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Yankees vs Blue Jays Prediction 5/21/26 MLB Picks Today

Toronto Blue Jays (22-27) vs. NY Yankees (30-20)
May 21, 2026 7:05 pm EDT
The Line: NY Yankees -175 / Toronto Blue Jays 144; Over/Under: 8
(Get latest betting odds)

The Toronto Blue Jays and New York Yankees meet Thursday in MLB action at Yankee Stadium. Here’s a Yankees vs Blue Jays Prediction. This article will include a Yankees vs Blue Jays Pick.

Toronto Blue Jays Betting Preview

The Toronto Blue Jays are 22-27 on the year and play the Marlins and Pirates next. The Toronto Blue Jays are batting .243 on the season and have a .306 OBP, and a .369 slugging percentage. The Toronto Blue Jays’ pitching staff has a 4.00 ERA and a 1.29 WHIP. Ernie Clement leads the Toronto Blue Jays with 53 hits and 16 RBI while Daulton Varsho and Vladimir Guerrero Jr. have combined for 96 hits and 37 RBI.

Braydon Fisher gets the ball for the Toronto Blue Jays, and he is 2-1 with a 3.08 ERA and 24 strikeouts this season. Fisher is 1-0 with a 3.00 ERA and 9 strikeouts in his career against the New York Yankees.

New York Yankees Betting Preview

The New York Yankees are 30-20 on the year and play the Royals and Rays next. The New York Yankees are batting .235 on the season and have a .330 OBP, and a .429 slugging percentage. The New York Yankees’ pitching staff has a 3.34 ERA and a 1.17 WHIP. Cody Bellinger leads the New York Yankees with 48 hits and 32 RBI while Ben Rice and Aaron Judge have combined for 92 hits and 63 RBI.

Carlos Rodon gets the ball for the New York Yankees, and he is 0-1 with a 5.63 ERA and 10 strikeouts this season. Rodon is 2-3 with a 4.72 ERA and 54 strikeouts in his career against the Toronto Blue Jays.

Why the New York Yankees will win

  • The Yankees have won each of their last nine night games at Yankee Stadium following a loss.
  • The Blue Jays have lost seven of their last eight road games against the Yankees following a win.
  • The Yankees have covered the run line in each of their last seven Thursday night games.
  • The Blue Jays have failed to cover the run line in three of their last four night games following a win.
  • The Yankees have led after 3 innings in nine of their last 11 home games against AL East opponents that held a losing record.
  • The Yankees have led after 5 innings in each of their last seven Thursday night games as home favorites.

Why the Toronto Blue Jays will win

  • The Blue Jays have won each of their last seven Thursday night games as underdogs against American League opponents.
  • The Yankees have lost six of their last nine games as favorites after playing the previous day.
  • The Blue Jays have covered the run line in each of their last 13 Thursday games as underdogs.
  • The Yankees have failed to cover the run line in eight of their last nine games as favorites after playing the previous day.

Total Runs Facts

  • Five of the Blue Jays’ last six games against AL East opponents have gone OVER the total runs line.
  • Five of the Yankees’ last six home games against AL East opponents have gone OVER the total runs line.
  • The ‘Inning 1 UNDER 0.5 runs’ market has hit in six of the Yankees’ last seven games.
  • The ‘Inning 1 UNDER 0.5 runs’ market has hit in four of the Blue Jays’ last five games as road underdogs.

New York Yankees Player Prop Facts

  • Carlos Rodon has recorded six or more strikeouts in four of his five previous home appearances against the Blue Jays.
  • Cody Bellinger has recorded at least one hit in each of his last 16 home appearances.
  • Giancarlo Stanton has hit at least one home run in three of his last four home appearances against AL East opponents that held a losing record.
  • Carlos Rodon has recorded a win in seven of his last eight home appearances against AL opponents that held a losing record.
  • Ben Rice ranks 1st amongst qualified players for Slugging Percentage (.654) this season.

Toronto Blue Jays Player Prop Facts

  • Daulton Varsho has hit a home run in four of his last five Thursday night appearances.
  • Ernie Clement has recorded at least one hit in 22 of his last 23 road appearances against opponents that held a winning record.

Matchup/League Facts

  • The Yankees rank 1st in the league for home runs this season (73).
  • The Yankees rank 2nd in the league for walks this season (226).
  • The Blue Jays rank T1st in the league for strikeouts against them this season (342).
  • The Blue Jays rank T29th in the league for triples this season (2).

Yankees vs Blue Jays Prediction

The Blue Jays haven’t had success on the road and have underachieved overall up to this point. The Yankees are the better team at home, and Rodon on the mound will make them favorites. However, Rodon has pitched just 8 innings this season and hasn’t been good with his 5.63 ERA and 1.63 WHIP. He needs to get reps under his belt. Fisher has 26.1 frames and has been respectable with a 3.08 ERA and 1.06 WHIP. The Blue Jays have also had success against Rodon through 104 at-bats with a .279 batting average and .364 on-base percentage. I’ll take a shot with the Jays and the plus money.

Randy Chambers's Free Pick: Toronto Blue Jays 144

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Randy Chambers

Randy has covered sports betting since 2014 and writes about everything from NFL to WNBA. Follow Randy Chambers on Twitter.

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