Yankees vs Cardinals Prediction 8/17/25 MLB Picks Today

In this article, we will formulate a Yankees vs Cardinals Prediction for this MLB game on Sunday, August 17^th at the Busch Stadium in the third game of this series, with the Yankees having the 2-0 lead. Let’s take a look at the prediction for this MLB matchup.

Saint Louis Cardinals Preview

The Saint Louis Cardinals have a 61-63 record this season and are sitting on the 4^th place of the NL Central. The Cardinals have a 35-29 home record and are 61-57 in over/under They are coming off an 8-12 home defeat by the Yankees, and have four consecutive losses. Under is 6-3 in their last 9 games and are playing the Marlins and the Rays next.

The Cardinals have a .250 batting average this season, .318 OBP and .388 Slugging percentage. Saint Louis’ pitching staff has a 4.25 ERA and 1.29 WHIP. Brendan Donovan leads the Cardinals with 118 hits, while Alec Burleson is the team’s best hitter with a .284 batting average. Wilson Contreras leads the team in RBI, with 65, adding a team-high 16 home runs.

Miles Mikolas (R) is the projected starting pitcher for the Cardinals, and he has a 6-9 record, 4.97 ERA and 1.28 WHIP.

New York Yankees Preview

The New York Yankees have a 66-57 record this season and are sitting on the third place of the AL East. The Yankees have a 29-32 road record and are 55-63 in over/under. They are coming off a 12-8 road victory over the Cardinals, and are 4-1 in their last 5 games. Under is 4-2 in their last 6 games and are playing the Rays and the Red Sox next.

The Yankees have a .250 batting average this season, .330 OBP and .447 Slugging percentage. New York’s pitching staff has a 4.04 ERA and 1.25 WHIP. Aaron Judge leads the Yankees with 136 hits, adding team-highs both in RBI, with 91 and in home runs, with 39. He is also the team’s best hitter, with a .333 batting average.

Will Warren (R) is the projected starting pitcher for the Yankees, and he has a 7-5 record, 4.34 ERA and 1.27 WHIP.

Why the St. Louis Cardinals will win

• The Yankees have lost five of their last six games as road favorites following a win.
• The Cardinals have won nine of their last 10 day games against AL East opponents that held a winning record.
• The Cardinals have covered the run line in nine of their last 10 day games against AL East opponents that held a winning record.
• The Yankees have failed to cover the run line in eight of their last nine road games.
• The Cardinals have led after 3 innings in seven of their last eight games against American League opponents.
• The Cardinals have led after 5 innings in each of their last five day games against the Yankees.
• The Cardinals have won the first inning in four of their last five day games against American League opponents.

Why the New York Yankees will win

• The Cardinals have lost each of their last six games against AL East opponents that held a winning record.
• The road team has won each of the Cardinals’ last four games.
• The Cardinals have failed to cover the run line in eight of their last nine home games against American League opponents.
• The Yankees have covered the run line in six of their last seven games against NL Central opponents that held a losing record.
• The Yankees have led after 3 innings in five of their last six day games against NL Central opponents that held a losing record.
• The Cardinals have trailed after 5 innings in each of their last 10 home games against American League opponents that held a winning record.
• The Cardinals have lost the first inning in seven of their last eight home games against American League opponents that held a winning record.

Total Runs Facts

• Six of the Cardinals’ last seven games as underdogs against American League opponents have gone OVER the total runs line.
• Five of the Yankees’ last six games as favorites against National League opponents have gone OVER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Cardinals’ last eight home games against American League opponents.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in seven of the Yankees’ last eight games.

Matchup/League Facts

• The Cardinals rank 30th in the league for triples this season (5).
• The Cardinals rank 29th in the league for strikeouts this season (905).
• The Yankees rank 1st in the league for home runs this season (195).
• The Yankees rank 1st in the league for slugging percentage this season (.447).

Yankees vs Cardinals Prediction

The Cardinals are 7-4 in their last 11 meetings against the Yankees, and are 5-3 in their last 8 meetings in Saint Louis. Over is 4-1 in their last 5 meetings.

In this Yankees vs Cardinals Prediction, the Yankees are coming as -150 road favorites. I don’t trust either pitcher in this matchup, as they both have a combined 9.31 ERA, and Warren has been terrible on the road for the Yankees, with a 6.48 road ERA, and Mikolas has been in mediocre form for the Cardinals, with a 5.11 ERA across his last 5 starts. The Yankees have the third-best offense in the league with 5.1 runs per game, and with yesterday’s game going way over the total with 20 total runs, I like another high-scoring affair today. Take the over 9 runs in this one.