49ers vs Rams Prediction 11/9/25 NFL Picks Today

The Los Angeles Rams and San Francisco 49ers meet Sunday in NFL action at Levi’s Stadium. Here’s a 49ers vs Rams Prediction. This article will include a 49ers vs Rams Pick.

Los Angeles Rams Betting Preview

The Los Angeles Rams beat the Jaguars and Saints, and they play the Seahawks next. The Rams have won 3 straight games. Matthew Stafford is completing 67.2 percent of his passes for 2,147 yards, 21 touchdowns, and 2 interceptions. Puka Nacua and Davante Adams have combined for 1,202 receiving yards and 11 touchdowns, while Kyren Williams has 20 receptions.

The Los Angeles Rams ground game is averaging 111.9 yards per contest, and Kyren Williams leads the way with 586 yards and 3 touchdowns. Defensively, Los Angeles is allowing 15.9 points and 302.9 yards per game. Nate Landman leads the Los Angeles Rams with 72 tackles, Byron Young has 9 sacks and Kam Curl has 2 interceptions.

San Francisco 49ers Betting Preview

The San Francisco 49ers beat the Giants, lost to the Texans, and play the Cardinals next. The San Francisco 49ers have split their last 6 games. Mac Jones is completing 67.2 percent of his passes for 1,832 yards, 10 touchdowns, and 5 interceptions. Kendrick Bourne and Christian McCaffrey have combined for 1,089 receiving yards and 4 touchdowns, while Ricky Pearsall has 20 receptions.

The San Francisco 49ers ground game is averaging 97.1 yards per contest, and Christian McCaffrey leads the way with 596 yards and 4 touchdowns. Defensively, San Francisco is allowing 20.9 points and 332.6 yards per game. Dee Winters leads the San Francisco 49ers with 59 tackles, Bryce Huff has 4 sacks and Deommodore Lenoir has 1 interception.

• The 49ers have won seven of their last eight games as underdogs against the Rams.
• The Rams have lost four of their last five Week 10 games as favorites.
• The 49ers have covered the spread in each of their last eight games as underdogs against the Rams.
• The Rams have failed to cover the spread in five of their last six Week 10 games.
• The Rams have lost the first quarter in four of their last five November games as road favorites.
• The 49ers have scored the first touchdown in five of their last six home games against NFC opponents.
• The 49ers have won the first half in eight of their last nine games in November.

Why the Los Angeles Rams will win

• The Rams have won each of their last 16 Sunday games as favorites.
• The 49ers have lost each of their last six games as moderate underdogs (+3.5 to +7.0 points).
• The 49ers have failed to cover the spread in each of their last 11 home games following a win.
• The Rams have covered the spread in each of their last 10 Sunday games as favorites.
• The 49ers have lost the first half in seven of their last eight Sunday games as underdogs.
• The Rams have won the first quarter in four of their last five games following a win.
• The Rams have scored the first touchdown in five of their last six games as road favorites against NFC opponents.

Total Points Facts

• Seven of the Rams’ last eight Sunday games as favorites have gone UNDER the total points line.
• Each of the 49ers’ last five Week 10 games have gone UNDER the total points line.
• Four of the last five games between teams from the same division have gone OVER the total points line.

San Francisco 49ers Player Prop Facts

• Brian Robinson has recorded 22+ rushing yards in each of his 10 previous appearances with his team as a home underdog.
• Brian Robinson has recorded 24+ rushing and receiving yards in each of his 11 previous November appearances.
• Christian McCaffrey has scored at least one touchdown in 11 of his last 12 home appearances against teams that held a winning record.
• Russell Gage has scored the last touchdown in three of his last four regular season appearances with his team as an underdog.
• Brock Purdy has recorded 277+ passing yards in each of his last four appearances.
• Christian McCaffrey has recorded 52+ receiving yards in each of the 49ers’ last seven games against NFC opponents.
• Brian Robinson has scored the first touchdown in three of his last four November appearances with his team as an underdog.
• Brock Purdy has recorded 22+ completions in each of his last four appearances.
• Heading into Week 10, Christian McCaffrey is the only player in the NFL to record 500 rushing yards and 500 receiving yards this season.

Los Angeles Rams Player Prop Facts

• Kyren Williams has recorded 94+ rushing yards in each of the Rams’ last four road games against NFC opponents.
• Kyren Williams has recorded 95+ rushing and receiving yards in each of the Rams’ last six road games against NFC opponents.
• Kyren Williams has scored at least one touchdown in nine of his last 10 appearances with the Rams as favorites against NFC opponents.
• Kyren Williams has scored two or more touchdowns in three of his four previous appearances against the 49ers.
• Matthew Stafford has recorded 298+ passing yards in each of the Rams’ last five games as favorites following a home win.
• Tyler Higbee has recorded 20+ receiving yards in 12 of his last 13 regular season road appearances against NFC West opponents.
• Matthew Stafford has recorded 23+ completions in each of the Rams’ last six games as favorites following a home win.
• Heading into Week 10, Davante Adams ranks 1st in the NFL in receiving touchdowns (8) this season.

Matchup/League Facts

• Heading into Week 10, the 49ers have recorded the most wins by a margin of 10 points or less this season (6).
• Heading into Week 10, the 49ers have recorded the equal-most wins by a margin of five points or less this season (4).
• Heading into Week 10, the Rams rank 1st in the NFL in passing yards per game (258.0) this season.
• Heading into Week 10, the Rams rank 32nd in the NFL in kickoff return yards per game (69.5) this season.

49ers vs Rams Prediction

The Rams are getting the benefit of the doubt because they’ve been the better, healthier team this season and Puka is expected to return. The 49ers have been hit or miss at times, and their offense continues to have issues finishing drives. However, these are two of the better coached teams in the league, and I usually want points where I can get them. Also, this is a divisional matchup where the underdog has covered 8 of the last 10 games. Six of those covers were outright wins for the underdog. Kyle Shanahan always has his team ready. I’ll grab the points with the 49ers at home.