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White Sox vs Guardians Prediction 7-12-25 MLB Picks

Cleveland Guardians (44-49) vs. Chicago White Sox (32-63)
July 12, 2025 8:10 pm EDT
The Line: Chicago White Sox 123 / Cleveland Guardians -150; Over/Under: 8.5
(Get latest betting odds)

In this article, we will formulate a White Sox vs Guardians prediction for this MLB game on Saturday, July 12th at Rate Field in Chicago, Illinois. Let’s take a look at the prediction for this MLB matchup. 

Chicago White Sox Betting Preview

The Chicago White Sox are 32-63 this year after they split the first two games in this series by scores of 2-4 and 5-4. In their game two win, Chicago blew a 3-2 lead in the middle innings, but they tied the game in the eighth and won in the 11th. The White Sox recorded six hits in the game, and they were led by Sosa, who went 2-4 with two home runs and two RBIs in the win. Chicago started Cannon, who allowed three hits and two earned runs over 5.0 innings, while Vasil picked up the win in relief. 

Prior to this series, the White Sox lost two out of three against the Blue Jays, but did win two out of three against the Rockies before that. Chicago has won two of their last three games, and they are currently last in the AL Central standings. The Chicago pitching staff has a 4.13 ERA with a 1.39 WHIP and a .253 opponent batting average, while the offense has scored 325 runs with a .220 batting average and a .296 on-base percentage this season. Miguel Vargas has led Chicago with 10 home runs and 35 RBIs, while Andrew Benintendi has also added 10 home runs and 34 RBIs this year. The projected starting pitcher for Chicago is Sean Burke, who is 4-8 with a 4.40 ERA and a 1.42 WHIP over 92.0 innings pitched this year. 

Cleveland Guardians Betting Preview

The Cleveland Guardians are 44-49 this season after they lost game two by a score of 4-5 on Friday night. Cleveland led 2-1 and 4-3, but they couldn’t hold the lead in the extra innings loss. The Guardians recorded eight hits and they committed one error in the game, while they were led by Ramirez, who went 1-4 with one home run and two RBIs in the loss. Cleveland started Williams, who allowed four hits and three earned runs over 5.0 innings, while Allard picked up the loss. 

Prior to this series, the Guardians swept the Astros in three games, but lost all three against the Tigers before that. Cleveland has won four of their last five games, and they are currently fourth in the AL Central standings. The Cleveland pitching staff has a 3.93 ERA with a 1.35 WHIP and a .246 opponent batting average, while the offense has scored 341 runs with a .223 batting average and a .295 on-base percentage this season. Jose Ramirez has led Cleveland with 18 home runs and 47 RBIs, while Kyle Manzardo has added 13 home runs and 33 RBIs this year. The projected starting pitcher for Cleveland is Tanner Bibee, who is 4-9 with a 4.35 ERA and a 1.23 WHIP over 103.1 innings pitched this season. 

Why the White Sox will beat the Guardians

  • The White Sox have won four of their last five games as home underdogs after going to extra innings.
  • The Guardians have lost four of their last five games as favorites after going to extra innings.
  • The White Sox have covered the run line in each of their last nine games against American League opponents after going to extra innings.
  • The Guardians have failed to cover the run line in 11 of their last 12 games as favorites after going to extra innings.
  • The Guardians have trailed after 5 innings in three of their last four road games against AL Central opponents.

Total Runs Facts

  • Seven of the White Sox’s last eight day games after playing the previous day have gone UNDER the total runs line.
  • Six of the Guardians’ last seven games after going to extra innings have gone UNDER the total runs line.
  • The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Guardians’ last 11 day games against American League opponents.
  • The ‘Inning 1 UNDER 0.5 runs’ market has hit in nine of the last 10 day games between the Guardians and White Sox at Rate Field.

Chicago White Sox Player Prop Facts

  • Luis Robert has hit a home run in three of his last 10 appearances with the White Sox as home underdogs against the Guardians.
  • Luis Robert has recorded at least one hit in 14 of his last 16 appearances against the Guardians.
  • Michael A. Taylor has recorded a Double in three of his last four appearances after playing the previous day.

Cleveland Guardians Player Prop Facts

  • Jose Ramirez has hit a home run in four of the Guardians’ last five games against AL opponents.
  • Will Brennan has recorded at least one Double in each of his last three appearances with the Guardians as favorites against AL opponents.
  • Lane Thomas has recorded at least one hit in each of his 12 previous road appearances against AL Central opponents that held a losing record.

White Sox vs Guardians Prediction 

These two teams split the doubleheader on Friday to open this series, but Cleveland has won four of their last five games. The Guardians are 24-26 on the road this year, while the White Sox are 21-27 at home. Chicago is still the worst team in the AL Central by a wide margin, but they are starting Burke, who has allowed one earned run or fewer in three of his last four outings. Cleveland is going with Bibee, who has allowed at least four earned runs in three of his last four starts. Take the White Sox to get the win here. 

David Racey's Free Pick: White Sox ML

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David Racey

David started writing about sports in 2015, but sports has been his passion for as long as he can remember. David spends most of his free time watching pretty much anything sports related from Baseball to Tennis and everything in between. David likes to analyze statistics and recent results to form an unbiased opinion on whatever game he is breaking down. Follow David on Twitter at @itsyerboi41

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