Chargers vs 49ers
August 20, 2026 10:00 pm EDT
The Line: Chargers +1.5
(Get latest betting odds)
The San Francisco 49ers and Los Angeles Chargers meet Thursday in NFL preseason action at SoFi Stadium. Here’s a Chargers vs 49ers Prediction. This article will include a Chargers vs 49ers Pick.
San Francisco 49ers Betting Preview
The 49ers are coming off a preseason loss to the Titans. The 49ers are 3-3-1 SU in their last 7 preseason games.
In the losing effort, Adrian Martinez threw for 159 yards on 30 attempts while Kurtis Rourke had 101 passing yards. Sincere McCormick led the 49ers with 38 rushing yards while De’Zhaun Stribling and Jordan Watkins combined for 122 receiving yards on 13 catches. Defensively, Nick Martin led the 49ers with 8 tackles, Tatum Bethune had 1 sack, and Sebastian Valdez had 1 tackle for loss.
Los Angeles Chargers Betting Preview
The Chargers blasted the Texans in their preseason opener and now get their first home game. The Chargers have won 4 of their last 6 preseason games.
In the victory, Trey Lance threw for 164 yards and 1 interception while DJ Uiagalelei had 120 passing yards and 1 touchdown. Lance led the Chargers with 27 rushing yards while Amar Johnson and KeAndre Lambert-Smith combined for 126 receiving yards on 6 catches. Defensively, Emany Johnson led the Chargers with 6 tackles, Jahmeer Carter had 1 sack and Kendall Williamson had 1 tackle for loss.
Chargers vs 49ers Prediction
Those who have followed me over the years know my handicapping in preseason is all about the quarterback position. The rest of the positions are toss-ups, and you have no idea who is going to play nd for how long. The one constant thing is decent quarterback play and the guys who can put points on the board.
Both teams are dealing with a lot of injuries, and the Chargers just lost their center, which is a crushing blow. I’m still surprised the Chargers are underdogs in this spot, as Lance and Uiagalelei looked good in the preseason opener and are playmakers who can expose lesser defenders. I like their upside and playmaking ability over a combination of Rourke and Martinez. Give me the 1.5 points with the Chargers on late Thursday night.
