Cavaliers vs Pacers Prediction 11/21/25 NBA Picks Today

The Indiana Pacers and Cleveland Cavaliers meet Friday in NBA action at the Rocket Arena. Here’s a Cavaliers vs Pacers Prediction. This article will include a Cavaliers vs Pacers Pick.

Indiana Pacers Betting Preview

The Indiana Pacers lost to the Pistons, beat the Hornets, and they play the Pistons next. The Pacers have lost 13 of their last 15 games.

The Indiana Pacers are averaging 108.7 points on 40.1 percent shooting and allowing 123.2 points on 48.4 percent shooting. Bennedict Mathurin is averaging 31 points and 7 rebounds, while Pascal Siakam is averaging 24.6 points and 7.1 rebounds. Andrew Nembhard is the third double-digit scorer, and Aaron Nesmith is grabbing 4.5 rebounds. The Indiana Pacers are shooting 30 percent from beyond the arc and 77.2 percent from the free-throw line. The Indiana Pacers are allowing 33 percent shooting from deep and are grabbing 46.8 rebounds per game.

Cleveland Cavaliers Betting Preview

The Cleveland Cavaliers beat the Bucks, lost to the Rockets, and they play the Clippers next. The Cavs have won 10 of their last 15 games.

The Cleveland Cavaliers are averaging 121.1 points on 45.3 percent shooting and allowing 117 points on 46.6 percent shooting. Donovan Mitchell is averaging 30.4 points and 5.4 assists, while Evan Mobley is averaging 19.2 points and 4.2 assists. De’Andre Hunter is the third double-digit scorer and Jarrett Allen is grabbing 7.8 rebounds. The Cleveland Cavaliers are shooting 34.7 percent from beyond the arc and 76.3 percent from the free throw line. The Cleveland Cavaliers are allowing 37.1 percent shooting from deep and are grabbing 43.8 rebounds per game.

Why the Cleveland Cavaliers will win

• The Cavaliers have won each of their last 17 home games against Central Division opponents that held a losing record.
• The Pacers have lost each of their last 11 road games.
• The Pacers have failed to cover the spread in each of their last six road games against teams that held a winning record.
• The home team has covered the spread in six of the Pacers’ last seven games.

Why the Indiana Pacers will win

• The Pacers have won each of their last four games as road underdogs against the Cavaliers.
• The Cavaliers have lost three of their last four games as home favorites against Eastern Conference opponents following a loss.
• The Pacers have covered the spread in eight of their last nine road games against the Cavaliers.
• The Cavaliers have failed to cover the spread in six of their last seven home games against Central Division opponents.

Total Points Facts

• Each of the Pacers’ last six games as underdogs following a home win have gone UNDER the total points line.
• Six of the Cavaliers’ last seven games against Eastern Conference opponents have gone OVER the total points line.

Cleveland Cavaliers Player Facts

• Donovan Mitchell ranks 3rd amongst qualified players for three-pointers made per game (3.9) this season.
• Evan Mobley rank T8th in the league for total steals + blocks (39) this season.

Indiana Pacers Player Facts

• Andrew Nembhard ranks 2nd in the Eastern Conference amongst qualified players for FT% (92.9%) this season.
• Pascal Siakam is one of only five qualified players in the league to be leading their team in points (24.7), rebounds (6.9) and assists (4.9) per game this season.

Matchup/League Facts

• The Cavaliers rank 1st in the league for three-point field goal attempts per game this season (45.0).
• The Cavaliers rank 1st in the league for H2 points per game this season (61.6).
• The Pacers rank 30th in the league for steals per game this season (6.3).
• The Pacers rank 30th in the league for field goal percentage this season (41.1%).

Cavaliers vs Pacers Injury Report

The Cavs will be without Max Strus and Sam Merrill. Jaylon Tyson, Jarrett Allen, and Darius Garland are questionable.

The Pacers will be without Tyrese Haliburton, Obi Toppin, Kam Jones, Aaron Nesmith, Johnny Furphy, and Quenton Jackson.

Cavaliers vs Pacers Prediction

The Pacers have been fade material all season long and despite a win over the Hornets, I’m still not thrilled to get behind them. However, the Cavs have a lengthy list of injuries themselves and while they’re winning, they’re 5-11 ATS on the year. I’m not laying double-digit chalk with a team that’s not covering numbers. The underdog has covered 6 of the last 9 games between the Pacers and Cavs. The Cavs are 1-4 ATS in their last 5 games as a double-digit favorite. I want the boatload of points with the Pacers.