NFL Picks: Arizona Cardinals vs Buffalo Bills 11/15/20 Predictions, Odds

The Buffalo Bills and Arizona Cardinals meet Sunday in a battle of playoff hopefuls in week 10 NFL action at State Farm Stadium in Phoenix.

The Buffalo Bills look to win a fourth straight game to keep their lead in the AFC East. The Buffalo Bills have won three of their last four road games. Josh Allen is completing 68.9 percent of his passes for 2,587 yards, 19 touchdowns and five interceptions. Allen has two or more touchdown passes in seven of his last nine games. Stefon Diggs and Cole Beasley have combined for 1,346 receiving yards and five touchdowns while John Bitemn has 23 receptions. The Buffalo Bills ground game is averaging 100.3 yards per contest, and Devin Singletary leads the way with 386 yards and one touchdown. Defensively, Buffalo is allowing 25.9 points and 364.9 yards per game. Jordan Poyer leads the Buffalo Bills with 79 tackles, Mario Addison has four sacks and Matt Milano has one interception.

The Arizona Cardinals look for a statement win after splitting their last six games. The Arizona Cardinals have split their last four home games. Kyler Murray is completing 68.1 percent of his passes for 2,130 yards, 16 touchdowns and seven interceptions. Murray has two or more touchdown passes in five of his last six games. DeAndre Hopkins and Christian Kirk have combined for 1,134 receiving yards and nine touchdowns while Larry Fitzgerald has 33 receptions. The Arizona Cardinals ground game is averaging 162.9 yards per contest, and Murray leads the way with 543 yards and eight touchdowns. Defensively, Arizona is allowing 22.5 points and 370.1 yards per game. Jordan Hicks leads the Arizona Cardinals with 66 tackles, Haason Reddick has five sacks and Patrick Peterson has two interceptions.

The Bills are 1-4-1 ATS in their last 6 road games, 1-3-1 ATS in their last 5 games as an underdog and 1-4 ATS in their last 5 games overall. The Cardinals are 2-6 ATS in their last 8 games as a favorite, 1-5 ATS in their last 6 games as a home favorite and 7-3-1 ATS in their last 11 games overall. The over is 6-2-1 in Bills last 9 games overall. The under is 6-2 in Cardinals last 8 games overall.

Right when it looked like the Buffalo Bills were hanging on by the skin of their teeth, they put together an impressive winning performance against the Seahawks. The Arizona Cardinals are explosive on the offensive side and are intriguing, but only one of their five wins this season have come against a team with a winning record. The Cardinals couldn’t get off the field against the Dolphins last week, and they’ve allowed 30-plus points in three of their last five games. The Cardinals are a fun team to watch, but not a team I’m confident in lying money on right now. It feels like we’re getting the better team and free points in this spot.

I’ll take the Bills in the underdog role.