.
  • Tyler Glasnow has recorded a win in four of his last five appearances against NL West opponents.
  • Shohei Ohtani has hit at least one home run in each of his last four Thursday appearances against teams that held a losing record.
  • Freddie Freeman has recorded at least one hit in each of his last 15 road appearances after playing the previous day.

Matchup/League Facts

  • The Giants rank 30th in the league for steals this season (5).
  • The Giants rank 30th in the league for walks this season (46).
  • The Dodgers rank 1st in the league for home runs this season (42).
  • The Dodgers rank 1st in the league for batting average this season (.280).

Giants vs Dodgers Prediction

I’m on the Giants here. It’s hard to envision the Dodgers continuing to struggle offensively while the Giants just continue to find different ways to get the job done. Glasnow’s had issues with the Giants in his career and while Webb’s had his own struggles with the Dodgers, I still think that the value in this game is on the Giants in this one.

Chris Ruffolo's Free Pick: San Francisco Giants +135

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Chris Ruffolo

Chris joined the Sports Chat Place team in August 2016 and has a proven system that combines multiple analytical and situational statistics and trends to give out thousands of winning picks over the last three years with winning records across all of the top leagues, Follow Chris Ruffolo on Twitter @ruffthepickdawg

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