Seattle Mariners vs Chicago White Sox Prediction 5/18/26 MLB Picks Today

The Chicago White Sox and the Seattle Mariners meet Monday in MLB action from T-Mobile Park. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Chicago White Sox vs. Seattle Mariners prediction.

Starting Pitching Matchup

The Chicago White Sox will send out Noah Schultz for the start here and Schultz is 2-2 with a 4.91 ERA and 26 strikeouts this season. This will be Schultz’s first career start against the Mariners. Bryan Woo will start here for the Mariners and is 3-2 with a 3.91 ERA and 47 strikeouts this season. In his career, Woo is 1-0 with a 1.74 ERA and 24 strikeouts against the White Sox.

Chicago White Sox Recap

The Chicago White Sox come into this game looking to add on to their 9-8 win over the Cubs last time out to sit at 24-22 this season. After this series, the White Sox will head on the road for a series against the San Francisco Giants.

White Sox Win 7 Of Last 8

Munetaka Murakami has 38 hits with 17 home runs and 32 RBIs while Miguel Vargas has 40 hits with 7 doubles, a triple, 11 home runs and 29 RBIs and Colson Montgomery has 39 hits with 8 doubles, 13 home runs and 31 RBIs. Luisangel Acuna has 15 hits and Tristan Peters has 27 hits with 4 doubles so far this season. Chase Meidroth also has 43 hits with 9 doubles, 3 home runs and 10 RBIs this year.

Seattle Mariners Recap

The Seattle Mariners come into this game looking to bounce back from an 8-3 loss at the hands of the San Diego Padres last time out to sit at 22-26 this season. After this series, the Mariners will head on the road for a series against the Kansas City Royals.

Mariners Lose 3 In A Row

Luke Raley has 10 home runs and 27 RBIs this season. Cole Young’s added 42 hits with 8 doubles, a triple, 3 home runs and 26 RBIs and Cal Raleigh has 26 hits with 4 doubles, 7 home runs and 18 RBIs as well this season. Randy Arozarena has 52 hits with 11 doubles, 4 home runs and 18 RBIs as well on the year. Josh Naylor also has 44 hits with 5 home runs and 20 RBIs as well on the year. Julio Rodriguez has also added 48 hits with 9 doubles, 7 home runs and 20 RBIs.

The Chicago White Sox @ Seattle Mariners Betting Trends: May 18, 2026

• Probable Starting Pitcher: Bryan Woo      Record this season: 3-2      ERA: 3.91
• Home Record: 2-0
• Last 5 against White Sox: 1-0

Why the Seattle Mariners will win

• The Mariners have won each of their last six games against the White Sox following a home loss.
• The White Sox have lost seven of their last eight games at T-Mobile Park.
• The Mariners have covered the run line each of their last four home games against AL Central opponents that held a winning record.
• The White Sox have failed to cover the run line in each of their last four games as road underdogs against the Mariners following a win.
• The Mariners have led after 3 innings in four of their last five games against American League opponents.
• The Mariners have led after 5 innings in seven of their last eight games as favorites against American League opponents.

• Probable Starting Pitcher: Noah Schultz      Record this season: 2-2      ERA: 4.91
• Road Record: 2-1
• Last 5 against Mariners: –

Why the Chicago White Sox will win

• The White Sox have won nine of their last 10 games as underdogs against American League opponents.
• The Mariners have lost four of their last five games as favorites.
• The White Sox have covered the run line in each of their last nine games against American League opponents following a home win.
• The Mariners have failed to cover the run line each of their last seven night games against teams that held a winning record.
• The Mariners have lost the first inning in four of their last five night games against American League opponents that held a winning record.
• The White Sox have led after 3 innings in each of their last four games as road underdogs against American League opponents.
• The White Sox have led after 5 innings in each of their last four games as road underdogs against American League opponents.

Total Runs Facts

• Each of the White Sox’s last six games have gone OVER the total runs line.
• Five of the Mariners’ last six night games after playing the previous day have gone UNDER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Mariners’ last 13 games as home favorites against American League opponents.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in nine of the White Sox’s last 10 games as underdogs.

Seattle Mariners Player Prop Facts

• Julio Rodriguez has recorded at least one hit in each of the Mariners’ last 13 home games against AL opponents.
• Cal Raleigh has hit a home run in three of his last four home appearances against AL opponents.
• Randy Arozarena ranks T8th in the league in Steals (12) this season.

Chicago White Sox Player Prop Facts

• Miguel Vargas has hit a home run in each of the White Sox’s last two games as road underdogs against AL opponents.
• Miguel Vargas has recorded at least one hit in each of the White Sox’s last 19 games as underdogs.
• Munetaka Murakami ranks 2nd in the league in Home Runs (17) this season.

Matchup/League Facts

• The Mariners rank 1st in the league for walks allowed this season (122).
• The Mariners rank 27th in the league for doubles this season (62).
• The White Sox rank 30th in the league for doubles this season (56).
• The White Sox rank T2nd in the league for home runs this season (66).

Chicago White Sox vs. Seattle Mariners Prediction

I’m on the Mariners in this one. There’s no denying that the White Sox have been the hotter team, but it still looks like Schultz has had some issues adjusting to the Major League level, and the Mariners just have a significant edge in starting pitching with Woo going here and bouncing back from a couple of rough starts at the end of April/early May. I think the Mariners take the opener here so give me Seattle.