Twins vs Astros Prediction 5/20/26 MLB Picks Today

In this article we will formulate a Twins vs Astros prediction for this MLB game on Wednesday, May 20th at Target Field in Minneapolis, Minnesota. Let’s take a look at the prediction for this MLB matchup. 

Minnesota Twins Betting Preview

The Minnesota Twins are 22-27 this year after they split the first two games in this series by scores of 6-3 and 1-2. In game two, Minnesota cut the deficit to 2-1 in the eighth inning, but couldn’t get any closer in the loss. The Twins recorded eight hits in the game and they were led by Bell, who went 3-4 with one RBI. Matthews allowed five hits and two earned runs over 6.0 innings for the loss, while Adams threw two scoreless innings in relief. Prior to this series, Minnesota lost two out of three against the Brewers, but did win two out of three against the Marlins before that. 

This season, Minnesota has a 4.27 ERA with a 1.33 WHIP and a .244 opponent batting average, while they have scored 226 runs with a .236 batting average and a .323 on base percentage. Byron Buxton has led the Twins with 15 home runs and 23 RBIs, while Josh Bell has added five home runs and 29 RBIs. The projected starting pitcher for Minnesota is Joe Ryan, who is 2-3 with a 3.20 ERA and a 1.01 WHIP over 50.2 innings pitched this year. 

Houston Astros Betting Preview

The Houston Astros are 20-30 this season after they won game two by a score of 2-1 last night. Houston scored both of their runs in the first inning, which was enough to get the low scoring win. The Astros recorded five hits in the game and they were led by Paredes, who went 1-4 with one home run and two RBIs. Alexander allowed four hits and zero earned runs over 6.0 innings for the win, while Abreu picked up the save. Prior to this series, Houston won two out of three against the Rangers, but lost three out of four against the Mariners before that. 

This season, Houston has a 5.36 ERA with a 1.54 WHIP and a .256 opponent batting average, while they have scored 217 runs with a .248 batting average and a .324 on base percentage. Yordan Alvarez has led the Astros with 15 home runs and 31 RBIs, while Christian Walker has added 11 home runs and 31 RBIs. The projected starting pitcher for Houston is Mike Burrows, who is 2-5 with a 5.72 ERA and a 1.53 WHIP over 50.1 innings pitched this season. 

Why the Minnesota Twins will win

• The Astros have lost seven of their last eight games following a road win.
• The home team has won four of the last five games between the Astros and Twins.
• The Astros have failed to cover the run line in seven of their last eight games following a road win.
• The Twins have covered the run line in each of their last four games following a loss.
• The Twins have led after 5 innings in each of their last seven home day games.
• The Twins have won the first inning in six of their last eight day games at Target Field.
• The Twins have led after 3 innings in each of their last four home day games.

Why the Houston Astros will win

• The Twins have lost 14 of their last 16 games as favorites after playing the previous day.
• The Astros have won each of their last six Wednesday games as underdogs against American League opponents.
• The Twins have failed to cover the run line in 14 of their last 16 games as favorites after playing the previous day.
• The Astros have covered the run line in each of their last six Wednesday games as underdogs against American League opponents.
• The Twins have trailed after 3 innings in each of their last five day games against AL West opponents that held a losing record.
• The Astros have led after 5 innings in four of their last five games against AL Central opponents.

Total Runs Facts

• Each of the Twins’ last four day games after playing the previous day have gone OVER the total runs line.
• Four of the Astros’ last five road games after playing the previous day have gone UNDER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Astros’ last eight Wednesday day games.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in 11 of the Twins’ last 12 home games against AL West opponents.

Minnesota Twins Player Prop Facts

• Byron Buxton has hit at least one home run in four of his last five home appearances after playing the previous day.
• Joe Ryan has recorded a win in three of his last four appearances in day games against teams that held a losing record.
• Byron Buxton has recorded at least one hit in each of his last 11 Wednesday day appearances with the Twins as favorites.
• Byron Buxton ranks T5th in the league in Home Runs (15) this season.

Houston Astros Player Prop Facts

• Isaac Paredes has hit a home run in two of his last three appearances after playing the previous day.
• Isaac Paredes has recorded at least one hit in each of his last eight road appearances against AL Central opponents that held a losing record.
• Yordan Alvarez ranks 3rd amongst qualified players for On Base Percentage (.419) this season.

Matchup/League Facts

• The Twins rank 27th in the league for strikeouts this season (367).
• The Twins rank 24th in the league for runs allowed this season (230).
• The Astros rank 30th in the league for ERA this season (5.36).
• The Astros rank 30th in the league for walks allowed this season (246).

Twins vs Astros Prediction 

Minnesota comes into this matchup after winning two of their last three games, but they have scored two runs or fewer in three of their last five. The Twins are 14-14 at home this year, while the Astros are 8-16 on the road. Houston has won three of their last five games, but they have allowed 6+ runs in two of their last three. The Astros are starting Burrows, who has allowed 3+ earned runs in three of his last five starts, while Ryan has allowed two earned runs or fewer in three straight starts. Take the Twins once again here.