Mariners vs Padres Prediction 8/25/25 MLB Picks Today

The San Diego Padres and the Seattle Mariners meet Monday in MLB action from T-Mobile Park. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Mariners vs Padres Prediction.

Starting Pitching Matchup

The San Diego Padres will send out JP Sears for the start here and Sears is 8-10 with a 4.94 ERA and 103 strikeouts this season. In his last five starts against Seattle, Sears is 0-5 with a 4.03 ERA and 30 strikeouts. Bryce Miller will get the nod for the Mariners here and is 2-5 with a 5.87 ERA and 43 strikeouts this season. This will be Miller’s second career start against San Diego.

San Diego Padres Recap

The San Diego Padres come into this game looking to rebound from an 8-2 loss at the hands of the Los Angeles Dodgers on Sunday to drop to 74-57 this season. After this series, the Padres will head on the road for a series against the Minnesota Twins.

Padres Have Five-Game Win Streak Snapped

Manny Machado has 145 hits including a team-high 32 doubles, 21 home runs, 77 RBIs and 12 stolen bases while Fernando Tatis Jr. has 128 hits with 17 home runs and 52 RBIs along with 25 stolen bases of his own this season. Luis Arraez has added 144 hits with 27 doubles, 4 triples, 6 home runs and 47 RBIs while Jackson Merrill’s added 91 hits with 9 home runs and 51 RBIs as well. Xander Bogaerts also has 28 doubles and 19 stolen bases as well this season. Gavin Sheets also has 18 doubles, 17 home runs and 58 RBIs as well this season.

Why the San Diego Padres will win

• The Padres have won each of their last nine games following a home loss.
• The Mariners have lost five of their last six games as favorites after playing the previous day.
• The Mariners have failed to cover the run line in each of their last 10 games as favorites against National League opponents following a win.
• The underdogs have covered the run line in each of the last six games between the Padres and Mariners.

San Diego Padres Player Prop Facts

• Fernando Tatis Jr. has hit a home run in each of the Padres’ last two road games against the Mariners.
• JP Sears has recorded five or more strikeouts in each of his last five appearances with his team as an underdog.
• Xander Bogaerts has recorded at least one hit in each of his last nine road appearances against the Mariners after playing the previous day.
• Xander Bogaerts has recorded at least one Double in each of the Padres’ last three games as underdogs against AL West opponents.
• Manny Machado ranks 4th in the league in Hits (147) this season.

Seattle Mariners Recap

The Seattle Mariners come into this game looking to add on to their 11-4 win over the Athletics last time out to sit at 70-61 this season. After this series, the Mariners will head on the road for a series against the Cleveland Guardians.

Mariners Alternate Wins & Losses In 4 In A Row

Jorge Polanco has 87 hits including 18 home runs and 54 RBIs while Cal Raleigh has 116 hits with 19 doubles, a team-high 47 home runs and 102 RBIs. Randy Arozarena has 114 hits with 25 doubles, 23 home runs, 59 RBIs and 24 stolen bases. Julio Rodriguez also has 138 hits with 24 doubles, 4 triples, 25 home runs, 71 RBIs and 23 stolen bases. Dylan Moore has 9 homers and 12 stolen bases as well this season. J.P Crawford has 122 hits with 19 doubles, 9 home runs and 44 RBIs.

Why the Seattle Mariners will win

• • The Mariners have won nine of their last 10 games at T-Mobile Park.
  • The Padres have lost each of their last five road games against American League opponents.
  • The Mariners have covered the run line in eight of their last nine games against the Padres.
  • The Padres have failed to cover the run line in eight of their last nine night games against American League opponents.

Seattle Mariners Player Prop Facts

• Cal Raleigh has hit a home run in three of the Mariners’ last four games against NL West opponents that held a winning record.
• Bryce Miller has recorded four or more strikeouts in each of his last 11 appearances in night games against NL teams that held a winning record.
• Victor Robles has recorded at least one hit in each of his last 10 appearances.
• Bryce Miller has recorded a win in four of his last five appearances with the Mariners as home favorites against NL opponents.
• J.P. Crawford has recorded a Double in five of his last six home appearances against NL West opponents that held a winning record.
• Cal Raleigh ranks 1st in the league in Home Runs (49) this season.

Total Runs Facts

• Each of the Padres’ last eight night games as underdogs have gone UNDER the total runs line.
• Each of the Mariners’ last four games against National League opponents have gone OVER the total runs line.

Mariners vs Padres Prediction

I’m going to side with the Padres in this one. I get the case to be made for the Mariners at home, but Bryce Miller hasn’t looked very good. Not just in his last start coming back from injury, but in his last few starts spanning the last couple of months. JP Sears hasn’t had a ton of luck against the Mariners in his career, but his ERA isn’t bloated, which tells me at times he doesn’t get a ton of run support. I think that Sears gets the support here behind the Padres, and I think San Diego gets the win here. Give me San Diego.