White Sox vs Astros Prediction 6/12/25 MLB Picks Today

The Chicago White Sox are visiting the Houston Astros on Thursday, June 12^th at the Daikin Park in the third game of this series, with both teams being tied 1-1 wins. We will look at this from a betting perspective and determine the best bets for this game. Here’s a White Sox vs Astros Prediction. We will examine:

The Houston Astros recent form and player performance

The Chicago White Sox recent form and player performance

Recent betting trends and streaks involving the Houston Astros

Recent betting trends and streaks involving the Chicago White Sox

Recent betting trends in games played between the Chicago White Sox vs Houston Astros

A summary that ties it all together and produces a favorable betting outcome for the Chicago White Sox vs Houston Astros game

Houston Astros Preview

The Houston Astros have a 37-30 record this season and are sitting in first place in the AL West. The Astros have a 23-13 home record and 27-37 in over/under. They are coming off a 10-2 home victory over the White Sox, which ended their previous two-game losing streak. Under is 6-3 in their last 9 games, and they are playing the Athletics and the Twins next.

The Astros have a .254 batting average this season, a .318 OBP, and a .390 slugging percentage. Houston’s pitching staff has a 3.51 ERA and 1.16 WHIP. Jeremy Pena leads the Astros with 83 hits, and he is the team’s best hitter, with a .322 batting average. Isaac Paredes leads the team in RBI with 41, adding a team-high 14 home runs.

Framber Valdez (L) is the projected starter for the Astros, and he has a 6-4 record, 3.07 ERA, and 1.06 WHIP. He has been better at home, with a 2.20 ERA across six home starts, and he has been in very good form lately, having given up one earned run in four of his last six starts. In his previous start against the White Sox this season, he got hit for 4 earned runs in 5 innings pitched. Framber Valdez has a 4-3 record with an ERA of 2.94 and 48 strikeouts in 9 appearances against the White Sox in his career.

Chicago White Sox Preview

The Chicago White Sox have a 23-45 record this season and are sitting in last place in the AL Central. The White Sox have a 7-27 road record and are 32-32 in over/under. They are coming off a 2-10 road defeat by the Astros, and are 4-2 in their last 6 games. Over is 6-3 in their last 9 games, and they are playing the Rangers and the Cardinals next.

The White Sox have a .222 batting average this season, a .296 OBP, and a .343 Slugging percentage. Chicago’s pitching staff has a 4.19 ERA and 1.39 WHIP. Lenyn Sosa leads the White Sox with 55 hits, while Miguel Vargas leads the team in RBI, with 30, in home runs, with 9, while being the team’s best hitter with a team-high .233 batting average

Davis Martin (R) is the projected starter for the White Sox, and he has a 2-6 record, 3.62 ERA, and 1.21 WHIP. He has been weaker on the road with a 4.36 ERA across five road starts, but he has given up two runs or less in four of his last five starts. In his previous start against the Astros this season, he gave up 3 runs in 5 innings of work.

Why the Houston Astros will win

• The White Sox have lost each of their last seven games against American League opponents following a road loss.
• The Astros have won 14 of their last 15 Thursday games against American League opponents that held a losing record.
• The Astros have covered the run line each of their last seven Thursday games against American League opponents that held a losing record.
• The White Sox have failed to cover the run line in four of their last five games against American League opponents following a road loss.
• The Astros have led after 5 innings in four of their last five night games against American League opponents that held a losing record.
• The Astros have won the first inning in three of their last four games against opponents that held a winning record at Daikin Park.
• The Astros have led after 3 innings in four of their last five night games against American League opponents that held a losing record.

Why the Chicago White Sox will win

• The White Sox have won five of their last six games as underdogs against AL West opponents following a loss.
• The Astros have lost 13 of their last 18 games as favorites following a home win.
• The White Sox have covered the run line in seven of their last eight night games against the Astros following a loss.
• The Astros have failed to cover the run line in each of their last four night games against the White Sox following a home win.
• The Astros have trailed after 3 innings in six of their last eight home games against AL Central opponents.
• The Astros have trailed after 5 innings in seven of their last eight home games against AL Central opponents.

Total Runs Facts

• Each of the White Sox’s last six night games after playing the previous day have gone OVER the total runs line.
• Four of the Astros’ last five night games against AL Central opponents have gone UNDER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in eight of the Astros’ last nine games against AL Central opponents.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in four of the White Sox’s last five night games against AL West opponents.

Matchup/League Facts

• The Astros rank 1st in the league for strikeouts this season (648).
• The Astros rank 1st in the league for opponent batting average this season (.219).
• The White Sox rank 30th in the league for hits this season (490).
• The White Sox rank 30th in the league for batting average this season (.222).

White Sox vs Astros Prediction

The White Sox are 3-2 in their 5 meetings against the Astros this season, and are 4-1 to the over. The Astros were 4-1 in their 5 meetings before that, and under was 6-1 prior to those three meetings.

In this White Sox vs Astros Prediction, the Astros are coming as -260 home favorites. Houston is rightfully favored, as they have a better overall record and have been very strong at home, while Chicago is one of the weakest road teams in the majors. The Astros have the pitching advantage, as Valdez has been excellent lately, while Martin for the White Sox is due to some negative regression, with an expected ERA of 5.56. The Astros also have the 5^th-best bullpen in the league, and have a better offense, so I expect them to get the job done easily, just like yesterday. Take the Houston Astros on the runline in this one.