White Sox vs Giants Prediction 6/27/25 MLB Picks Today

In this article, we will formulate a White Sox vs Giants prediction for this MLB game on Friday, June 27, at Rate Field in Chicago, Illinois. Let’s take a look at the prediction for this MLB matchup.

San Francisco Giants Betting Preview

The San Francisco Giants (44-37, 19-20 Away) spent the previous three series at home, where they lost to the Cleveland Guardians, beat the Boston Red Sox, and were shockingly swept by the Miami Marlins in three games. In the latest 12-5 defeat, Rafael Devers and Brett Wisely led the offense with two RBI apiece, while Hayden Birdsong took the loss after allowing seven runs on four hits with one strikeout and four walks in 4.0 innings.

This season, the Giants average 4.25 runs per game (16th in the MLB) on a .232/.313/.375 triple-slash. When it comes to pitching, the Giants’ staff has a 3.42 ERA (5th) and 1.24 WHIP (11th). Wilmer Flores leads the Giants with a .243 batting average, 11 home runs, and 54 RBI this season.

Landen Roupp will take the mound for the Giants on Friday. The 26-year-old right-hander has a 5-5 record in 15 starts this year with a 3.67 ERA and 1.42 WHIP in 76.0 innings.

Chicago White Sox Betting Preview

The Chicago White Sox (26-55, 17-23 Home) surprisingly defeated the Toronto Blue Jays in two out of three games on the road, but then returned to losing ways, suffering a couple of home defeats to the Arizona Diamondbacks. However, the White Sox avoided getting swept with a 7-3 victory in Game 3. Lenyn Sosa led his offense with two home runs and four RBI, while Sean Burke got the win after allowing two runs (none earned) on five hits with seven strikeouts and two walks across 5.0 innings of work.

This year, the White Sox average 3.46 runs per game (28th in the MLB) on a .220/.293/.345 triple-slash. When it comes to pitching, the White Sox’s staff has a 4.18 ERA (21st) and 1.40 WHIP (26th). Miguel Vargas leads the White Sox with a .233 batting average, ten home runs, and 34 RBI this season.

The projected starting pitcher for the White Sox is Aaron Civale, who is 1-4 in seven starts this season, with a 5.03 ERA and 1.47 WHIP in 34.0 innings.

Why the Giants will beat the White Sox

• The White Sox have lost each of their last 10 night games against NL West opponents that held a winning record.
• The Giants have won five of their last six games against AL Central opponents following a home loss.
• The Giants have covered the run line in each of their last five road games following a loss.
• The White Sox have failed to cover the run line each of their last five night games against National League opponents that held a winning record.
• The Giants have led after 3 innings in each of their last three games as favorites against American League opponents.

Total Runs Facts

• Each of the Giants’ last six games against AL Central opponents have gone UNDER the total runs line.
• Each of the last three games between the Giants and White Sox at Rate Field have gone OVER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in seven of the Giants’ last eight games as favorites against American League opponents.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in seven of the White Sox’s last eight games as underdogs against National League opponents.

Matchup/League Facts

• The White Sox rank 29th in the league for slugging percentage this season (.345).
• The White Sox rank 29th in the league for strikeouts this season (584).
• The Giants rank 5th in the league for ERA this season (3.42).
• The Giants rank 25th in the league for hits this season (616).

White Sox vs Giants Prediction

The White Sox won six of the previous ten H2H encounters, but the Giants were better in three of the last four. I am backing the Giants here because they have an advantage in the pitching matchup. Landen Roupp was fantastic in May, and although his numbers weren’t that good in June, he is still in better form than Aaron Civale. Civale allowed multiple runs in his last four starts, and seven in total in two starts since he joined the club from the Brewers. Following a disastrous outcome in a series against the Marlins, I am sure the Giants will bounce back with a win here. Back them to do it.