Tigers vs Guardians Prediction 5/23/25 MLB Picks Today

In this article we will formulate a Tigers vs Guardians prediction for this MLB game on Friday, May 23rd at Comerica Park in Detroit, Michigan. Let’s take a look at the prediction for this MLB matchup. 

Detroit Tigers Betting Preview

The Detroit Tigers are 33-18 this season after they lost game one in this series by a score of 7-0. Detroit fell behind in the fourth inning and their offense never got started, then the bullpen had some issues in the ninth for the blowout loss. The Tigers recorded five hits and they committed one error in the game, while they were led by Baez, who went 2-3 in the loss. Detroit started Flaherty, who allowed three hits and three earned runs over 6.2 innings for the loss, while Guenther and Brebbia allowed three earned runs in relief. 

Prior to this series, the Tigers won two out of three against the Cardinals and two out of three against the Blue Jays. Detroit has won three of their last five games and they are currently first in the AL Central standings. The Detroit pitching staff has a 3.36 ERA with a 1.17 WHIP and a .227 opponent batting average, while the offense has scored 267 runs with a .257 batting average and a .328 on base percentage this season. Spencer Torkelson has led Detroit with 12 home runs and 39 RBIs, while Riley Greene has added 12 home runs and 34 RBIs this year. The projected starting pitcher for Detroit is Jackson Jobe, who is 4-0 with a 4.12 ERA and a 1.45 WHIP over 39.1 innings pitched this season. 

Cleveland Guardians Betting Preview

The Cleveland Guardians are 27-22 this year after they won game one by a score of 7-0 on Thursday night. Cleveland scored two runs in the fourth inning to take the lead and they never looked back in the easy win. The Guardians recorded six hits in the game and they were led by Martinez, who went 2-4 with one home run and three RBIs in the win. Cleveland started Bibee, who allowed three hits and zero earned runs over 7.0 innings for the win, while Smith picked up a hold in relief. 

Prior to this series, the Guardians split two games with the Twins and lost all three against the Reds. Cleveland has lost five of their last seven games and they are currently second in the AL Central standings. The Cleveland pitching staff has a 4.03 ERA with a 1.40 WHIP and a .257 opponent batting average, while the offense has scored 199 runs with a .233 batting average and a .306 on base percentage this season. Kyle Manzardo has led Cleveland with 10 home runs and 26 RBIs, while Jose Ramirez has added nine home runs and 24 RBIs this year. The projected starting pitcher for Cleveland is Slade Cecconi, who is 0-1 with a 5.40 ERA and a 1.00 WHIP over 5.0 innings pitched this year. 

Why the Tigers will beat the Guardians

• The Tigers have won seven of their last eight night games following a loss.
• The Guardians have lost three of their last four games after playing the previous day.
• The Tigers have covered the run line in 12 of their last 13 night games against AL Central opponents.
• The Guardians have failed to cover the run line in four of their last five road games against American League opponents following a win.
• The Guardians have trailed after 5 innings in six of their last seven games as road underdogs against American League opponents.
• The Guardians have trailed after 3 innings in six of their last seven games as road underdogs against American League opponents.
• The Tigers have won the first inning in four of their last five games as favorites against the Guardians at Comerica Park.

Total Runs Facts

• Eight of the Guardians’ last nine night games after playing the previous day have gone UNDER the total runs line.
• Six of the Tigers’ last seven night games after playing the previous day have gone OVER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in 11 of the Guardians’ last 12 night games.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Tigers’ last four games as favorites against AL Central opponents.

Detroit Tigers Player Prop Facts

• Riley Greene has hit a home run in three of the Tigers’ last five games as favorites.
• Kerry Carpenter has recorded at least one RBI in four of his five previous appearances with the Tigers as favorites against the Guardians.
• Kerry Carpenter has recorded at least one Single in each of the Tigers’ last seven games against AL Central opponents.
• Matt Vierling has recorded at least one Double in four of his last five appearances with the Tigers as favorites against the Guardians.
• Parker Meadows has recorded at least one hit in each of his last 13 appearances in night games.
• Matt Vierling has scored at least one run in each of his last six appearances with the Tigers as home favorites against AL Central opponents.
• Riley Greene ranks T9th in the league in Home Runs (12) this season.

Cleveland Guardians Player Prop Facts

• Jose Ramirez has hit at least one home run in three of the Guardians’ last five road games against the Tigers.
• Carlos Santana has recorded at least one RBI in seven of the Guardians’ last eight road games.
• Jose Ramirez has scored a run in each of the Guardians’ last five games against AL Central opponents.
• Steven Kwan has recorded at least one Single in each of the Guardians’ last 10 road games against AL opponents that held a winning record.
• Jose Ramirez has recorded at least one hit in each of the Guardians’ last 15 games.
• Steven Kwan ranks T4th in the league in Hits (60) this season.

Matchup/League Facts

• The Tigers rank 30th in the league for steals this season (20).
• The Tigers rank 4th in the league for runs scored this season (267).
• The Guardians rank 26th in the league for hits this season (365).
• The Guardians rank 5th in the league for strikeouts against this season (374).

Tigers vs Guardians Prediction 

Cleveland comes into this contest after a big victory in game one on Thursday night and they are looking for their third straight win. The Guardians are 13-14 on the road this season, while the Tigers are 17-6 at home. Detroit has been the best team in the MLB to start the season and they don’t lose back to back games very often. The Tigers are starting Jobe, who has allowed two earned runs or fewer in three of his last five starts. The Guardians are going with Cecconi, who allowed five hits and three earned runs against Cincinnati in his first outing. Detroit has been excellent after a loss this season and they are 8-0 in games that Jobe has pitched. Take the Tigers here.