San Francisco Giants vs NY Yankees Prediction 3/27/26 MLB Picks Today
NY Yankees (1-0) vs. San Francisco Giants (0-1)
March 27, 2026 4:35 pm EDT
The Line: San Francisco Giants +113 / NY Yankees -136; Over/Under: 8
(Get latest betting odds)
The New York Yankees and the San Francisco Giants meet Friday in MLB action from Oracle Park. We will look at this from a betting perspective and determine the best bets for this game. Here’s a New York Yankees vs. San Francisco Giants prediction.
Starting Pitching Matchup
The New York Yankees send out Cam Schlittler for the start here and Schlittler was 4-3 with a 2.96 ERA and 84 strikeouts last season. This will be Schlittler’s first career start against the Giants. Robbie Ray will get the nod for the Giants here and was 11-8 with a 3.65 ERA and 186 strikeouts last season. In his last five starts against the Yankees, Ray is 1-3 with a 4.97 ERA and 26 strikeouts.
New York Yankees Recap
The New York Yankees come into this game looking to add on to their 7-0 win over the Giants from opening day to start the year at 1-0. After this series, the Yankees will head on the road for a series against the Seattle Mariners.
Yankees Looking To Open With Series Win
Trent Grisham went 1 for 5 with a triple and two RBIs while Ryan McMahon added two RBIs as well. Giancarlo Stanton added a 2 for 4 day with an RBI and Jose Caballero chipped in an RBI as well while Austin Wels had a 2 for 3 day at the dish. Jazz Chisholm Jr., Ben Rice and Cody Bellinger each had a base hit as well in the winning effort. Max Fried got the win on the mound after throwing 6.1 innings of two-hit shutout baseball with 4 strikeouts.
Why the New York Yankees will win
- The Yankees have won each of their last eight games against teams that held a losing record.
- The Giants have lost 12 of their last 13 Friday games against AL East opponents that held a winning record.
- The Giants have failed to cover the run line in 12 of their last 13 home games against American League opponents that held a winning record.
- The Yankees have covered the run line in each of their last six games against National League opponents.
New York Yankees Player Prop Facts
- Giancarlo Stanton has hit at least one home run in each of his last five Friday appearances against NL West teams that held a losing record.
- Paul Goldschmidt has recorded at least one Double in each of his last three appearances against NL opponents.
- Giancarlo Stanton has recorded at least one hit in each of his last 12 appearances against the Giants.
- Jose Caballero ranked 1st in the league in Steals (49) last season.
San Francisco Giants Recap
The San Francisco Giants come into this game looking to bounce back from their loss at the hands of the Yankees in the opener. After this series, the Giants will head on the road for a game against the San Diego Padres.
Giants Looking To Split First Two Games
Luis Arraez, Rafael Devers and Heliot Ramos each had a base knock for the Giants as San Francisco only had three hits and none of those hits went for extra bases, while the rest of the Giants’ lineup went 0 for 20 with 4 strikeouts. Logan Webb ended up with the loss, falling to 0-1 on the year after allowing 7 runs, 6 earned, on 9 hits with 7 strikeouts over five innings of work.
Why the San Francisco Giants will win
- The Giants have won each of their last six day games against American League opponents following a home loss.
- The Yankees have lost six of their last eight games as favorites against NL West opponents following a win.
- The Yankees have failed to cover the run line in each of their last 10 games against NL West opponents following a win.
- The Giants have covered the run line in 10 of their last 12 games as underdogs against American League opponents following a loss.
San Francisco Giants Player Prop Facts
- Rafael Devers has recorded a hit in each of the Giants’ last nine games.
- Casey Schmitt has hit a home run in three of the Giants’ last five home games against AL East opponents that held a winning record.
- Luis Arraez ranked T2nd in the league in Hits (181) last season.
Total Runs Facts
- Each of the Giants’ last six day games against AL East opponents have gone OVER the total runs line.
- Eight of the Yankees’ last nine day games against NL West opponents have gone OVER the total runs line.
New York Yankees vs. San Francisco Giants Prediction
I’m on the over here. I expect the Giants to perform better after a sluggish start to the season, but they were facing Max Fried, a strong lefty, and the Giants were the worst team in baseball against lefties last season so I expect some positive regression here against Schlittler in game two. On the other side, the Yankees still scored 7 runs on 10 hits with Aaron Judge doing nothing in the opener, and now face Robbie Ray, a pitcher who has had issues against the Yankees for the better part of his career. Give me the over here.