Buccaneers vs 49ers Prediction 10/12/25 NFL Picks Today

The San Francisco 49ers and Tampa Bay Buccaneers meet Sunday in NFL action at Raymond James Stadium. Here’s a Buccaneers vs 49ers Prediction. This article will include a Buccaneers vs 49ers Pick.

San Francisco 49ers Betting Preview

The San Francisco 49ers beat the Rams, lost to the Jaguars, and play the Falcons next. The San Francisco 49ers have lost 8 of their last 13 games. Mac Jones is completing 66.7 percent of his passes for 905 yards, 6 touchdowns, and 1 interception. Ricky Pearsall and Christian McCaffrey have combined for 714 receiving yards and 3 touchdowns, while Kendrick Bourne has 18 receptions.

The San Francisco 49ers ground game is averaging 85.2 yards per contest, and Christian McCaffrey leads the way with 282 yards on 91 carries. Defensively, San Francisco is allowing 19.8 points and 315.6 yards per game. Fred Warner leads the San Francisco 49ers with 38 tackles, Bryce Huff has 2 sacks and Renardo Green has 3 pass deflections.

Tampa Bay Buccaneers Betting Preview

The Tampa Bay Buccaneers lost to the Eagles, beat the Seahawks, and they play the Lions next. The Tampa Bay Buccaneers have won 10 of their last 12 regular season games. Baker Mayfield is completing 65.1 percent of his passes for 1,283 yards, 10 touchdowns, and 1 interception. Bucky Irving and Emeka Egbuka have combined for 638 receiving yards and 7 touchdowns, while Sterling Shepard has 17 receptions.

The Tampa Bay Buccaneers ground game is averaging 110.4 yards per contest, and Bucky Irving leads the way with 237 yards on 71 carries. Defensively, Tampa Bay is allowing 26.4 points and 310.8 yards per game. Tykee Smith leads the Tampa Bay Buccaneers with 39 tackles, Vita Vea has 2 sacks and Jamel Dean has 1 interception.

Why the Tampa Bay Buccaneers will win

• The Buccaneers have won each of their last four games when playing with a rest disadvantage.
• The 49ers have lost 13 of their last 16 interstate games when playing with a rest advantage.
• The 49ers have failed to cover the spread in each of their last nine Sunday games against teams that held a winning record.
• The Buccaneers have covered the spread in nine of their last 11 games as favorites when playing with a rest disadvantage.
• The Buccaneers have won the first quarter in five of their last seven home games against teams that held a winning record.
• The favorites have won the first half in seven of the last eight games between the 49ers and Buccaneers.

Why the San Francisco 49ers will win

• The 49ers have won each of their seven previous games against the Buccaneers following a road win.
• The Buccaneers have lost four of their last five October games as favorites.
• The road team has covered the spread in each of the Buccaneers’ last seven games.
• The Buccaneers have failed to cover the spread in each of their last seven home games in October.
• The 49ers have won the first quarter in four of their last five games against teams that held a winning record.
• The 49ers have won the first half in seven of their last eight games against NFC South opponents.
• The 49ers have scored the first touchdown in nine of their last 10 games against NFC South opponents.

Total Points Facts

• Each of the 49ers’ last six games played as underdogs on the East Coast have gone UNDER the total points line.
• Each of the Buccaneers’ last five games in October have gone OVER the total points line.
• Four of the last five Sunday games at Raymond James Stadium have gone OVER the total points line.

Tampa Bay Buccaneers Player Prop Facts

• Bucky Irving has scored a touchdown in eight of his last nine appearances against NFC opponents.
• Chris Godwin has recorded 59+ receiving yards in each of his last eight October home appearances.
• Bucky Irving has recorded 68+ rushing yards in seven of the Buccaneers’ last eight games as favorites against NFC opponents.
• Baker Mayfield has recorded 325+ passing yards in each of the Buccaneers’ last four October games.
• Mike Evans has scored the first touchdown in three of his last four regular season home appearances against NFC opponents.
• Chris Godwin has recorded 59+ rushing and receiving yards in each of his last eight October home appearances.
• Baker Mayfield has recorded 24+ completions in each of the Buccaneers’ last four October games.
• Heading into Week 6, Emeka Egbuka ranks 1st in the NFL in 20+ yard receiving touchdowns (4) this season.

San Francisco 49ers Player Prop Facts

• Russell Gage has scored the last touchdown in three of his last four regular season appearances with his team as an underdog.
• Brian Robinson has scored at least one touchdown in each of his last seven Sunday regular season appearances with his team as a road underdog.
• Demarcus Robinson has recorded 37+ receiving yards in eight of his last nine road appearances against NFC opponents.
• Brian Robinson has recorded 24+ rushing yards in each of his last 14 Sunday regular season appearances with his team as an underdog.
• Brock Purdy has recorded 244+ passing yards in each of his last six October appearances against NFC opponents.
• Brian Robinson has recorded 35+ rushing and receiving yards in each of his last 16 Sunday appearances with his team as an underdog.
• Brock Purdy has recorded 22+ completions in each of his last four appearances.
• Heading into Week 6, Eddy Pineiro has recorded the most made field goals without a failed attempt this season (11).

Matchup/League Facts

• Buccaneers – four different players have recorded 70+ receiving yards in a game this season – equal-most in the NFL, heading into Week 6.
• Buccaneers – four different players have recorded 80+ receiving yards in a game this season – equal-most in the NFL, heading into Week 6.
• 49ers – four different players have recorded 70+ receiving yards in a game this season – equal-most in the NFL, heading into Week 6.
• 49ers – four different players have recorded 80+ receiving yards in a game this season – equal-most in the NFL, heading into Week 6.

Buccaneers vs 49ers Prediction

We’re getting points with the 49ers who have had extra time to prepare for this game and like I said last week it feels like people keep trying to write off this team given the injury situation. The 49ers showed just that last week with a big upset over the Rams. The problem is the Bucs are a team that continues to grow on me, and that top-10 scoring offense should test this 49ers defense.

Mayfield is playing at an MVP level right now, and it feels like the entire team has piked up his confidence. The Buccaneers are a team to watch right now, and I’m not trying to step in front of them. I’ll lay the small number with the home team.