San Francisco 49ers (0-1) vs. Las Vegas Raiders (0-0-1)
August 16, 2025 4:00 pm EDT
The Line: Las Vegas Raiders -4.5; Over/Under: 40.5
(Get latest betting odds)
The San Francisco 49ers and the Las Vegas Raiders meet in week 2 NFL Preseason action from Allegiant Stadium on Saturday. We will look at this from a betting perspective and determine the best bets for this game. Here’s a San Francisco 49ers vs. Las Vegas Raiders prediction.
San Francisco 49ers Recap
The San Francisco 49ers come into this one looking to bounce back after starting the preseason on the wrong foot with a 30-9 loss at the hands of the Denver Broncos in week 1. After this game, the 49ers will take on the Los Angeles Chargers in their preseason Finale.
49ers On Wrong Side Of One Of Week 1’s Most Lopsided Results
Mac Jones threw for 74 yards on 4 of 7 passing with an interception while Carter Bradley threw for 32 yards and an INT on 6 of 14 passing and Tanner Mordecai also threw for 21 yards and an INT on 3 of 6 passing. Corey Kiner rushed for 45 yards on 10 carries while Patrick Taylor Jr. had the Niners’ lone TD on the ground. Jordan Watkins led the Niners’ receiving group with 3 grabs for 56 yards while Jake Tonges has 36 receiving yards as well on the year. On defense, Derrick Canteen and Chase Lucas each had a team-high 8 total tackles while Kalia Davis had a sack as well in the losing effort.
Las Vegas Raiders Recap
The Las Vegas Raiders come into this game looking to get in the win column after a 23-23 tie to start their preseason with their matchup against the Seattle Seahawks. After this game, the Raiders will head on the road for their preseason finale against the Arizona Cardinals.
Raiders Look Solid In Preseason Opener
Aidan O’Connell threw for 205 yards, a TD and 2 INTs on 18 of 30 passing while Cam Miller threw for 76 yards and a TD on 6 of 7 passing. Geno Smith also had 15 passing yards on 1 of 3 passing. Chris Collier had 9 carries for 42 rushing yards and Dylan Laube added 34 rushing yards as well. Shedrick Jackson led the Raiders in receiving with 4 grabs for 76 yards and a touchdown in the tie while Alex Bachman, Phillip Dorsett and Carter Runyon also has 30+ receiving yards. On defense, Hudson Clark, Cody Lindenberg, Michael Barrett and Matt Jones all had a team-high 4 total tackles. Treven Ma’ae added a sack and Isaiah Pola-Mao added an interception as well in the tie.
San Francisco 49ers vs. Las Vegas Raiders Prediction
I’m on the Raiders here. I just feel that the Raiders had much more upside in their week 1 showing and I’m just not all that high on the 49ers depth, especially when you consider who their backups are, especially at the quarterback position as Mac Jones just isn’t a QB I want to have my money on. The Raiders looked really good even in the tie against the Seahawks on the road and I look for a similar showing here at home. Give me the Raiders.
