Tigers vs Guardians Prediction 9/17/25 MLB Picks Today

In this article we will formulate a Tigers vs Guardians prediction for this MLB game on Wednesday, September 17th at Comerica Park in Detroit, Michigan. Let’s take a look at the prediction for this MLB matchup. 

Detroit Tigers Betting Preview

The Detroit Tigers are 85-66 this year after they lost game one by a score of 7-5 in extra innings on Tuesday night. Detroit tied the game at three in the ninth inning, but allowed four runs in the 10th for the loss. The Tigers recorded nine hits in the game and they were led by Torkelson, who went 4-5 with one home run and two RBIs in the loss. Detroit started Mize, who allowed seven hits and three earned runs over 5.1 innings, while Vest was charged with the loss. 

Prior to this series, the Tigers lost two out of three against the Marlins, but did win two out of three against the Yankees before that. Detroit has lost four of their last five games and they are currently first in the AL Central standings. The Detroit pitching staff has a 3.92 ERA with a 1.24 WHIP and a .241 opponent batting average, while the offense has scored 734 runs with a .249 batting average and a .318 on base percentage this season. Riley Greene has led Detroit with 34 home runs and 108 RBIs, while Spencer Torkelson has added 29 home runs and 74 RBIs this year. The projected starting pitcher for Detroit is Jack Flaherty, who is 8-13 with a 4.69 ERA and a 1.28 WHIP over 151.2 innings pitched this year. 

Cleveland Guardians Betting Preview

The Cleveland Guardians are 79-71 this season after they won game one by a score of 7-5 on Tuesday. Cleveland led 1-0 and 3-1, but they needed four runs in the 10th to escape with the victory. The Guardians recorded 13 hits and they committed one error in the game, while they were led by Arias, who went 2-5 with one home run and two RBIs in the win. Cleveland started Cantillo, who allowed four hits and one earned run over 5.0 innings, while Smith blew the save, but did get the win. 

Prior to this series, the Guardians won all three against the White Sox and three out of four against the Royals. Cleveland has won five games in a row and they are second in the AL Central standings. The Cleveland pitching staff has a 3.79 ERA with a 1.29 WHIP and a .242 opponent batting average, while the offense has scored 587 runs with a .226 batting average and a .296 on base percentage this season. Jose Ramirez has led Cleveland with 28 home runs and 78 RBIs, while Kyle Manzardo has added 26 home runs and 67 RBIs this year. The projected starting pitcher for Cleveland is Logan Allen, who is 7-11 with a 4.43 ERA and a 1.44 WHIP over 144.1 innings pitched this season. 

Why the Tigers will beat the Guardians

• The Tigers have won each of their last eight home games after going to extra innings.
• The Guardians have lost nine of their last 12 road games following an extra innings win.
• The Tigers have covered the run line in each of their last four games against American League opponents following a loss.
• The Guardians have failed to cover the run line in each of their last six Wednesday games at Comerica Park.
• The Tigers have led after 3 innings in each of their last five Wednesday games against AL Central opponents that held a winning record.
• The Tigers have led after 5 innings in each of their last eight Wednesday games against opponents that held a winning record.

Total Runs Facts

• Each of the Guardians’ last six games after playing the previous day have gone UNDER the total runs line.
• Seven of the Tigers’ last eight games have gone OVER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Guardians’ last four road games.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in four of the last five games between the Guardians and Tigers.

Detroit Tigers Player Prop Facts

• Jack Flaherty has recorded six or more strikeouts in 11 of his last 12 home appearances against opponents that held a winning record.
• Spencer Torkelson has hit a home run in each of the Tigers’ last three home games against AL Central opponents that held a winning record.
• Jake Rogers has recorded a Double in three of his last four appearances against AL Central opponents.
• Gleyber Torres has recorded at least one hit in each of his last nine appearances against AL opponents that held a winning record.

Cleveland Guardians Player Prop Facts

• Austin Hedges has hit a home run in two of his last three road appearances against opponents that held a winning record.
• Jose Ramirez has recorded a Double in four of the Guardians’ last five games as underdogs.
• Steven Kwan has recorded at least one hit in each of his last 12 appearances with the Guardians as road underdogs against AL Central opponents.

Tigers vs Guardians Prediction 

Cleveland picked up a huge win to start this series on Monday, but they need to win the next two if they want a chance at the division. The Guardians are 38-37 on the road this year, while the Tigers are 46-30 at home. Detroit is allowing a bunch of runs right now and they are starting Flaherty, who has allowed 0, 4, 1, and 8 earned runs in his last four starts. Cleveland is going with Allen, who has allowed 1, 3, 4, and 9 earned runs in his last four outings. We have seen Flaherty step up in big spots for Detroit all season and I think he will do it again here. Take the Tigers to win.