Giants vs Chargers Prediction 9/28/25 NFL Picks Today

The Los Angeles Chargers and the New York Giants meet Sunday in NFL action from MetLife Stadium. Here’s a Giants vs Chargers prediction. We will look at this from a betting perspective and determine the best Giants vs Chargers pick.

Los Angeles Chargers Betting Preview

The Chargers got off to a good start this year, posting victories against rivals in their first two games. The opener was a matchup versus the Kansas City Chiefs, and Los Angeles managed to score in every quarter along the way to a 27-21 win. Los Angeles managed 394 total yards in the victory, with 304 of those coming through the air. In game two versus the Oakland Raiders, Los Angeles was able to keep it going. The Chargers jumped out to a 17-6 halftime lead and eventually won 20-9. This time LA mustered 317 total yards while holding Las Vegas to just 218 yards (150 passing) and 3.4 yards per play on the other side.

In last weekend’s matchup versus the Denver Broncos, the Chargers played a close one. Los Angeles was down 17-13 going into the final quarter, then closed on a 10-3 run to power out the win 23-20 in the end. QB Justin Herbert was 28-of-47 for 300 yards, one TD and one pick while Omarion Hampton led the rush on 19 carries for 70 yards and a score. Quentin Johnston logged six catches for 89 yards to top the receivers and Keenan Allen added seven catches for 65 yards and a touchdown.

New York Giants Betting Preview

Over on the Giants’ side, their year began with a matchup versus the Washington Commanders. New York could only find a couple of field goals in that one, limping to a 21-6 loss in the end. The Giants offense accounted for just 231 total yards (74 rushing) and 3.7 yards per play in the defeat. In game two versus the rival Dallas Cowboys, New York’s offense got a shot in the arm but still fell short. The result was a tight overtime loss 40-37. This time the Giants posted 506 yards (422 passing) and 7.8 yards per play but also committed 14 of the game’s 26 penalties, resulting in a loss of 160 yards for New York.

On Sunday versus the Chiefs, the Giants were within a field goal at halftime but eventually took a 22-9 loss, giving up points in every quarter along the way. QB Russell Wilson finished with 160 yards and two picks on 18-of-32 passing, and Cameron Skattebo had 10 carries for 60 yards and a touchdown. Skattebo also led the receivers with six grabs for 61 yards and Darius Slayton caught four passes for 30 yards as well.

Los Angeles Chargers @ New York Giants Betting Trends: Week 4

Why the New York Giants will win

• The Chargers have lost three of their last four September games as favorites against NFC opponents.
• The home team has won five of the Giants’ last six games.
• The Giants have covered the spread in five of their last six Week 4 games.
• The Chargers have failed to cover the spread in four of their last five September games as favorites against NFC opponents.
• The Chargers have lost the first half in three of their last four games against NFC East opponents.
• The Chargers have lost the first quarter in each of their last two Week 4 games as favorites against NFC opponents.
• The Giants have scored the first touchdown in each of their last five home games against AFC West opponents.

Why the Los Angeles Chargers will win

• The Giants have lost 14 of their last 15 games.
• The Chargers have won each of their last six road games against NFC opponents on a losing streak.
• The Chargers have covered the spread in each of their last six games against teams that held a losing record.
• The Giants have failed to cover the spread in each of their last five games against teams that held a winning record.
• The Chargers have won the first half in each of their last nine Sunday games as favorites.
• The Chargers have won the first quarter in each of their last six games in September.
• The Chargers have scored the first touchdown in each of their last four Week 4 games.

Total Points Facts

• Each of the Chargers’ last seven Sunday games played on the East Coast have gone UNDER the total points line.
• Each of the Giants’ last six September games as home underdogs have gone UNDER the total points line.

New York Giants Player Prop Facts

• Tyrone Tracy has scored a touchdown in three of the Giants’ last four games as underdogs following a home loss.
• Russell Wilson has recorded 298+ passing yards in four of his five previous September appearances with his team as an underdog against AFC opponents.
• Darius Slayton has recorded 27+ receiving yards in eight of the Giants’ last nine home games as moderate underdogs (+3.5 to +7.0 points).
• Tyrone Tracy has recorded 35+ rushing and receiving yards in each of the Giants’ last 13 games.
• Tyrone Tracy has recorded 23+ rushing yards in each of the Giants’ last 10 games played on the East Coast.
• Jameis Winston has recorded 23+ completions in eight of his last 10 appearances as a starter.
• Heading into Week 4, Malik Nabers ranks T1st in the NFL in 20+ yard receiving touchdowns (2) this season.

Los Angeles Chargers Player Prop Facts

• Keenan Allen has scored the first touchdown in three of his last four September road appearances.
• Keenan Allen has scored a touchdown in each of the Chargers’ last three games.
• Justin Herbert has recorded 281+ passing yards in five of the Chargers’ last six regular season games.
• Keenan Allen has recorded 58+ receiving yards in each of his last seven appearances with the Chargers as favorites.
• Najee Harris has recorded 42+ rushing and receiving yards in each of his last 10 appearances on the East Coast.
• Najee Harris has recorded 28+ rushing yards in 22 of his last 23 appearances with his team as a favorite.
• Justin Herbert has recorded 22+ completions in each of the Chargers’ last five games against NFC East opponents.
• Heading into Week 4, Justin Herbert ranks 1st in the NFL in passing yards (860) this season.

Matchup/League Facts

• Giants – four different players have recorded 60+ receiving yards in a game this season – equal-most in the NFL, heading into Week 4.
• Giants – two different players have recorded 100+ receiving yards in a game this season – equal-most in the NFL, heading into Week 4.
• Chargers – five different players have recorded 50+ receiving yards in a game this season – equal-most in the NFL, heading into Week 4.
• Heading into Week 4, the Chargers rank 1st in the NFL in red zone percentage against (25.0%) this season.

Giants vs Chargers Prediction

I’m going with the Chargers, but I’m probably not touching this one. Los Angeles wasn’t spectacular in their win over Denver last weekend, but they get credit for the late surge. The Chargers ended up with 8-of-17 on third-down tries and a couple of turnovers on offense, gathering 376 total yards (270 passing) and 29 first downs along the way. Los Angeles’ defense was pretty good despite not generating a turnover, allowing 265 yards (147 passing), nine first downs and 2-of-13 on third-down conversions. Denver’s 10 penalties for 90 yards were helpful to the cause as well. LA hasn’t given up more than 21 points in any game yet this year, but they also haven’t scored more than 27 points in any game this year.

As for the Giants, they didn’t look too bad in the first half against Kansas City but eventually posted a couple of interceptions and a miserable 1-of-10 effort on third-down tries. New York has scored more than nine points exactly once in three games (37 versus the Cowboys) and they’ve given up at least 21 points in each outing. I can’t trust them to do anything right now.