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Twins vs Mariners Prediction 6/25/25 MLB Picks Today

Seattle Mariners (41-37) vs. Minnesota Twins (37-42)
June 25, 2025 7:40 pm EDT
The Line: Minnesota Twins -131 / Seattle Mariners 107; Over/Under: 8
(Get latest betting odds)

In this article, we will formulate a Twins vs Mariners prediction for this MLB game on Wednesday, June 25, at Target Field in Minneapolis, Minnesota. Let’s take a look at the prediction for this MLB matchup.

Seattle Mariners Betting Preview

The Seattle Mariners (41-37, 21-18 Away) have swept the Cleveland Guardians, lost to the Boston Red Sox, and beat the Chicago Cubs in the previous three series. Seattle will at least split the current series in Minneapolis after winning the opening two games against the Twins. In Tuesday’s 6-5 victory, Donovan Solano and Julio Rodriguez led the offense with two RBI apiece, while Luis Castillo pitched for 5.0 innings in a no-decision, allowing five runs on seven hits with three strikeouts and two walks. Andres Munoz was credited with the win.

This season, the Mariners average 4.65 runs per game (10th in the MLB) on a .249/.326/.411 triple-slash. When it comes to pitching, the Mariners’ staff has a 3.96 ERA (18th) and 1.28 WHIP (18th). Cal Raleigh leads the Mariners with a .281 batting average, 32 home runs, and 69 RBI this season.

George Kirby will take the mound for the Mariners on Wednesday. The 27-year-old right-hander has a 1-3 record in six starts this year with a 6.16 ERA and 1.40 WHIP in 30.2 innings.

Minnesota Twins Betting Preview

The Minnesota Twins (37-42, 20-17 Home) lost 11 of their previous 12 games. The Twins are on a five-game losing skid after being swept by the Milwaukee Brewers and after losing the first two games of the series against the Mariners. In Tuesday’s 6-5 defeat, Ryan Jeffers led the offense with two RBI, while Chris Paddack pitched for 5.0 innings in a no-decision, allowing five runs (four earned) on five hits with four strikeouts and one walk. Jhoan Duran took the loss.

This year, the Twins average 4.23 runs per game (20th in the MLB) on a .243/.314/.396 triple-slash. When it comes to pitching, the Twins’ staff has a 4.26 ERA (23rd) and 1.26 WHIP (15th). Byron Buxton leads the Twins with a .280 batting average, 17 home runs, and 47 RBI this season.

The projected starting pitcher for the Twins is Joe Ryan, who is 7-3 in 14 starts this season, with a 3.06 ERA and 0.91 WHIP in 85.1 innings.

Total Runs Facts

  • Seven of the Mariners’ last eight road games have gone OVER the total runs line.
  • Seven of the Twins’ last eight home games against American League opponents have gone OVER the total runs line.
  • The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the last four games between the Mariners and Twins.
  • The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Mariners’ last four games against American League opponents.

Matchup/League Facts

  • The Twins are one of only three teams in the league to rank top 10 in both strikeouts and walks allowed this season.
  • The Twins rank 22nd in the league for walks this season (234).
  • The Mariners are one of only three teams in the league to rank top 10 in both steals and home runs this season.
  • The Mariners rank 4th in the league for steals this season (77).

Twins vs Mariners Prediction

The teams have traded wins in the past couple of years, each recording five in the previous ten H2H encounters. This season, Seattle won four out of five duels. I am leaning toward the Twins in this one, because of Joe Ryan, but I’ll opt for Over instead, as seven of the last ten H2Hs went Over, while that was the case in seven of Seattle’s previous ten games. Also, Ryan allowed multiple runs in each of his last four starts, while Kirby surrendered multiple runs in all his starts this season. Expect to see runs on each side early on and back the Over.

Oliver Zivic's Free Pick: Over 7.5

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Oliver Zivic

Professional journalist and expert bettor with 20+ years of experience. I cover Football (soccer), NFL, NBA, NHL, MLB, CFB, and CBB.

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