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Giants vs 49ers Prediction 11/2/25 NFL Picks Today

San Francisco 49ers (5-3) vs. NY Giants (2-6)
November 2, 2025 1:00 pm EDT
The Line: NY Giants +2.5; Over/Under: 48.5
(Get latest betting odds)

The San Francisco 49ers and New York Giants meet Sunday in NFL action at MetLife Stadium. Here’s a Giants vs 49ers Prediction. This article will include a Giants vs 49ers Pick.

San Francisco 49ers Betting Preview

The San Francisco 49ers beat the Falcons, lost to the Texans, and play the Rams next. The San Francisco 49ers have split their last 6 games. Mac Jones is completing 65.9 percent of his passes for 1,597 yards, 8 touchdowns, and 5 interceptions. Kendrick Bourne and Christian McCaffrey have combined for 988 receiving yards and 3 touchdowns, while Ricky Pearsall has 20 receptions.

The San Francisco 49ers ground game is averaging 89.4 yards per contest, and Christian McCaffrey leads the way with 490 yards and 3 touchdowns. Defensively, San Francisco is allowing 20.5 points and 337.1 yards per game. Dee Winters leads the San Francisco 49ers with 54 tackles, Bryce Huff has 4 sacks and Deommodore Lenoir has 1 interception.

New York Giants Betting Preview

The New York Giants lost to the Broncos and Eagles, and they play the Bears next. The New York Giants have lost 7 of their last 9 games. Jaxson Dart is completing 59.9 percent of his passes for 984 yards, 8 touchdowns, and 3 interceptions. Wan’Dale Robinson and Malik Nabers have combined for 765 receiving yards and 4 touchdowns, while Theo Johnson has 23 receptions.

The New York Giants ground game is averaging 118 yards per contest, and Cam Skattebo leads the way with 410 yards and 5 touchdowns. Defensively, New York is allowing 26.9 points and 382.4 yards per game. Bobby Okereke leads the New York Giants with 68 tackles, Brian Burns has 10 sacks and Dru Phillips has 2 interceptions.

Why the New York Giants will win

  • The home team has won 10 of the Giants’ last 11 games.
  • The 49ers have lost three of their last four games against teams that held a losing record.
  • The 49ers have failed to cover the spread in each of their last five Week 9 games against NFC opponents.
  • The home team has covered the spread in four of the Giants’ last five games.
  • The Giants have won the first quarter in four of their last five games as underdogs.
  • The 49ers have lost the first half in seven of their last eight Sunday road games.
  • The Giants have scored the first touchdown in each of their last four home games.

Why the San Francisco 49ers will win

  • The Giants have lost each of their last eight home games against NFC West opponents.
  • The 49ers have won each of their last six games against starting rookie QBs.
  • The 49ers have covered the spread in each of their last eight games as favorites against NFC East opponents.
  • The Giants have failed to cover the spread in 12 of their last 13 home games against NFC West opponents.
  • The 49ers have won the first quarter in each of their last six November games as favorites.
  • The Giants have lost the first half in 15 of their last 16 games against NFC West opponents.
  • The 49ers have scored the first touchdown in each of their last six games as road favorites.

Total Points Facts

  • Seven of the 49ers’ last eight games as favorites following a loss have gone OVER the total points line.
  • Five of the Giants’ last six November games as home underdogs have gone UNDER the total points line.
  • Four of the last five Sunday games at MetLife Stadium have gone UNDER the total points line.

New York Giants Player Prop Facts

  • Jaxson Dart has scored a touchdown in each of the Giants’ last four games against teams that held a winning record.
  • Jaxson Dart has recorded 195+ passing yards in three of the Giants’ last four games.
  • Tyrone Tracy has recorded 23+ rushing yards in each of his last 10 appearances in Sunday games played on the East Coast.
  • Darius Slayton has recorded 40+ receiving yards in five of the Giants’ last six November home games against NFC opponents.
  • Tyrone Tracy has recorded 35+ rushing and receiving yards in each of his last 13 Sunday appearances.
  • Heading into Week 9, Brian Burns ranks T1st in the NFL in sacks (10.0) this season.

San Francisco 49ers Player Prop Facts

  • Christian McCaffrey has scored two or more touchdowns in three of his last four Week 9 appearances.
  • George Kittle has scored at least one touchdown in each of his last four appearances with the 49ers as road favorites against NFC opponents.
  • Brock Purdy has recorded 255+ passing yards in each of the 49ers’ last seven games as favorites following a loss.
  • Brian Robinson has recorded 13+ rushing yards in each of his 10 previous November appearances.
  • Brian Robinson has scored the first touchdown in three of his last four November road appearances.
  • Christian McCaffrey has recorded 52+ receiving yards in each of the 49ers’ last six games against NFC opponents.
  • Brian Robinson has recorded 24+ rushing and receiving yards in each of his 10 previous November appearances.
  • Brock Purdy has recorded 22+ completions in each of his last six Sunday regular season appearances with the 49ers as road favorites.
  • Heading into Week 9, Christian McCaffrey is the only players averaging over 20.0 rushing yards and 60.0 receiving yards per game this season.

Matchup/League Facts

  • Giants – seven different players have recorded 50+ receiving yards in a game this season – equal-most in the NFL, heading into Week 9.
  • Giants – six different players have recorded 60+ receiving yards in a game this season – equal-most in the NFL, heading into Week 9.
  • Heading into Week 9, the 49ers rank T1st in the NFL in fumbles recovered (6) this season.
  • Heading into Week 9, the 49ers have recorded the equal-most wins by a margin of 10 points or less this season (5).

Giants vs 49ers Prediction

I considered the Giants and the points because even without Skattebo, there’s some swagger to this team with Dart at quarterback. The problem is the 49ers defense is comfortably the best unit in this game and is why they’re favored on the road. The Giants have had issues getting off the field defensively and are 29th in total defense and 26th in scoring defense. This is a spot where the 49ers could bully the Giants in the trenches and leave the big apple with an ugly win. I’m not getting enough points with the home team. Give me the 49ers on the road.

Randy Chambers's Free Pick: San Francisco 49ers -2.5

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Randy Chambers

Randy has covered sports betting since 2014 and writes about everything from NFL to WNBA. Follow Randy Chambers on Twitter.

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