Jaguars vs 49ers Prediction 9/28/25 NFL Picks Today

In this article, we will formulate a Jaguars vs 49ers Prediction for this NFL Week 4 game on Sunday, September 28^th at the Levi’s Stadium. Let’s take a look at the prediction for this NFL matchup.

San Francisco 49ers Preview

The San Francisco 49ers have a 3-0 record this season and are sitting in 1st place of the NFC West. They are 2-1 ATS, 1-2 in Over/Under and have a 1-0 home record and 2-0 away record. The 49ers are coming off a 16-15 home win to Arizona Cardinals and are the Los Angeles Rams and Tampa Bay Buccaneers next.

Offensively, the 49ers average 19.7 points per game, which ranks 23rd in the NFL. Defensively, they allow 16.3 points per game, which is 3rd. San Francisco averages 361.0 total yards per game, with 89.7 rushing yards and 271.3 passing yards per game. They allow 265.7 total yards per game, with 89.7 rushing and 271.3 passing yards per game.

Mac Jones leads the 49ers with 563 passing yards and 66.3% completed passes. Christian McCaffrey leads the team in rushing yards, with 176, while Christian McCaffrey has a team-high 25 caught passes for 213 receiving yards, and has one touchdown. Defensively, Fred Warner has a team-high 30 total tackles, 16 of them solo. Nick Bosa leads the 49ers in sacks, with two.

Jacksonville Jaguars Preview

The Jacksonville Jaguars have a 2-1 record this season and are sitting on the 2nd place of the AFC South. They are 2-1 ATS, 1-2 in Over/Under and have a 0-1 away record and 2-0 home record. The Jaguars are coming off a 17-10 home win against the Houston Texans and are playing the Kansas City Chiefs and Seattle Seahawks next.

Offensively, the Jaguars average 23.3 points per game, which ranks 14th in the NFL. Defensively, they allow 17.0 points per game, which is 5th. Jacksonville averages 356.3 total yards per game, with 141.7 rushing yards and 223.7 passing yards per game. They allow 292.0 total yards per game, with 82.7 rushing and 209.3 passing yards per game.

Trevor Lawrence leads the Jaguars with 671 passing yards and 55.8% completed passes. Travis Etienne leads the team in rushing yards, with 270, while Brian Thomas has a team-high 13 caught passes for 137 receiving yards, and has one touchdown. Defensively, Foyesade Oluokun has a team-high 23 total tackles, 13 of them solo. Travon Walker leads the Jaguars in sacks, with two, while Andrew Wingard has one interception.

Jacksonville Jaguars @ San Francisco 49ers Betting Trends: Week 4

Why the San Francisco 49ers will win

• The Jaguars have lost each of their last eight road games against NFC West opponents.
• The home team has won each of the Jaguars’ last six games.
• The Jaguars have failed to cover the spread in each of their last seven September games as underdogs against NFC opponents.
• The home team has covered the spread in five of the Jaguars’ last six games.
• The 49ers have won the first quarter in each of their last six games against the Jaguars.
• The home team has won the first half in seven of the Jaguars’ last eight games.
• The 49ers have scored the first touchdown in each of their last seven Sunday games as favorites.

Why the Jacksonville Jaguars will win

• The 49ers have lost four of their last five games as home favorites following a win.
• The 49ers have failed to cover the spread in each of their last 10 home games following a win.
• The Jaguars have covered the spread in four of their last five games.
• The Jaguars have won the first quarter in each of their last four Week 4 games as underdogs.
• The Jaguars have won the first half in four of their last five games.
• The Jaguars have scored the first touchdown in 10 of their last 11 Week 4 games.

Total Points Facts

• Each of the Jaguars’ last seven games following a win have gone OVER the total points line.
• Seven of the 49ers’ last eight games following a win have gone UNDER the total points line.

San Francisco 49ers Player Prop Facts

• Brian Robinson has scored at least one touchdown in four of his last five appearances against AFC opponents.
• Brian Robinson has recorded 22+ rushing yards in 20 of his 22 previous Sunday home appearances.
• Brian Robinson has recorded 37+ rushing and receiving yards in eight of his last nine appearances against AFC opponents.
• Kendrick Bourne has recorded 30+ receiving yards in each of his last 10 appearances with the 49ers as favorites.
• Heading into Week 4, Fred Warner ranks T2nd in the league for fumbles recovered (1) this season.

Jacksonville Jaguars Player Prop Facts

• Tim Patrick has scored a touchdown in three of his last four appearances with his team as a road underdog against NFC opponents.
• Travis Etienne has recorded 56+ rushing yards in each of the Jaguars’ last three games.
• Trevor Lawrence has recorded 234+ passing yards in each of his last six appearances following a win.
• Travis Etienne has recorded 77+ rushing and receiving yards in nine of his last 12 appearances following a win.
• Travis Etienne has recorded 15+ receiving yards in each of the Jaguars’ last six games as underdogs.
• Trevor Lawrence has recorded 21+ completions in each of his last six appearances following a win.
• Heading into Week 4, Jourdan Lewis ranks T1st in the NFL in interceptions (2) this season.

Matchup/League Facts

• 49ers – three different players have recorded 70+ receiving yards in a game this season – equal-most in the NFL, heading into Week 4.
• 49ers – three different players have recorded 80+ receiving yards in a game this season – equal-most in the NFL, heading into Week 4.
• Jaguars – one different players have recorded 100+ rushing yards in a game this season – equal-most in the NFL, heading into Week 4.
• Jaguars – six different players have recorded one interception or more in a game this season – most in the NFL, heading into Week 4.

Jaguars vs 49ers Prediction

In their previous meeting in 2023, the 49ers won 34-3 on the road, and have won all of their five meetings against the Jaguars, including both meetings in San Fran. They are also a perfect 5-0 ATS and their last two meetings have gone under the total.

In this Jaguars vs 49ers Prediction, the 49ers are coming as -3-point home favorites, with the total set at 47 points. the 49ers have three straight wins after losing their season opener, while the Jaguars have lost both of their road games this season. The 49ers have the third-best defense in the NFL, and have never lost by the Jaguars. I don’t expect that to change soon, so take the San Francisco 49ers and lay the -3 points at home.