76ers vs Cavaliers Prediction 1/16/26 NBA Picks Today
Cleveland Cavaliers (23-19) vs. Philadelphia 76ers (22-17)
January 16, 2026 7:00 pm EDT
The Line: Philadelphia 76ers -1.5; Over/Under: 234.5
(Get latest betting odds)
The Cleveland Cavaliers and Philadelphia 76ers meet Friday in NBA action at the Xfinity Mobile Arena. Here’s a 76ers vs Cavaliers Prediction. This article will include a 76ers vs Cavaliers Pick.
Cleveland Cavaliers Betting Preview
The Cleveland Cavaliers beat the 76ers, lost to the Jazz, and they play the Thunder next. The Cavs have won 6 of their last 9 games.
The Cleveland Cavaliers are averaging 120.1 points on 47.2 percent shooting and allowing 117.5 points on 46.6 percent shooting. Donovan Mitchell is averaging 29.7 points and 5.6 assists, while Darius Garland is averaging 18 points and 6.9 assists. Evan Mobley is the third double-digit scorer and De’Andre Hunter is grabbing 4.3 rebounds. The Cleveland Cavaliers are shooting 35.7 percent from beyond the arc and 78.2 percent from the free throw line. The Cleveland Cavaliers are allowing 38.3 percent shooting from deep and are grabbing 44.4 rebounds per game.
Philadelphia 76ers Betting Preview
The Philadelphia 76ers lost to the Cavs, beat the Raptors, and they play the Pacers next. The 76ers have won 6 of their last 9 games.
The Philadelphia 76ers are averaging 116.9 points on 45.4 percent shooting and allowing 115.6 points on 46.4 percent shooting. Tyrese Maxey is averaging 30.5 points and 6.6 assists, while Joel Embiid is averaging 23.5 points and 7 rebounds. Paul George is the third double-digit scorer and VJ Edgecombe is grabbing 5.3 rebounds. The Philadelphia 76ers are shooting 35.6 percent from beyond the arc and 82 percent from the free-throw line. The Philadelphia 76ers are allowing 33.9 percent shooting from deep and are grabbing 44.3 rebounds per game.
Why the Philadelphia 76ers will win
- The 76ers have won each of their last five games against the Cavaliers after losing as favorites.
- The Cavaliers have lost each of their last four road games following a win.
- The 76ers have covered the spread in each of their last nine home games against the Cavaliers following a loss.
- The Cavaliers have failed to cover the spread in each of their last nine games against Eastern Conference opponents after winning as underdogs.
Why the Cleveland Cavaliers will win
- The 76ers have lost each of their last eight home games against teams that held a winning record.
- The underdogs have won four of the Cavaliers’ last five games at Xfinity Mobile Arena.
- The 76ers have failed to cover the spread in each of their last seven home games against teams that held a winning record.
- The Cavaliers have covered the spread in 11 of their last 12 games as road underdogs against Eastern Conference opponents.
Total Points Facts
- Each of the 76ers’ last nine Friday games have gone UNDER the total points line.
- Each of the Cavaliers’ last four games as underdogs following a road win have gone OVER the total points line.
Philadelphia 76ers Player Facts
- Tyrese Maxey ranks 1st in the league for fast break points (208) this season.
- Andre Drummond ranks 1st amongst qualified players for rebounds per 36 minutes (15.8) this season.
Cleveland Cavaliers Player Facts
- Donovan Mitchell ranks 2nd amongst qualified players for three-pointers made per game (3.9) this season.
- Evan Mobley rank 3rd amongst qualified players for steals + blocks per game (2.8) this season.
Matchup/League Facts
- The 76ers rank 1st in the league for Q2 points per game this season (30.7).
- The 76ers rank 30th in the league for Q3 points per game this season (26.6).
- The Cavaliers rank 30th in the league for opponent three-point percentage this season (38.3%).
- The Cavaliers rank 1st in the league for Q4 points per game this season (30.8).
76ers vs Cavaliers Injury Report
Dominick Barlow is questionable for the 76ers.
The Cavs will be without Max Strus, Sam Merrill, Darius Garland, and Dean Wade.
76ers vs Cavaliers Prediction
The Cavaliers are starting to win games, and they’ve won 5 of the last 6 games against the 76ers. Of course, one of those wins was a blowout on Wednesday. However, the Cavs are a bit more banged up tonight than they were a couple of days ago. Also, despite the wins, the Cavs are still 13-29 ATS on the season, which makes them the worst cover team in the NBA. The 76ers haven’t strung together losses much this season, and they’re a profitable 23-15-1 ATS on the season. This matchup simply comes down a team that cashes tickets against one that doesn’t. Give me the 76ers and the small number.

