Twins vs Giants Prediction 5/10/25 MLB Picks Today

The San Francisco Giants and the Minnesota Twins meet Saturday in MLB action from Target Field. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Twins vs Giants Prediction.

Starting Pitching Matchup

The San Francisco Giants will send out Logan Webb and Webb is 4-2 with a 2.61 ERA and 56 strikeouts this season. This will be Webb’s first career start against the Twins. Joe Ryan will get the start for the Twins here and is 2-2 with a 2.93 ERA and 47 strikeouts this season. In his career, Ryan is 2-1 with a 3.31 ERA and 18 strikeouts against San Francisco.

San Francisco Giants Recap

The San Francisco Giants come into this game looking to bounce back from a 3-1 loss at the hands of the Twins in Friday’s matchup to fall to 24-15 on the year. After this series, the Giants will head home for a division series against the Arizona Diamondbacks.

Giants Win 5 Of Their Last 7

Jung Hoo Lee leads the Giants with 43 hits including a team-high 11 doubles along with a pair of triples, 4 home runs and 23 RBIs with 3 stolen bases while Heliot Ramos has 36 hits with 9 doubles, 5 home runs and 14 RBIs. Wilmer Flores also has a team-high 7 home runs and 33 RBIs while Mike Yastrzemski has 5 home runs with 17 RBIs and 7 doubles and Tyler Fitzgerald has a team-high 5 stolen bases as well on the year.

Why the San Francisco Giants will win

• The Giants have won each of their last four games as underdogs against AL Central opponents.
• The Twins have lost six of their last seven games as home favorites against National League opponents following a win.
• The Giants have covered the run line in each of their last seven games as underdogs against AL Central opponents.
• The Twins have failed to cover the run line in each of their last seven games as home favorites against National League opponents following a home win.

San Francisco Giants Player Prop Facts

• Matt Chapman has hit a home run in three of the Giants’ last four games against opponents that held a losing record.
• Logan Webb has recorded a win in three of his last four appearances with the Giants as road underdogs.
• Matt Chapman has scored at least one run in each of the Giants’ last seven games.
• Heliot Ramos has recorded a Single in seven of the Giants’ last eight night games against AL opponents that held a losing record.
• Heliot Ramos has recorded at least one hit in each of the Giants’ last nine games against AL opponents that held a losing record.
• Logan Webb has recorded six or more strikeouts in each of his last five appearances in night games.
• Tom Murphy has recorded a Double in four of his last five road appearances against AL Central opponents.
• Tom Murphy has recorded an RBI in four of his last five appearances against the Twins.
• Logan Webb ranks T8th in the league for total Strikeouts (56) this season.

Minnesota Twins Recap

The Minnesota Twins will be out to build on their 3-1 win over the Giants from Friday’s matchup to improve to 19-20 on the year. After this series, the Twins will head on the road for a rematch series against the Baltimore Orioles.

Twins Win Six In A Row

Byron Buxton has 37 hits along with 5 doubles, a team-high 9 home runs and 25 RBIs with 8 stolen bases and a pair of triples while Carlos Correa has 30 hits with 8 doubles and Willi Castro has 17 hits with 6 doubles as well. Harrison Bader’s added 4 home runs and 16 RBIs while Buxton’s contributed a team-high 47 strikeouts as well this season. Ty France has also added 38 hits, 8 doubles, 3 home runs and 21 RBIs and Trevor Larnach’s chipped in 5 home runs and 17 RBIs as well this season.

Why the Minnesota Twins will win

• The Twins have won each of their last 10 Saturday games against NL West opponents.
• The Giants have lost each of their last six road games against AL Central opponents that held a losing record.
• The Twins have covered the run line in each of their last nine games following a win.
• The Giants have failed to cover the run line each of their last six road games against AL Central opponents that held a losing record.

Minnesota Twins Player Prop Facts

• Byron Buxton has hit a home run in three of the Twins’ last five games.
• Willi Castro has recorded a Double in four of the Twins’ last five games as favorites against NL opponents.
• Joe Ryan has recorded a win in each of his three previous home appearances against NL West opponents.
• Byron Buxton has recorded at least one RBI in five of his last six appearances with the Twins as favorites against NL West opponents.
• Byron Buxton has scored at least one run in each of his last six home appearances.
• Joe Ryan has recorded seven or more strikeouts in four of his last five appearances in night games.
• Harrison Bader has recorded at least one hit in each of his last nine appearances against opponents that held a winning record.
• Carlos Correa has recorded at least one Single in each of his nine previous home appearances against the Giants after playing the previous day.

Total Runs Facts

• Each of the Giants’ last eight night games as underdogs have gone OVER the total runs line.
• Each of the Twins’ last seven games as favorites against NL West opponents have gone OVER the total runs line.

Twins vs Giants Prediction

I’m on the Twins here. I get the case to be made for the Giants here as San Francisco has still been one of the better road teams in baseball up to this point in the year. However, the Twins are rolling right now and have almost dug themselves out of the deep hole that they had to start the year and are playing really well at this point of the run. What’s impressed me is that they just find different ways to win and I think they do the same here in another low-scoring battle against the Giants once again. Give me Minnesota here.