Saints vs 49ers Prediction 9/14/25 NFL Picks Today

The San Francisco 49ers and New Orleans Saints meet Sunday in NFL action at Caesars Superdome. Here’s a Saints vs 49ers Prediction. This article will include a Saints vs 49ers Pick.

San Francisco 49ers Betting Preview

The San Francisco 49ers beat the Seahawks, and play the Cardinals and Jaguars next. The San Francisco 49ers have lost 7 of their last 9 games. Brock Purdy is completing 74.3 percent of his passes for 277 yards, 2 touchdowns, and 2 interceptions. Ricky Pearsall and Christian McCaffrey have combined for 181 receiving yards on 13 catches, while Kyle Juszczyk has 2 receptions.

The San Francisco 49ers ground game is averaging 119 yards per contest, and Christian McCaffrey leads the way with 69 yards on 22 carries. Defensively, San Francisco is allowing 13 points and 230 yards per game. Fred Warner leads the San Francisco 49ers with 8 tackles, Nick Bosa has 1 sack and Upton Stout has 1 pass deflection.

New Orleans Saints Betting Preview

The New Orleans Saints lost to the Cardinals, and they play the Seahawks and Bills next. The New Orleans Saints have lost 5 straight games. Spencer Rattler is completing 58.7 percent of his passes for 214 yards, 0 touchdowns, and 0 interceptions. Juwan Johnson and Chris Olave have combined for 130 receiving yards on 15 catches, while Rashid Shaheed has 6 receptions.

The New Orleans Saints ground game is averaging 107 yards per contest, and Alvin Kamara leads the way with 45 yards and 1 touchdown. Defensively, New Orleans is allowing 20 points and 276 yards per game. Pete Werner leads the New Orleans Saints with 9 tackles, Cameron Jordan has 1.5 sacks and Carl Granderson has 2 pass deflections.

San Francisco 49ers @ New Orleans Saints Betting Trends: Week 2

Why the New Orleans Saints will win

• The 49ers have lost each of their last four games as favorites following a road win.
• Brandin Cooks’ team has won each of its last four games with him playing against Jason Pinnock.
• The 49ers have failed to cover the spread in each of their last 10 games following a win.
• The Saints have covered the spread in five of their last six Sunday games against teams that held a winning record.
• The Saints have scored the first touchdown in five of their last six games following a loss.
• The 49ers have lost the first quarter in three of their last four games as road favorites following a road win.
• The home team has won the first half in eight of the 49ers’ last nine games.

Why the San Francisco 49ers will win

• The 49ers have won eight of their last nine road games following a Division win.
• The Saints have lost each of their last five games.
• The 49ers have covered the spread in seven of their last eight road games following a Division win.
• The Saints have failed to cover the spread in seven of their last eight Week 2 games.
• The 49ers have won the first quarter in each of their last nine games as favorites against NFC opponents.
• The 49ers have won the first half in each of their last four games against NFC South opponents.
• The 49ers have scored the first touchdown in nine of their last 10 games as favorites against NFC South opponents.

Total Points Facts

• Each of the 49ers’ last six games following a win have gone UNDER the total points line.
• Seven of the Saints’ last eight Week 2 games against NFC opponents have gone UNDER the total points line.
• Four of the last five Sunday games at Caesars Superdome have gone UNDER the total points line.

New Orleans Saints Player Prop Facts

• Alvin Kamara has scored the first touchdown in four of his last five September appearances with the Saints as underdogs.
• Alvin Kamara has scored at least one touchdown in each of his last five September appearances with the Saints as underdogs.
• Taysom Hill has recorded 21+ receiving yards in each of his last five appearances.
• Taysom Hill has recorded 39+ rushing and receiving yards in each of his last six Sunday appearances with the Saints as home underdogs.
• Alvin Kamara has recorded 69+ rushing yards in six of his last seven September appearances with the Saints as underdogs.
• Heading into Week 2, Spencer Rattler has recorded the equal-most pass attempts in a single game this season (46 vs Cardinals, Week 1).

San Francisco 49ers Player Prop Facts

• Christian McCaffrey has scored at least one touchdown in 21 of his last 24 appearances following a win.
• Demarcus Robinson has recorded 19+ receiving yards in eight of his last nine Sunday road appearances.
• Christian McCaffrey has recorded 103+ rushing and receiving yards in each of his last 10 appearances following a win.
• Brock Purdy has recorded 255+ passing yards in each of his last five road appearances against NFC opponents.
• Christian McCaffrey has recorded 78+ rushing yards in each of his last seven appearances following a road win.
• Brock Purdy has recorded 22+ completions in each of the 49ers’ last six Sunday regular season games as road favorites.
• Heading into Week 2, Christian McCaffrey ranks 1st in the NFL in rushing attempts (22) this season.

Matchup/League Facts

• Heading into Week 2, the Saints rank T1st in the NFL in 4th down percentage against (0.0%) this season.
• Heading into Week 2, the Saints rank T1st in the NFL in Q4 win percentage (100.0) this season.
• 49ers – two different players have recorded 70+ receiving yards in a game this season – equal-most in the NFL, heading into Week 2.
• 49ers – one different players have recorded 100+ receiving yards in a game this season – equal-most in the NFL, heading into Week 2.

Saints vs 49ers Prediction

The 49ers are the better team, as many expected the Saints to be the worst team in the league. However, the 49ers are starting the season with back-to-back road games, and a win over the Seahawks doesn’t make us forget the questions with this team and how last year played out. McCaffrey is still gimpy and George Kittle is now on the IR.

The 49ers are 6-10 ATS in their last 16 games when favorites of 3 or more points, and 7 of those failed covers were outright losses. The Saints put up a fight against the Cardinals opening week, and they have a major edge with not having to travel. The 49ers have depth issues on defense and injury concerns on offense to just throw these numbers out on the road. I’ll grab the points with the Saints at home.