Rams vs 49ers Prediction 10/2/25 NFL Picks Today

David Racey

San Francisco 49ers (3-1) vs. LA Rams (3-1)
October 2, 2025 8:15 pm EDT
The Line: LA Rams -6.5; Over/Under: 47
(Get latest betting odds)

In this article we will formulate a Rams vs 49ers prediction for this NFL game on Thursday, October 2nd at SoFi Stadium in Inglewood, California. Let’s take a look at the prediction for this week 5 matchup.

Los Angeles Rams Betting Preview

The Los Angeles Rams are 3-1 this season after they defeated Indianapolis by a score of 27-20 last week. Los Angeles led 13-10 at halftime, but they trailed 20-13 in the fourth quarter, before scoring 14 points in the final 3:20 to steal the win. The Rams out gained Indianapolis by a total of 462-333, went 4-12 on third downs, and won the turnover battle by a margin of 3-1 in the game. Matthew Stafford went 29-41 with 375 yards and three touchdowns, while Kyren Williams rushed 13 times for 77 yards. Puka Nacua led the LA receivers with 13 receptions for 170 yards and one score in the win. The Rams defense recorded two sacks and four tackles for loss in the game.

In their first three games, Los Angeles defeated Houston and Tennessee to start the season, but they lost to Philadelphia in their third game. The Rams are averaging 25.0 points per game with 267.5 passing yards and 120.8 rushing yards per game, while they are allowing 20.3 points against per game this season. Matthew Stafford has completed 67.6% of his passes for 1,114 yards, eight touchdowns, and two interceptions, while Puka Nacua has 42 receptions for 503 yards and one touchdown. Kyren Williams has led the LA rushing attack with 303 yards and one score on 68 carries this season.

San Francisco 49ers Betting Preview

The San Francisco 49ers are 3-1 this year after they lost to Jacksonville by a score of 26-21 last week. San Francisco trailed 17-6 at halftime and they cut the deficit to 17-14 in the third, but allowed the next nine points for the loss. The 49ers out gained Jacksonville by a total of 389-325, went 8-13 on third downs, and lost the turnover battle by a margin of 4-0 in the game. Brock Purdy went 22-38 for 309 yards, two touchdowns, and two interceptions, while Christian McCaffrey rushed 17 times for 49 yards. McCaffrey also led the receivers with six catches for 92 yards and one score in the loss. The SF defense recorded zero sacks and six tackles for loss in the game.

In their first three games, San Francisco defeated Seattle by a score of 17-13, New Orleans by a score of 26-21, and Arizona by a score of 16-15. The 49ers are averaging 20.0 points per game with 280.0 passing yards and 88.0 rushing yards per game, while they are allowing 18.8 points against per game this season. Brock Purdy has completed 65.8% of his passes for 586 yards, four touchdowns, and four interceptions, while Ricky Pearsall has caught 20 passes for 327 yards. Christian McCaffrey has led the ground game with 69 carries for 225 yards this year.

Why the 49ers will beat the Rams

The 49ers have won six of their last seven games as underdogs against the Rams.
The Rams have lost four of their last five games as home favorites following a home win.
The 49ers have covered the spread in each of their last seven games as underdogs against the Rams.
The Rams have failed to cover the spread in each of their last five Week 5 home games.
The 49ers have won the first half in each of their last six Thursday road games.
The 49ers have scored the first touchdown in each of their last four Thursday road games.
The 49ers have won the first quarter in each of their last five Thursday games against teams that held a winning record.

Total Points Facts

Each of the Rams’ last six games played as favorites on the West Coast have gone UNDER the total points line.
Each of the 49ers’ last four road games following a home loss have gone OVER the total points line.
Six of the last seven games between teams from the same division have gone UNDER the total points line.

Los Angeles Rams Player Prop Facts

Kyren Williams has scored the first touchdown in five of his last six home appearances.
Matthew Stafford has recorded 22+ completions in 12 of his last 13 Thursday home appearances.
Puka Nacua has recorded 98+ receiving yards in each of his last eight regular season home appearances.
Matthew Stafford has recorded 236+ passing yards in each of his last six Thursday home appearances.
Kyren Williams has recorded 72+ rushing yards in eight of his last nine home appearances against NFC opponents.
Kyren Williams has scored at least one touchdown in each of his last nine home appearances against NFC opponents.
Puka Nacua has recorded 108+ rushing and receiving yards in each of his last six appearances in California.
Heading into Week 5, Puka Nacua ranks 1st in the NFL in receiving yards (503) this season.

San Francisco 49ers Player Prop Facts

Brian Robinson has recorded 20+ rushing yards in each of his 22 previous regular season appearances with his team as an underdog.
Christian McCaffrey has scored at least one touchdown in each of his last six October appearances.
Kendrick Bourne has recorded 32+ receiving yards in each of his last nine appearances against NFC opponents.
Russell Gage has scored the last touchdown in three of his last four regular season appearances with his team as an underdog.
Brian Robinson has recorded 35+ rushing and receiving yards in each of his last 22 appearances with his team as an underdog.
Heading into Week 5, Christian McCaffrey is one of only two players averaging over 20.0 rushing yards and 60.0 receiving yards per game this season.

Matchup/League Facts

Rams – two different players have recorded 100+ receiving yards in a game this season – equal-most in the NFL, heading into Week 5.
Heading into Week 5, the Rams rank T1st in the NFL in Q2 win percentage (75.0) this season.
Heading into Week 5, the 49ers rank T1st in the NFL in Q1 win percentage (75.0) this season.
Heading into Week 5, the 49ers rank T1st in the NFL in Q4 win percentage (75.0) this season.