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Tigers vs Giants Prediction 5/27/25 MLB Picks Today

San Francisco Giants (31-23) vs. Detroit Tigers (35-20)
May 27, 2025 6:40 pm EDT
The Line: Detroit Tigers 102 / San Francisco Giants -122; Over/Under: 7
(Get latest betting odds)

The San Francisco Giants and Detroit Tigers meet Tuesday in MLB action at Comerica Park. Here’s a Tigers vs Giants Prediction. This article will include a Tigers vs Giants Pick.

San Francisco Giants Betting Preview

The San Francisco Giants are 31-23 on the year and play the Marlins, Padres, and Braves next. The San Francisco Giants are batting .231 on the season, have a .308 OBP, and a .376 slugging percentage. The San Francisco Giants’ pitching staff has a 3.25 ERA and a 1.21 WHIP. Jung Hoo Lee leads the San Francisco Giants with 59 hits and 31 RBI, while Heliot Ramos and Wilmer Flores have combined for 105 hits and 71 RBI.

Logan Webb gets the ball for the San Francisco Giants, and he is 5-4 with a 2.67 ERA and 74 strikeouts this season. Webb is 1-1 with a 0.77 ERA and 14 strikeouts in his career against the Detroit Tigers.

Detroit Tigers Betting Preview

The Detroit Tigers are 35-20 on the year and play the Royals, White Sox, and Cubs next. The Detroit Tigers are batting .253 on the season, have a .326 OBP, and a .410 slugging percentage. The Detroit Tigers’ pitching staff has a 3.27 ERA and a 1.16 WHIP. Riley Greene leads the Detroit Tigers with 55 hits and 36 RBI, while Kerry Carpenter and Spencer Torkelson have combined for 97 hits and 62 RBI.

Jack Flaherty gets the ball for the Detroit Tigers, and he is 2-6 with a 4.39 ERA and 64 strikeouts this season. Flaherty is 1-2 with a 5.26 ERA and 25 strikeouts in his career against the San Francisco Giants.

Why the Detroit Tigers will win

  • The Giants have lost each of their last five games as road favorites against AL Central opponents.
  • The Tigers have won each of their last three games as home underdogs against the Giants.
  • The Giants have failed to cover the run line each of their last eight games against American League opponents that held a winning record.
  • The underdogs have covered the run line in 16 of the Giants’ last 18 games.
  • The Tigers have led after 5 innings in six of their last seven home games against National League opponents.
  • The Giants have trailed after 3 innings in five of their last six games as favorites against AL Central opponents.

Why the San Francisco Giants will win

  • The Giants have won each of their last five games following a loss.
  • The Tigers have lost each of their last six Tuesday games against NL West opponents that held a winning record.
  • The Tigers have failed to cover the run line in each of their last seven night games following a win.
  • The Giants have covered the run line in six of their last seven road games against AL Central opponents that held a winning record.
  • The Giants have led after 5 innings in nine of their last 11 night games against American League opponents that held a winning record.
  • The Giants have led after 3 innings in four of their last five road games against AL Central opponents that held a winning record.
  • The Giants have won the first inning in three of their last four night games against the Tigers.

Detroit Tigers Player Prop Facts

  • Riley Greene has hit a home run in two of the Tigers’ last three games as home underdogs.
  • Colt Keith has recorded a Double in four of his last five appearances against opponents that held a winning record.
  • Riley Greene has recorded at least one RBI in each of the Tigers’ last four games as home underdogs.
  • Zach McKinstry has scored at least one run in seven of his last eight appearances against NL West opponents.
  • Riley Greene has recorded at least one Single in eight of the Tigers’ last nine home games against NL West opponents.
  • Jack Flaherty has recorded six or more strikeouts in each of his last five home appearances against opponents that held a winning record.
  • Parker Meadows has recorded at least one hit in each of his last 13 appearances in night games.

San Francisco Giants Player Prop Facts

  • Jung Hoo Lee has recorded at least one RBI in four of the Giants’ last five night games against opponents that held a winning record.
  • Heliot Ramos has recorded at least one Single in each of his last 11 appearances against AL opponents.
  • Logan Webb has recorded six or more strikeouts in each of his last four appearances with the Giants as road favorites against AL opponents.
  • Jung Hoo Lee has recorded at least one hit in each of the Giants’ last 12 games against AL opponents that held a winning record.
  • Tom Murphy has recorded a Double in four of his last five road appearances against AL Central opponents.
  • Tom Murphy has hit a home run in each of his last two appearances in night games against AL Central teams that held a winning record.
  • Tom Murphy has scored a run in each of his last four appearances against AL Central opponents.
  • Logan Webb ranks 9th in the league for total Strikeouts (74) this season.

Tigers vs Giants Prediction

The Giants are going to be favored with Webb on the mound, but he’s never been the same pitcher on the road that he is at home. Even this season, Webb has a 3.86 ERA on the road compared to a 1.39 ERA at home. Flaherty has been a disappointment since coming over from the Dodgers, but you’d assume he’ll get his act together at some point. Flaherty has allowed three or fewer earned runs in seven of his 10 starts, so he’s shown flashes here and there. Throw out the pitching matchup; the Tigers are one of the best teams in baseball, so getting them at the more favorable price has value. Give me the Tigers on Tuesday.

Randy Chambers's Free Pick: Detroit Tigers +102

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Randy Chambers

Randy has covered sports betting since 2014 and writes about everything from NFL to WNBA. Follow Randy Chambers on Twitter.

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