Buffalo Bills vs San Francisco 49ers Prediction 12-1-24 Picks

In this article, we will formulate a Buffalo Bills vs San Francisco 49ers Prediction for this NFL Week 13 game on Sunday, December 1st, at the Highmark Stadium.

Bills Keep Winning

The Bills look like they could win the Super Bowl this season and they keep winning games. The Bills last game came against the Kansas City Chiefs and they were able to secure the 30-21 victory. Josh Allen completed 27 of his 40 passes for 262 yards, one touchdown, and one interception. Allen was the top rusher also finishing with 12 carries for 55 yards and a touchdown. The Bills did have a bye week and they hope that will help them get  healthy. Keon Coleman is dealing with a wrist injury and he’s questionable for this game. Dalton Kincaid is dealing with a knee injury and is also questionable for this game. The Bills are averaging 29.1 points while their defense is giving up 19.5 points per game. The offense is ranked 3rd in the league while the defense is ranked 7th. 

Why the Bills Will Beat the 49ers

• The Bills have won each of their last 12 games at Highmark Stadium against opponents on a losing streak.
• The 49ers have lost four of their last five games against AFC opponents on a winning streak.
• The 49ers have failed to cover the spread in eight of their last nine games against teams that held a winning record.
• The Bills have covered the spread in six of their last seven games against NFC West opponents.
• The 49ers have lost the first half in four of their last five games as underdogs.

49ers is Dealing With Injuries

The 49ers are dealing with some major injuries right now and they could wreak some havoc on this game. Brock Purdy had to miss the last game with a shoulder injury and he’s been doing some light throwing early in the week as he tries to get back. In the last game against the Green Bay Packers, the 49ers only scored 10 points, while the defense gave up 38 points. Brandon Allen filled in for Purdy and he completed 17 of his 29 passes for 199 yards, one touchdown, and one interception. The offense wasn’t good, but the defense also was a major issue. If Purdy can’t go this week, it will be Allen that is going to get the start here. The 49ers are averaging 23.6 points while their defense is giving up 23.6 points per game. The offense is ranked 13th in the league while the defense is ranked 20th. Nick Bosa is dealing with a hip injury and he’s questionable for this game. 

Buffalo Bills vs San Francisco 49ers prediction

Even if Brock Purdy plays, the Bills are going to put on a show here. Even with Purdy this season, the 49ers haven’t played all that well this season. Josh Allen is having an MVP type season and the Bills are going to have no issue running up the score here. Look for the Bills to score at least 28 points here, and that is going to be the difference here. The 49ers offense isn’t going to be keeping up, and the Bills will cruise. Look for Purdy to throw a couple of interceptions, too. Back the Bills against the spread.