White Sox vs. Guardians Pick – MLB Predictions & Odds 5/16/23

White Sox vs. Guardians Pick – MLB Predictions & Odds 5/16/23 player photo
Credit: USA Today Sports

The Cleveland Guardians and the Chicago White Sox meet in an AL Central division matchup in MLB action from Guaranteed Rate Field on Tuesday night. Let’s dive into the odds, starting pitching matchup, history and make a prediction for this game.


Cleveland is listed as a -130 road favorite while Chicago is a +110 home underdog. The total for this game is set at 8 runs.

Starting Pitching Matchup

Shane Bieber will start for Cleveland here and is 3-1 with a 2.61 ERA and 39 strikeouts this season. Lance Lynn will start for Chicago and is 1-5 with a 7.51 ERA and 54 strikeouts this season.

Matchup History

Cleveland’s 4-2 win back on September 22nd, 2022, made it three straight wins for the Guardians in this head-to-head matchup.


Cleveland is 1-4 in their last 5 road games and 31-15 in their last 46 division games while the under is 21-5-2 in their last 28 games overall. Chicago is 9-20 in their last 29 home games and 1-4 in their last 5 games overall while the under is 4-0 in their last 4 games following a loss.


I’m backing the Guardians here. Cleveland’s the better team here with a clear pitching edge and I just don’t see the White Sox being able to do enough to keep themselves in the game here. Lynn’s struggled in a lot of spots this season and I look for this game to be no different. Give me the Guardians.

Chris Ruffolo's Free Pick:Cleveland -130