White Sox vs Astros Prediction 6/10/25 MLB Picks Today

The Chicago White Sox are visiting the Houston Astros on Tuesday, June 10^th at the Daikin Park in the opening game of this series. We will look at this from a betting perspective and determine the best bets for this game. Here’s a White Sox vs Astros Prediction. We will examine:

The Houston Astros’ recent form and player performance

The Chicago White Sox’s recent form and player performance

Recent betting trends and streaks involving the Houston Astros

Recent betting trends and streaks involving the Chicago White Sox

Recent betting trends in games played between the Chicago White Sox vs Houston Astros

A summary that ties it all together and produces a favorable betting outcome for the Chicago White Sox vs Houston Astros game

Houston Astros Preview

The Houston Astros have a 36-29 record this season and are sitting in first place in the AL West. The Astros have a 22-12 home record and 26-36 in over/under. They are coming off a 2-4 road defeat against the Guardians, which snapped their previous three-game winning streak. Under is 5-2 in their last 7 games, and they are playing the Athletics and the Twins next.

The Astros have a .250 batting average this season, a .316 OBP, and a .386 slugging percentage. Houston’s pitching staff has a 3.52 ERA and 1.16 WHIP. Jeremy Pena leads the Astros with 79 hits, and he is the team’s best hitter, with a .315 batting average. Isaac Paredes leads the team in RBI with 38, adding a team-high 14 home runs.

Lance McCullers Jr. (R) will take the mound for the Astros, and he has a 1-1 record, 4.44 ERA, and 1.40 WHIP. He has been terrible in his three home starts this season, with a 10.13 ERA, but he is coming off a shutout start in 6 innings pitched against the Pirates. His previous start against the White Sox this season was a shutout start in 3.2 innings pitched. Lance McCullers Jr. has a 4-1 record with an ERA of 1.98 and 47 strikeouts in 7 appearances versus the White Sox in his career.

Chicago White Sox Preview

The Chicago White Sox have a 22-44 record this season and are sitting in last place in the AL Central. The White Sox have a 6-26 road record and are 31-31 in over/under. They are coming off a 5-7 home defeat by the Royals, which ended their previous three-game winning streak. Over is 5-2 in their last 7 games, and they are playing the Rangers and the Cardinals next.

The White Sox have a .223 batting average this season, a .296 OBP, and a .345 Slugging percentage. Chicago’s pitching staff has a 4.12 ERA and 1.37 WHIP. Lenyn Sosa leads the White Sox with 55 hits and a team-high .274 batting average. Miguel Vargas leads the team in RBI, with 29, and in home runs, with 9.

Shane Smith (R) will take the mound for the White Sox, and he has a 2-3 record, 2.45 ERA, and 1.14 WHIP. He has been good on the road with a 2.76 ERA across six road starts, and he is coming off a shutout start in 5.1 innings of work against the Tigers. This will be his first career start against the Astros.

Why the Houston Astros will win

• The Astros have won each of their last 10 games at Daikin Park following a loss.
• The White Sox have lost each of their last eight road games against American League opponents.
• The Astros have covered the run line in 10 of their last 11 home games against American League opponents following a road loss.
• The White Sox have failed to cover the run line in five of their last six road games against American League opponents following a home loss.
• The White Sox have trailed after 5 innings in six of their last seven road games against American League opponents that held a winning record.
• The White Sox have trailed after 3 innings in four of their last five night games against opponents that held a winning record.

Why the Chicago White Sox will win

• The White Sox have won seven of their last eight games as underdogs following a home loss.
• The Astros have lost four of their last five games against AL Central opponents that held a losing record.
• The White Sox have covered the run line in each of their last eight games following a home loss.
• The Astros have failed to cover the run line in each of their last five games as favorites against American League opponents following a loss.
• The Astros have trailed after 3 innings in five of their last six home games against AL Central opponents.
• The Astros have trailed after 5 innings in each of their last six home games against AL Central opponents.
• The Astros have lost the first inning in three of their last four games against AL Central opponents that held a losing record.

Total Runs Facts

• Seven of the White Sox’s last eight road games against American League opponents have gone UNDER the total runs line.
• Four of the Astros’ last five games against AL Central opponents have gone UNDER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Astros’ last seven games against AL Central opponents.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in five of the White Sox’s last six night games against AL West opponents.

Matchup/League Facts

• The Astros rank 1st in the league for strikeouts this season (623).
• The Astros rank T1st in the league for hits allowed this season (464).
• The White Sox rank 29th in the league for slugging percentage this season (.345).
• The White Sox rank 28th in the league for hits this season (478).

White Sox vs Astros Prediction

The White Sox won their previous series against the Astros this season with 2-1 wins, with all three games going over the total. The Astros were 4-1 in their 5 meetings before that, and under was 6-1 prior to those three meetings.

In this  White Sox vs Astros Prediction, the Astros are coming as -190 home favorites. The Astros are rightfully favored, as they have a superior overall record and have been very strong at home, while the White Sox are one of the weakest road teams in the whole league. The White Sox might seem to have the pitching advantage, but McCullers is coming off a shutout start, and his previous start against the White Sox was also a shutout. The Astros have a better bullpen, and are way better against lefties, so I expect them to get the job done at home today. Take the Houston Astros on the moneyline.