Carolina Panthers vs Buffalo Bills Prediction 10/26/25 NFL Picks Today

The Buffalo Bills and the Carolina Panthers meet in week 8 NFL action from Bank of America Stadium on Sunday. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Buffalo Bills vs. Carolina Panthers prediction.

Buffalo Bills Recap

The Buffalo Bills come into this game looking to rebound from a 24-14 loss at the hands of the Atlanta Falcons last time out to sit at 4-2 this season prior to last week’s bye week. After this game, Buffalo will head home for a game against the Kansas City Chiefs.

Bills Drop Back-To-Back Games

Josh Allen has thrown for 1,397 yards, 11 touchdowns and 4 interceptions on 68.5% passing while also rushing for 254 yards and 3 scores. James Cook has a team-high 537 rushing yards and 5 touchdowns while Dalton Kincaid has a team-high 287 receiving yards and 3 touchdowns this season. Khalil Shakir has 268 receiving yards and 25 receptions along with a pair of touchdowns while Keon Coleman has 237 receiving yards and 4 catches with 2 touchdowns and Josh Palmer has 14 catches for 234 yards this season. On defense, Terrel Bernard leads the Bills with 30 total tackles while the Bills’ defense as a whole has combined for 15 sacks and 2 interceptions so far this season.

Why the Buffalo Bills will win

• The Panthers have lost each of their last 11 games when playing with a rest disadvantage.
• The Bills have won each of their last 11 games as favorites when playing with a rest advantage.
• The Panthers have failed to cover the spread in each of their last nine games following a road win.
• The Bills have covered the spread in each of their last four games following a road loss.

Buffalo Bills Player Prop Facts

• James Cook has scored two or more touchdowns in four of the Bills’ last five road games against teams that held a winning record.
• Josh Allen has scored at least one touchdown in each of the Bills’ last 13 games against teams on a winning streak.
• Josh Allen has recorded 22+ completions in four of the Bills’ last five road games against NFC opponents.
• Keon Coleman has recorded 45+ receiving yards in four of his five previous appearances against NFC opponents.
• Josh Allen has recorded 272+ passing yards in each of the Bills’ last three games following a road loss.
• Josh Allen has recorded 41+ rushing yards in 10 of the Bills’ last 11 road games against NFC opponents.
• James Cook has recorded 99+ rushing and receiving yards in each of his last six appearances following a road loss.
• Heading into Week 8, James Cook is the only player in the NFL to record 100+ rushing yards in three or more consecutive games this season.

Carolina Panthers Recap

The Carolina Panthers come into this game looking to build on their 13-6 win over the New York Jets last time out to sit at 4-3 this season. After this game, Carolina will head on the road for a game against the Green Bay Packers.

Panthers Win Three In A Row

Bryce Young has thrown for 1,288 yards, 11 touchdowns and 5 interceptions on 61.6% passing while Rico Dowdle has a team-high 551 rushing yards and 2 TDs and Chuba Hubbard has 248 rushing yards as well this season. Tetairoa McMillan has a team-high 30 catches for 413 yards and five more Panthers have 100+ receiving yards as well on the year. On defense, Christian Rozeboom has a team-high 50 total tackles while Tre’von Moehrig has 46 total tackles with a team-high 30 solo tackles. As a unit, Carolina’s defense has combined for 11 sacks and 6 interceptions so far this season.

Why the Carolina Panthers will win

• The underdogs have won each of the Panthers’ last five games at Bank of America Stadium.
• The Bills have lost three of their last four games as road favorites.
• The underdogs have covered the spread in each of the Panthers’ last eight games at Bank of America Stadium.
• The Bills have failed to cover the spread in each of their last four games.

Carolina Panthers Player Prop Facts

• Rico Dowdle has scored a touchdown in each of his last four home appearances.
• Andy Dalton has recorded 21+ completions in six of his last seven Week 8 appearances.
• Andy Dalton has recorded 229+ passing yards in each of his last eight Week 8 appearances.
• Chuba Hubbard has recorded 49+ rushing yards in seven of his last eight appearances against AFC opponents.
• Chuba Hubbard has recorded 54+ rushing and receiving yards in each of his last 15 appearances against AFC opponents.
• Chuba Hubbard has recorded 13+ receiving yards in seven of his last eight appearances.
• Heading into Week 8, Rico Dowdle ranks 1st amongst qualified players for Yards Per Carry (5.6) this season.

Total Points Facts

• Nine of the Panthers’ last 10 games at Bank of America Stadium have gone OVER the total points line.
• Each of the Bills’ last four Week 8 games have gone UNDER the total points line.

Buffalo Bills vs. Carolina Panthers Prediction

I’m on the Panthers and the points in this one. I get why Buffalo would be favored, but the problem is that the Panthers have been at their best by a fair margin at home this season and while you could knock some of the competition that Carolina has had, I still think that they deserve a bit more respect than what they’re getting here. Give me the Panthers and the points here.